Activated protein C improves survival in severe sepsis patients with elevated troponin

Intensive Care Medicine

Volumn 33, Issue 12, 2007, Pages 2122-2128

  John, Jijo ^a   Awab, Ahmed ^a   Norman, Derek ^b   Dernaika, Tarek ^a   Kinasewitz, Gary T ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Activated protein C; Cardiac injury; Drotrecogin alfa activated; Sepsis; Sepsis survival; Troponin

Indexed keywords

DROTRECOGIN; TROPONIN;

ADULT; AGED; APACHE; ARTICLE; COMORBIDITY; CONSENSUS; CONTROLLED STUDY; DISEASE MARKER; FEMALE; FISHER EXACT TEST; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PATIENT IDENTIFICATION; SEPSIS; SURVIVAL; TREATMENT OUTCOME;

AGED; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PROTEIN C; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; SEPSIS; SURVIVAL ANALYSIS; TREATMENT OUTCOME; TROPONIN;

EID: 36448941829     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-007-0816-7     Document Type: Article

References (30)

1. Ammann P, Pfisterer M, Fehr T (2004) Raised cardiac troponins. BMJ 328:1028-1029
2. Gunnewiek JM, Van der Hoeven JG (2004) Cardiac troponin elevations among critically ill patients. Curr Opin Crit Care 10:342-346
3. Ver Elst KM, Spapen HD, Nguyen DN, Garbar C, Huyghens LP, Gorus FK (2000) Cardiac troponin I and T are biological markers of left ventricular dysfunction in septic shock. Clin Chem 46:650-657
4. Ammann P, Fehr T, Minder EI, Gunter C, Bertel O (2001) Elevation of troponin I in sepsis and septic shock. Intensive Care Med 27:965-969
5. Ammann P, Maggiorini M, Bertel O et al. (2003) Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes. J Am Coll Cardiol 41:2004-2009
6. Maeder M, Fehr T, Rickli H, Ammann P (2006) Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac troponins and natriuretic peptides. Chest 129:1349-1366
7. Piper HM, Schwartz P, Spahr R (1984) Early enzyme release from myocardial cells is not due to irreversible cell damage. J Mol Cell Cardiol 16:385-388
8. Wu AHB (2001) Increased troponin in patients with sepsis and septic shock: myocardial necrosis or reversible myocardial depression. Intensive Care Med 27:959-961
9. van Bockel E, Tulleken JE, Muller Kobold AC et al. (2003) Cardiac troponin I release and cytokine response during experimental human endotoxaemia. Intensive Care Med 29:1598-1600
10. Beranek JT (2002) Cardiomyocyte apoptosis contributes to the pathology of the septic shock heart. Intensive Care Med 28:218
11. Fernandes C Jr, Akamine N, Knobel E (1999) Cardiac troponin: a new serum marker of myocardial injury in sepsis. Intensive Care Med 25:1165-1168
12. Spies C, Haude V, Fitzner R et al. (1998) Serum cardiac troponin T as a prognostic marker in early sepsis. Chest 113:1055-1063
13. Metha NJ, Khan IA, Gupta V (2004) Cardiac troponin predicts myocardial dysfunction and adverse outcome in septic shock. Int J Cardiol 95:13-17
14. Yan SB, Helterbrand JD, Hartman DL, Wright TJ, Bernard GR (2001) Low levels of protein C are associated with poor outcome in severe sepsis. Chest 120:915-922
15. Bajzar L, Nesheim ME, Tracy PB (1996) The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood 88:2093-2100
16. Vervloet MG, Thijs LG, Hack CE (1998) Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock. Semin Thromb Hemost 24:33-44
17. Bernard GR, Vincent J-L, Laterre P-F (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 273:1945-1949
18. John J, Awab A, Kinasewitz G, Norman D (2006) Activated protein C improves survival in severe sepsis patients with elevated troponin. Crit Care Med 34:A112
19. Levy MM, Fink MP, Marshall JC et al. (2003) 2001 SCCM/ESICMA/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 31:1250-1256
20. Taylor FB Jr, Toh C-H, Hoots WK, Wada H, Levi M (2001) Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. J Thromb Haemost 86:1327-1330
21. Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II: a severity of disease classification system. Crit Care Med 13:818-829
22. Marshall J, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ (1995) Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23:1638-1652
23. Alpert JS, Thygesen K, Antman E, Bassand JP (2000) Myocardial infarction redefined-a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 36:959-969
24. Wilder RL, Lafyatis R, Roberts AB et al. (1990) Transforming growth factor-b in rheumatoid arthritis. Ann NY Acad Sci 593:197-207
25. Arlati S, Brenna S, Prencipe L et al. (2000) Myocardial necrosis in ICU patients with acute non-cardiac disease: a prospective study. Intensive Care Med 26:31-37
26. Kumar A, Thota V, Dee L (1996) Tumor necrosis factor-a and interleukin-a-b are responsible for depression of in vitro myocardial cell contractility induced by serum from humans with septic shock. J Exp Med 183:949-958
27. Pathan N, Hemingway CA, Alizadeh AA (2004) Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet 363:203-209
28. Esmon CT (2003) The protein C pathway. Chest 124:26-32
29. Ely EW, Laterre P-F, Angus DC et al. (2003) Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med 31:12-19
30. Abraham E, Laterre P-F, Garg R (2005) Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 353:1332-1341