Familial combined hyperlipidaemia: How can genetic disorders be common, complex and comprehensible?

Clinical Science

Volumn 113, Issue 9-10, 2007, Pages 365-367

  Sniderman, Allan ^a   Bailey, Swneke D ^a   Engert, Jamie C ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Apolipoprotein B (apoB); Familial combined hyperlipidaemia (FCHL); Hypertriglyceridaemia; Lipid phenotype; Lipoprotein; Liver; Steatosis

Indexed keywords

ALANINE AMINOTRANSFERASE; APOLIPOPROTEIN B; CHOLESTEROL; FATTY ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ABDOMINAL OBESITY; ADIPOSE TISSUE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; DISEASE ASSOCIATION; FAMILIAL HYPERLIPEMIA; FATTY ACID ANALYSIS; GENETIC DISORDER; GENOTYPE ENVIRONMENT INTERACTION; HEALTH CARE UTILIZATION; HUMAN; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; LIPOPROTEIN BLOOD LEVEL; LONGITUDINAL STUDY; METABOLISM; MULTIGENE FAMILY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; TIME; TRIACYLGLYCEROL BLOOD LEVEL;

APOLIPOPROTEINS B; HUMANS; HYPERLIPIDEMIA, FAMILIAL COMBINED; MODELS, GENETIC; MULTIFACTORIAL INHERITANCE; PHENOTYPE;

EID: 36349015989     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20070220     Document Type: Review

References (8)

1. Goldstein, J. L., Schrott, H. G., Hazzard, W. R., Biermann, E. L. and Motulsky, A. G. (1973) Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J. Clin. Invest. 52, 1544-1568
2. Suviolahti, E., Lilja, H. E. and Pajukanta, P. (2006) Unraveling the complex genetics of familial combined hyperlipidemia. Ann. Med. 38, 337-351
3. Brouwers, M. C. G. J., van Greevenbroek, M. M. J., Vermeulen, V. M. M.-J., van Lin, J. M. J. P., van der Kallen, C. J. H. and de Bruin, T. W. A. (2007) Five-year follow-up circumference, insulin and ALT levels in familial combined hyperlipidemia. Clin. Sci. 113, 375-381
4. Veerkamp, M. J., de Graaf, J., Hendriks, J. C., Demacker, P. N. and Stalenhoef, A. F. (2004) Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study. Circulation 109, 2980-2985
5. de Graaf, J., Veerkamp, M. J. and Stalenhoef, A. F. (2002) Metabolic pathogenesis of familial combined hyperlipidaemia with emphasis on insulin resistance, adipose tissue metabolism and free fatty acids. J. R. Soc. Med. 12 (Suppl.), 46-53
6. Sniderman, A. D., Zhang, X. J. and Cianflone, K. (2000) Governance of the concentration of plasma LDL: a reevaluation of the LDL receptor paradigm. Atherosclerosis 148, 215-229
7. ter Avest, E., Sniderman, A. D., Bredie, S. J. H., Wiegman, A., Stalenhoef, A. F. H. and de Graaf, J. (2007) Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia. Clin. Sci. 112, 113-139
8. Smith, J., Al-Amri, M., Dorairaj, P. and Sniderman, A. (2006) The adipocyte life cycle hypothesis. Clin. Sci. 110, 1-9