Seeds and oil of the Styrian oil pumpkin: Components and biological activities

European Journal of Lipid Science and Technology

Volumn 109, Issue 11, 2007, Pages 1128-1140

  Fruhwirth, Gilbert O ^a   Hermetter, Albin ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Benign prostate hyperplasia; Cucurbita pepo; Phenolics; Potyvirus; Tocopherols

Indexed keywords

CUCURBITA; CUCURBITA PEPO; CUCURBITA PEPO SUBSP. PEPO; POTYVIRUS;

EID: 36349029698     PISSN: 14387697     EISSN: 14389312     Source Type: Journal    
DOI: 10.1002/ejlt.200700105     Document Type: Review

References (92)

1. T. C. Andres: Cucurbitaceae and home of the cucurbit network. http://www.cucurbit.org/index.html 2003.
2. T. W. Whitaker, G. N. Davies: Cucurbits. Interscience Publishers Inc., New York, NY (USA) 1962.
3. J. T. Esquinas-Alcazra, P. J. Gulick: Genetic Resources of Cucurbitaceae. International Board for Plant Genet: Resources, Rome (Italy) 1983.
4. G. Madaus: Lehrbuch der biologischen Heilmittel. G. Olms Verlag, Hildesheim (Germany) 1979.
5. H. Brücher: Useful Plants of Neotropical Origin and Their Wild Relatives. Springer Verlag, Berlin, Heidelberg (Germany) 1989.
6. O. I. Sanjur, D. R. Piperno, T. C. Andres, L. Wessel-Beaver: Phylogenetic relationships among domesticated and wild species of Cucurbita (Cucurbitaceae) inferred from a mitochondrial gene: Implications for crop plant evolution and areas of origin.Proc Nat Acad Sci USA 2002, 99, 535-540.
7. S. G. Stuart: Comparative biochemical and genetic studies of testa development in normal and null-less phenotypes of pumpkin (Cucarbita pepo). PhD Thesis, University of New Hampshire, New Hampshire (USA) 1983.
8. J. B. Loy: Seed development in Cucurbita pepo: An overview with emphasis on hull-less seeded genotypes of pumpkin. Cucurbit Genet Coop Rep. 2000, 23, 89-95.
9. J. B. Loy: Morpho-physiological aspects of productivity and quality in squash and pumpkins (Cucurbita spp.). Crit Rev Plant Sci. 2004, 23, 337-363.
10. S. G. Stuart, J. B. Loy: Comparison of testa development in normal and hull-less seeded strains of Cucurbita pepo. Bot Gaz. 1983, 144, 491-500.
11. S. G. Stuart, J. B. Loy: Changes in testa composition during seed development in Cucurbita pepo. Plant Physiol. 1988, 7, 191-195.
12. T. N. Bezold, J. B. Loy, S. C. Minocha: Changes in the cellular content of polyamines in different tissues of seed and fruit of a normal and a hull-less seed variety of pumpkin during development. Plant Sci. 2003, 164, 743-752.
13. T. N. Bezold, D. Mathews, J. B. Loy, S. C. Minocha: Molecular analysis of the hull-less seed trait in pumpkin: Expression profiles of genes related to seed coat development. Seed Sci Res. 2005, 15, 205-217.
14. Z. Matus, P. Molnár, L. G. Szabó: Main carotenoids of pumpkin (Curcurbita pepo pepo Styriaca) oil press cake. Acta Pharm Hung. 2001, 63, 247-256.
15. K. Perscha: Erntebilanz 2006 der Landwirtschaftskammer Steiermark. http://Stmk.Agrarnet.Info/2006.
16. M. Murkovic, A. Hillebrand, J. Winkler, E. Leitner, W. Pfannhauser: Variability of fatty acid content in pumpkin seeds (Cucurbita pepo L.). Z Lebensm Unters Forsch. 1996, 203, 216-219.
17. A. Idouraine, E. A. Kohlhepp, C. W. Weber, W. A. Warid, J. J. Martinez-Tellez: Nutrient constituents from eight lines of naked seed squash (Cucurbita pepo L.). J Agric Food Chem. 1996, 44, 721-724.
