Immune response to Candida albicansis preserved despite defect in O-mannosylation of secretory proteins

Medical Mycology

Volumn 45, Issue 8, 2007, Pages 709-719

  Corbucci, Cristina ^a   Cenci, Elio ^a   Skrzypek, Franck ^a   Gabrielli, Elena ^a   Mosci, Paolo ^a   Ernst, Joachim ^b   Bistoni, Francesco ^a   Vecchiarelli, Anna ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

C. albicans; Fungi; Innate immunity; Macrophages; TLR

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANNOSYLTRANSFERASE; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOLIPASE; PROTEIN PMT2; PROTEIN PMT5; PROTEINASE; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS HYPHAE; IMMUNE RESPONSE; INNATE IMMUNITY; KIDNEY; MACROPHAGE; MOUSE; MYCELIUM; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION;

ANIMALS; BLOTTING, WESTERN; CANDIDA ALBICANS; CANDIDIASIS; FEMALE; HISTOCYTOCHEMISTRY; IMMUNITY, NATURAL; INTERLEUKIN-10; INTERLEUKIN-12; KIDNEY; MACROPHAGES, PERITONEAL; MANNOSYLTRANSFERASES; MICE; MUTATION; PEPTIDE HYDROLASES; PHAGOCYTOSIS; PHOSPHOLIPASES; TOLL-LIKE RECEPTOR 4; VIRULENCE;

ANIMALIA; CANDIDA; CANDIDA ALBICANS; FUNGI;

EID: 36349026387     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.1080/13693780701537922     Document Type: Article

References (31)

