Uncontrolled thrombocytosis in polycythemia vera is a risk for thrombosis, regardless of JAK2V617F mutational status [4]

Leukemia

Volumn 21, Issue 12, 2007, Pages 2544-2545

  Ohyashiki, K ^a   Akahane, D ^a   Gotoh, A ^a   Ito, Y ^a   Tauchi, T ^a   Miyazawa, K ^a   Kimura, Y ^a   Ohyashiki, J H ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; HYDROXYUREA; JANUS KINASE 2;

ADULT; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FEMALE; GENE MUTATION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; LETTER; MALE; PHLEBOTOMY; POLYCYTHEMIA VERA; PRIORITY JOURNAL; RISK ASSESSMENT; THROMBOCYTE COUNT; THROMBOCYTOSIS; THROMBOSIS; TREATMENT FAILURE;

EID: 36349025806     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404829     Document Type: Letter

References (8)

1. Schafer AI. Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia. Blood 2006; 107: 4214-4222.
2. Scott LM, Tong W, Levine RL, Scott MA, Beer PA, Stratton MR et al. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med 2007; 356: 459-468.
3. V617F mutational status as determined by semiquantitative sequence-specific primer-single molecule fluorescence detection assay is linked to clinical features in chronic myeloproliferative disorders. Leukemia 2007; 21: 1097-1099.
4. Campbell PJ, Scott LM, Buck G, Wheatley K, Easy CL, Marsden JT et al. Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: A prospective study. Lancet 2005; 366: 1945-1953.
5. V617F in polycythemia vera. Cancer 2006; 106: 631-635.
6. Di Nisio M, Barbui T, Di Gennaro L, Borrelli G, Finazzi G, Landolfi R. The haematocrit and platelet target in polycythemia vera. Br J Haematol 2007; 136: 249-259.
7. V617F mutation status. Haematologica 2007; 92: 135-136.
8. V617F mutation in patients with polycythemia vera or essential thrombocythemia. Blood 2007, E-pub ahead of print, 22 March.