18. A. Polanowski, E. Cieslar, J. Otlewski, B. Nienartowicz, A. Wilimowska-Pelc, T. Wilusz: Protein inhibitors of trypsin from the seeds of Cucurbitaceae plants. Acta Biochim Pol. 1987, 34, 395-406.
19. E. H. Mansour, E. Dworschak, A. Gasi, E. Barna, A. Gergely: Nutritive value of pumpkin (Cucurbita pepo Kakai 35) seed products. J Sci Food Agric. 1993, 61, 73-78.
20. G. Schilcher: Cucarbita species. Z Phytother. 1986, 7, 19-25.
21. L. Brühl: Determination of trans fatty acids in cold pressed oils and in dried seeds. Fett/Lipid 1996, 98, 380-383.
22. G. O. Fruhwirth, T. Wenzl, R. El-Toukhy, F. S. Wagner, A. Hermetter: Fluorescence screening of antioxidant capacity in pumpkin seed oils and other natural oils. Eur J Lipid Sci Technol. 2003, 105, 266-274.
23. Ch. Wentzel: Fatty acid composition of Styrian pumpkin seed oils. Ernährung/Nutrition 1987, 11, 752-755.
24. W. Schuster, W. Zipse, R. Marquard: Effect of genotype and place of cultivation on various ingredients of oil-gourd seeds (Cucurbita pepo L.). Fette Seifen Anstrichm. 1983, 85, 56-64.
25. R. Marquard: Der Einfluss von Standardfaktoren und spezifischen Klimakonstellationen auf Fettgehalt, Fettsäurezusammensetzung und Tocopherolgehalt von Raps, Sonnenblumen Soja und Lein. Habilitation Thesis, Justut-Liebig Universität Gießen, Gießen (Germany) 1980.
26. H. Yoshida, Y. Shougaki, Y. Hirakawa, Y. Tomiyama, Y. Mizushina: Lipid classes, fatty acid composition and triacylglycerol molecular species in the kernels of pumpkin (Cucurbita spp) seeds. J Sci Food Agric. 2004, 84, 158-163.
27. M. Murkovic, V. Piironen, V. Lampi, T. Kraushofer, G. Sontag: Changes in chemical composition of pumpkin seeds during the roasting process for production of pumpkin seed oil Part 1: Non-volatile compounds. Food Chem. 2004, 84, 359-365.
28. A. Azzi, R. Gysin, P. Kempná, R. Ricciarelli, L. Villacorta, J. M. Zingg, V. Zingg: Regulation of gene and protein expression by vitamin E. Free Radic Res. 2003, 36, 30-35.
29. M. Murkovic, A. Hillebrand, J. Winkler, W. Pfannhauser: Variability of vitamin E content in pumpkin seeds (Cucurbita pepo L.). Z Lebensm Unters Forsch. 1996, 202, 275-278.
30. Z. J. Suturovic, N. J. Marjanovic: Chronopotentiometric study of tocopherols in vegetable oils. Electroanalysis 1998, 11, 207-209.
31. R Vogel: Studies of pumpkin seed oil. Fette Seifen Anstrichm. 1977, 80, 315-317.
32. I. Juranovic, P. Breinhölder, I. Steffan: Detemination of trace elements in pumpkin seed oils and pumkin seeds by ICP-AES. J Anal At Spectrom. 2003, 18, 54-58.
33. I. Kreft, V. Stibilj, Z. Trkov: Iodine and selenium contents in pumpkin (Cucurbita pepo L.) oil and oil-cake. Eur Food Res Technol. 2002, 215, 279-281.
34. P. Smrkolj, V. Stibilj, I. Kreft, E. Kapoln: Selenium species determination in selenium-enriched pumpkin (Cucurbita pepo L.) seeds by HPLC-UV-HG-AFS. Anal Sci. 2005, 21, 1501-1504.
35. A. Mandl, G. Reich, W. Lindner: Detection of adulteration of pumpkin seed oil by analysis of content and composition of specific Δ7-phytosterols. Eur Food Res Technol. 1998, 209, 400-406.
36. H.-W. Rauwald, M. Sauter, H. Schilcher: A 24-β-ethyl-Δ7-steryl glucopyranoside from Cucurbita pepo seeds. Phytochemistry 1985, 24, 2746-2748.