1. Ernst, JF and Prill, SK. (2001) O-glycosylation. Med Mycol, 39, pp. 67-74.
2. Strahl-Bolsinger, S., Gentzsch, M. and Tanner, W. (1999) Protein O-mannosylation. Biochim Biophys Acta, 1426, pp. 297-307.
3. Strahl-Bolsinger, S. and Scheinost, A. (1999) Transmembrane topology of pmt1p, a member of an evolutionarily conserved family of protein O-mannosyltransferases. J Biol Chem, 274, pp. 9068-9075.
4. Prill, SK, Klinkert, B. and Timpel, C. (2005) PMT family of Candida albicans: Five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance. Mol Microbiol, 55, pp. 546-560.
5. Rouabhia, M., Schaller, M. and Corbucci, C. (2005) Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases. Infect Immun, 73, pp. 4571-4580.
6. Timpel, C., Strahl-Bolsinger, S., Ziegelbauer, K. and Ernst, JF. (1998) Multiple functions of Pmt1p-mediated protein O-mannosylation in the fungal pathogen Candida albicans. J Biol Chem, 273, pp. 20837-20846.
7. Timpel, C., Zink, S., Strahl-Bolsinger, S., Schroppel, K. and Ernst, J. (2000) Morphogenesis, adhesive properties, and antifungal resistance depend on the Pmt6 protein mannosyltransferase in the fungal pathogen Candida albicans. J Bacteriol, 182, pp. 3063-3071.
8. De Bernardis, F., Sullivan, PA and Cassone, A. (2001) Aspartyl proteinases of Candida albicans and their role in pathogenicity. Med Mycol, 39, pp. 303-313.
9. Naglik, J., Albrecht, A., Bader, O. and Hube, B. (2004) Candida albicans proteinases and host/pathogen interactions. Cell Microbiol, 6, pp. 915-926.
10. Schaller, M., Korting, HC, Borelli, C., Hamm, G. and Hube, B. (2005) Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis. Infect Immun, 73, pp. 2758-2765.
11. Agostini, M., Cenci, E. and Pericolini, E. (2005) The glucocorticoid-induced tumor necrosis factor receptor-related gene modulates the response to Candida albicans infection. Infect Immun, 73, pp. 7502-7508.
12. Echevarria, A., Durante, AG, Arechaval, A. and Negroni, R. (2002) [Comparative study of two culture media for the detection of phospholipase activity of Candida albicans and Cryptococcus neoformans strains]. Rev Iberoam Micol, 19, pp. 95-98.
13. Blasi, E., Colombari, B. and Orsi, CF (2004) The human immunodeficiency virus (HIV) protease inhibitor indinavir directly affects the opportunistic fungal pathogen Cryptococcus neoformans. FEMS Immunol Med Microbiol, 42, pp. 187-195.
14. Pietrella, D., Corbucci, C., Perito, S., Bistoni, G. and Vecchiarelli, A. (2005) Mannoproteins from Cryptococcus neoformans promote dendritic cell maturation and activation. Infect Immun, 73, pp. 820-827.
15. Wellington, M., Bliss, JM and Haidaris, CG. (2003) Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment. Infect Immun, 71, pp. 7228-7231.
16. Cenci, E., Romani, L. and Mencacci, A. (1993) Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans. Eur J Immunol, 23, pp. 1034-1038.
17. D'Ostiani, CF, Sero, G Del and Bacci, A. (2000) Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J Exp Med, 191, pp. 1661-1674.
18. Pietrella, D., Bistoni, G., Corbucci, C., Perito, S. and Vecchiarelli, A. (2006) Candida albicans mannoprotein influences the biological function of dendritic cells. Cell Microbiol, 8, pp. 602-612.
19. Roeder, A., Kirschning, CJ, Rupec, RA, Schaller, M. and Korting, HC. (2004) Toll-like receptors and innate antifungal responses. Trends Microbiol, 12, pp. 44-49.
20. van der Graaf, CA, Netea, MG, Verschueren, I., van der Meer, JW and Kullberg, BJ. (2005) Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae. Infect Immun, 73, pp. 7458-7464.
21. Ashman, RB and Papadimitriou, JM. (1995) Production and function of cytokines in natural and acquired immunity to Candida albicans infection. Microbiol Rev, 59, pp. 646-672.
22. Netea, MG, Stuyt, RJ and Kim, SH (2002) The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures. J Infect Dis, 185, pp. 963-970.
23. Moragues, MD, Omaetxebarria, MJ and Elguezabal, N. (2003) A monoclonal antibody directed against a Candida albicans cell wall mannoprotein exerts three anti-C. albicans activities. Infect Immun, 71, pp. 5273-5279.
24. Blasi, E., Pitzurra, L., Bartoli, A., Puliti, M. and Bistoni, F. (1994) Tumor necrosis factor as an autocrine and paracrine signal controlling the macrophage secretory response to Candida albicans. Infect Immun, 62, pp. 1199-1206.
25. Mansour, MK and Levitz, SM. (2002) Interactions of fungi with phagocytes. Curr Opin Microbiol, 5, pp. 359-365.
26. Roeder, A., Kirschning, CJ and Rupec, RA (2004) Toll-like receptors as key mediators in innate antifungal immunity. Med Mycol, 42, pp. 485-498.
27. Palma, C., Serbousek, D., Torosantucci, A., Cassone, A. and Djeu, JY. (1992) Identification of a mannoprotein fraction from Candida albicans that enhances human polymorphonuclear leukocyte (PMNL) functions and stimulates lactoferrin in PMNL inhibition of candidal growth. J Infect Dis, 166, pp. 1103-1112.
28. Engstad, CS, Engstad, RE, Olsen, JO and Osterud, B. (2002) The effect of soluble beta-1,3-glucan and lipopolysaccharide on cytokine production and coagulation activation in whole blood. Int Immunopharmacol, 2, pp. 1585-1597.
29. Tonnetti, L., Spaccapelo, R. and Cenci, E. (1995) Interleukin-4 and -10 exacerbate candidiasis in mice. Eur J Immunol, 25, pp. 1559-1565.
30. Netea, MG, Gow, NA and Munro, CA (2006) Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J Clin Invest, 116, pp. 1642-1650.
31. Fonzi, WA and Irwin, MY. (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics, 134, pp. 717-728.