37. T. Wenzl, E. Prettner, K. Schweiger, F. S. Wagner: An improved method to discover adulteration of Styrian pumpkin seed oil. J Biochem Biophys Methods 2002, 53, 193-202.
38. J. E. Spangenberg, N. Ogrinc: Authentication of vegetable oils by bulk and molecular carbon isotope analysis with emphasis on olive oil and pumpkin seed oil. J Agric Food Chem. 2001, 49, 1534-1540.
39. R. K. Ellsworth: Simple method for separation of milligram quantities of protochlorophyll a from seed oils in extracts of whole pumpkin seeds. Anal Biochem. 1970, 39, 540-542.
40. B. Schoefs: Analysis of pigments in pumpkin-seed oil. Lebensm Biotechnol. 2001, 18, 8-10.
41. E. Lankmayr, J. Mocak, K. Serdt, B. Balla, T. Wenzl, D. Bandoniene, M. Gfrerer, S. Wagner: Chemometrical classification of pumpkin seed oils using UV-Vis, NIR and FTIR spectra. J Biochem Biophys Methods 2004, 61, 95-106.
42. B. Siegmund, M. Murkovic: Changes in chemical composition of pumpkin seeds during the roasting process for production of pumpkin seed oil. Part 2: Volatile compounds. Food Chem. 2004, 84, 367-374.
43. T. Matsui, H. Guth, W. Grosch: A comparative study of potent odorants in peanut, hazelnut, and pumpkin seed oils on the basis of aroma extract dilution analysis (AEDA) and gas chromatography-olfactometry of headspace samples (GCOH). Fett/Lipid 1997, 100, 51-56.
44. H. Adlercreutz, W. Mazur: Phyto-oestrogens and western diseases. Ann Med. 1997, 29, 95-120.
45. L. U. Thompson, M. M. Seidl, S. E. Rickards, L. G. Orcheson, H. H. S. Fong: Antitumorigenic effect of a mammalian lignan precursor from flaxseed. Nutr Cancer 1996, 26, 159-165.
46. T. Sicilia, H. B. Niemeyer, D. M. Honig, M. Metzler: Identification and stereochemical characterization of lignans in flaxseed and pumpkin seeds. J Agric Food Chem. 2003, 51, 1181-1188.
47. G. O. Fruhwirth, F. S. Wagner, A. Hermetter: The αPROX assay: Fluorescence screening of the inhibitory effects of hydrophilic antioxidants on protein oxidation. Anal Bioanal Chem. 2006, 384, 703-712.
48. W. Li, K. Koike, M. Tatsuzaki, A. Koide, T. Nikaido: Cucurbitosides F-M, acylated phenolic glycosides from the seeds of Cucurbita pepo. J Nat Prod. 2005, 68, 1754-1757.
49. V. Lisa, G. Boccardo, G. d'Agostino, G. Dellavalle, M. d'Aquilio: Characterization of a potyvirus that causes zucchini yellow mosaic. Phytopathology 1981, 71, 667-672.
50. J. Weber: Kürbisanbau nur mit virusfreiem Saatgut. Der Fortschrittliche Landwirt 1998, 3, 10-11.
51. I. Tobias, L. Palkovics: Characterization of Hungarian isolates of zucchini yellow mosaic virus (ZYMV, potyvirus) transmitted by seeds of Cucurbita pepo var Styriaca. Pest Manag Sci. 2003, 59, 493-497.
52. Z. Basky, T. M. Perring, I. Tobias: Spread of zucchini yellow mosaic virus in squash in Hungary. J Appl Entomol. 2001, 125, 271-275.
53. C. Schrijnwerkers, N. Huijbert, L. Bos: Zucchini yellow mosaic virus; two outbreaks in the Netherlands and seed transmissibility. Neth J Plant Pathol. 1991, 97, 187-191.
54. J. D. Fletcher, A. R. Wallace, B. T. Rogers: Potyviruses in New Zealand buttercup squash (Cucurbita maxima Duch): Yield and quality effects of ZYMV and WMV2 virus infection. N Z J Crop Hort Sci. 2000, 28, 17-26.
55. I. Tobias, G. Kovacs: Seed transmission of zucchini yellow mosaic virus - new viral pathogen on cucurbitaceous plants. Plant Prot. 2001, 37, 29-31.
56. B. Zechmann, M. Müller, G. Zellnig: Cytological modifications in zucchini yellow mosaic virus (ZYMV)-infected Styrian pumpkin plants. Arch Virol. 2003, 148, 1119-1133.
57. G. Gullner, T. Kömives: The Role of Glutathione and Glutathione-related Enzymes in Plant-Pathogen Interaction. Kluwer Academic Publishers, Dordrecht (The Netherlands) 2001.
58. M. Riedle-Bauer: Role of reactive oxygen species and antioxidant enzymes in systemic virus infection of plants. J Phytopathol. 2000, 148, 297-302.
59. B. Zechmann, G. Zellnig, M. Müller: Changes in the subcellular distribution of glutathione during virus infection in Cucurbita pepo. Plant Biol. 2005, 7, 49-57.
60. S. Vidal, U. Kuhlmann, C. R. Edwards: Western Corn Rootworm: Ecology and Management. CABI Publishing, Wallingford (UK) 2005.
61. M. P. Hoffman, R. W. Robinson, M. M. Kyle, J. J. Kirkwyland: Defoliation and infestation of Cucurbita pepo genotypes by diabroticite beetles. Hort Sci. 1996, 31, 439-442.
62. H. E. Hummel, G. Urek, S. Modic, D. F. Hein: Monitoring presence and advance of the alien invasive western corn rootworm beetle in eastern Slovenia with highly sensitive Metcalf traps. Commun Agric Appl Biol Sci. 2005, 70, 687-692.
63. J. V. Svarc-Gakic, Z. J. Suturovic, N. J. Marjanovic, S. Z. Kravic: Determination of As(III) and As(V) in oilseeds by chronopotiometric stripping analysis: Development of a method. Mol Nutr Food Res. 2005, 49, 337-342.
64. M. Gfrerer, M. Zischka: Analysis of pumpkin seeds and oils. GIT Labor Fachzeitschrift 2003, 3, 283-286.
65. S. Ecker, O. Horak: Pathways of HCB-contamination to oil pumpkin seeds. Chemosphere 1994, 29, 2135-2145.
66. M. I. Mattina, B. D. Eitzer, W. Ianucci-Berger, W.-Y. Lee, J. C. White: Plant uptake and translocation of highly weathered, soil-bound technical chlordane residues: Data from field and rhizotron studies. Environ Toxicol Chem. 2007, 23, 2756-2762.
67. M. I. Mattina, W. Ianucci-Berger, B. D. Eitzer, J. C. White: Rhizotron study of Cucurbitaceae: Transport of soil bound chlordane and heavy metal contaminants differ with genera. Environ Chem. 2004, 1, 86-89.
68. J. C. White, X. Wang, M. P. N. Gent, W. Ianucci-Berger, B. D. Eitzer, N. P. Schultes, M. Arienzo, M. I. Mattina: Subspecies-level variation in the phytoextraction of weathered p,p′-DDE by Cucurbita pepo. Environ Sci Technol. 2003, 37, 4368-4373.
69. J. C. White, Z. D. Parrish, M. P. N. Gent, W. Ianucci-Berger, B. D. Eitzer, M. Isleyen, M. J. I. Mattina: Soil amendments, plant age, and intercropping impact p,p′-DDE bioavailability to Cucurbita pepo. J Environ Qual. 2006, 35, 992-1000.
70. J. W. Kelsey, A. Colino, M. Koberle, J. C. White: Growth conditions impact 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p′-DDE) accumulation by Cucurbita pepo. Int J Phytoremediation 2006, 8, 261-271.
71. M. Gfrerer, E. Lankmayr: Microwave-assisted saponification for the determination of 16 polycyclic aromatic hydrocarbons from pumpkin seed oil. J Sep Sci. 2003, 26, 1230-1236.
72. C. P. Marinangeli, K. A. Vaady, P. J. Jones: Plant sterols combined with exercise for the treatment of hypercholesterolemia: Overview of independent and synergistic mechanisms of action. Nutr Biochem. 2006, 17, 217-224.
73. K. G. Moruisi, W. Osthuizen, A. M. Opperman: Phytosterols/stanols lower cholesterol concentrations in familial hypercholersterolemic subjects: A systematic review with meta-analysis. J Am Coll Nutr.2006, 25, 41-48.
74. R. E. Ostlund, X. Lin: Regulation of cholesterol absorption by phytosterols. Curr Atherosc Rep. 2006, 8, 487-491.
75. S. E. Bulun, K. Zeitoun, H. Sasano, E. R. Simpson: Aromatase in aging women. Semin Reprod Endocrinol. 1999, 17, 349-358.
76. H. Weisser, M. Krieg: Benign prostatic hyperplasia - the outcome of age-induced alteration of androgen-estrogen balance? Urologe A 1997, 36, 3-9.
77. H. Weisser, M. Krieg: Kinetic analysis of androstenedione 5 alpha-reductase in epithelium and stroma of human prostate. Steroids 1997, 62, 589-594.
78. C. B. Schmidlin, M. H. Kreuter: Möglicher Einfluß auf hormonelle Ungleichgewichte bei Inkontinenz. ÖAz 2003, 57, 1071-1078.
79. S. E. Bulun, Z. Lin, G. Imir, S. Amin, M. Demura, B. Yilmaz, R. Martin, H. Utsunomiya, S. Thung, B. Gurates, M. Tamura, D. Langoi, S. Deb: Regulation of aromatase expression in estrogen-responsive breast and uterine disease: From bench to treatment. Pharmacol Rev. 2005, 57, 359-383.
80. C. Sultan, A. Terraza, C. Devillier, E. Carilla, M. Briley, C. Loire, B. Descomps: Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts. J Steroid Biochem. 1984, 20, 515-519.
81. E. Carilla, M. Briley, F. Fauran, Ch. Sultan, C. J. Duvillier: Binding of Permixon, a new treatment for prostatic benign hyperplasia, to the cytosolic androgen receptor in the rat prostate. J Steroid Biochem. 1984, 20, 521-526.
82. R. Nitsch-Fitz, H. Egger, H. Wutzl, H. Maruna: Einsatz des Kürbiskern-Diätetikums "Kürbis-Granufink" bei Patienten mit Prostatahypertrophie in Wiener Allgemeinpraxen. Ehk 1979, 12, 1009-1013.
83. H. Schlichen U. Dunzendorfer, F. Ascali: Δ7-Sterols: The prostatotropic principle of pumpkin seeds? Urologe B 1987, 27, 316-319.
84. E. Bombardelli, E. Frangi, A. Moggi: US Patent 554773 (1996).
85. B.-E. Carbin, B. Lasson, O. Lindahl: Treatment of benign prostate hyperplasia with phytosterols. Br J Urol. 1990, 66, 639-644.
86. M. Friedrich, C. Theurer, G. Schiebl-Schlosser: Prosta Fink Forte-Kapseln in der Behandlung der benignen Prostatahyperplasie. Forsch Komplementarmed. 2000, 7, 200-204.
87. D. G. Hatzchristo, C. E. Constantiou: Adrenergic and hormonal stimulation produces an increase in the prostate and bladder weight. Neurourol Urodyn. 1995, 14, 467-469.
88. J. Z. Lee, S. Omata, B. Tillig, I. Perkash, C. E. Constantiou: Chronology and urodynamic characterization of micturition in neurohormonally induced experimental prostate growth in the rat. Neurourol Urodyn. 1998, 17, 55-69.
89. Y.-S. Tsai, Y.-C. Tong, J.-T. Cheng, C.-H. Lee, F.-S. Yang, H.-Y. Lee: Pumpkin seed oil and phytersterol-F can block testosteron/prazosin-induced prostate growth in rats. Urol Int. 2006, 77, 269-274.
90. R. E. Ostlund, Jr., J. B. McGill, C. M. Zeng, D. F. Covey, J. Stearns, W. F. Stenson, C. A. Spilburg: Gastrointestinal absorption and plasma kinetics of soy Delta 5-phytosterols and phytostanols in humans. Am J Physiol Endocrinol Metab. 2002, 282, E911-E916.
91. J. Janick, H. Paris: The cucurbit images (1515-15-18) of the Villa Farnesina, Rome. Ann Bot. 2006, 97, 165-176.
92. Deutsche Gesellschaft für Ernährung: Empfehlungen für die Nährstoffzufuhr. DGE e.V., Frankfurt (Germany) 1991.