Antinociceptive Synergistic Interaction Between Clonidine and Ouabain on Thermal Nociceptive Tests in the Rat

Journal of Pain

Volumn 8, Issue 12, 2007, Pages 983-988

  Zeng, Weian ^a   Chen, Xiangnan ^a   Dohi, Shuji ^b  

^a Tumor Hospital   (China)

^b GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

2 adrenergic agonists; Analgesia; ion channels

Indexed keywords

CLONIDINE; OUABAIN;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; LATENT PERIOD; MALE; MOTOR DYSFUNCTION; NOCICEPTIVE STIMULATION; NONHUMAN; RAT; TAIL FLICK TEST; THERMAL STIMULATION;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; CLONIDINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME INHIBITORS; HYPERALGESIA; MALE; OUABAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; TIME FACTORS;

EID: 36349005728     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2007.07.006     Document Type: Article

References (29)

1. Abelson K.S., and Hoglund A.U. The effects of the alpha2-adrenergic receptor agonists clonidine and rilmenidine, and antagonists yohimbine and efaroxan, on the spinal cholinergic receptor system in the rat. Basic Clin Pharmacol Toxicol 94 (2004) 153-160
2. 2+-independent release of acetylcholine evoked by veratridine, ouabain and alpha-latrotoxin: Possible role of [Na+]i. J Physiol Paris 87 (1993) 43-50
3. Benjamin A.M., and Quastel J.H. Location of amino acids in brain slices from the rat. J Biochem 28 (1972) 631-646
4. Berenbaum M.C. What is synergy?. Pharmacol Rev 41 (1989) 93-141
5. Blasi J.M., Cena V., Gonzalez-Garcia C., Marsal J., and Solsona C. Ouabain induces acetylcholine release from pure cholinergic synaptosomes independently of extracellular calcium concentration. Neurochem Res 13 (1988) 1035-1041
6. Blaustein M.P. The cellular basis of cardiotonic steroid action. Trends Pharmacol Sci 7 (1985) 289-292
7. Bonnet F., Boico O., Rostaing S., Saada M., Loriferne J.F., Touboul C., Abhay K., and Ghignone M. Postoperative analgesia with extradural clonidine. Br J Anaesth 63 (1989) 465-469
8. Carmichael F.J., and Israel Y. Effects of ethanol of neurotransmitter release by brain cortical slices. J Pharmacol Exp Ther 193 (1975) 824-834
9. Detweiler D.J., Eisenach J.C., Tong C., and Jackson C. A cholinergic interaction in alpha 2 adrenoceptor-mediated antinociception in sheep. J Pharmacol Exp Ther 265 (1993) 536-542
10. Dohi S. Spinal antinociception. Curr Opin Anaesthesiol 9 (1996) 404-409
11. Garcia A.G., and Kirpekar S.M. Inhibition of Na, K-activated ATPase and release of neurotransmitters. Nature 257 (1975) 722
12. Gomez M.V., Diniz C.R., and Barbosa T.S. A comparison of the effects of scorpion venom Tityus toxin and ouabain on the release of acetylcholine from incubated slices of rat brain. J Neurochem 24 (1975) 331-336
13. +-ATPase mRNA and ouabain binding in spinal cord ventral horn. J Neurochem 63 (1994) 1962-1970
14. Honda K., Koga K., Moriyama T., Koguchi M., Takano Y., and Kamiya H.O. Intrathecal alpha2 adrenoceptor agonist clonidine inhibits mechanical transmission in mouse spinal cord via activation of muscarinic M1 receptors. Neurosci Lett 322 (2002) 161-164
15. Katsuragi T., and Furukawa T. Cholinergic potentiation by ouabain in the contraction of guinea-pig vas deferens through pre- and post-synaptic mechanism. Arch Int Pharmacodyn Ther 238 (1979) 4-13
16. Klimscha W., Tong C., and Eisenach J.C. Intrathecal alpha 2-adrenergic agonists stimulate acetylcholine and norepinephrine release from the spinal cord dorsal horn in sheep: An in vivo microdialysis study. Anesthesiology 87 (1997) 110-116
17. Langerman L., Grant G.J., Zakowski M., Golomb E., Ramanathan S., and Turndorf H. Prolongation of epidural anesthesia using a lipid drug carrier with procaine, lidocaine, and tetracaine. Anesth Analg 75 (1992) 900-905
18. 2 receptor systems. Anesthesiology 80 (1994) 1338-1348
19. + ATPase activity and acetylcholine release in rat cortical synaptosomes. J Neurochem 36 (1981) 467-475
20. Robertson A., Day B., Pollock M., and Collier P. The neuropathy of elderly mice. Acta Neuropathol 86 (1993) 163-171
21. Roerig S.C., and Fujimoto J.M. Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice. J Pharmacol Exp Ther 249 (1989) 762-768
22. Satoh E., and Nakazato Y. On the mechanism of ouabain-induced release of acetylcholine from synaptosomes. J Neurochem 58 (1992) 1038-1044
23. Solomon R.E., and Gebhart G.F. Synergistic antinociceptive interactions among drugs administered to the spinal cord. Anesth Analg 78 (1994) 1164-1172
24. Tallarida R.J., Porreca F., and Cowan A. Statistical analysis of drug-drug and site-site interactions with isobolograms. Life Sci 45 (1989) 947-961
25. Vyas S., and Marchbanks R.M. The effect of ouabain on the release of [14C] acetylcholine and other substances from synaptosomes. J Neurochem 37 (1981) 1467-1474
26. Xu Z., Chen S.R., Eisenach J., and Pan H.L. Role of spinal muscarinic and nicotinic receptors in clonidine-induced nitric oxide release in a rat model of neuropathic pain. Brain Res 861 (2000) 390-398
27. Yaksh T.L., and Reddy S.V. Studies in the primate on the analgesic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen. Anesthesiology 54 (1981) 451-467
28. Yaksh T.L., and Wilson P.R. Spinal serotonin terminal systems mediate antinociception. J Pharmacol Exp Ther 208 (1979) 446-453
29. + pump inhibitor ouabain and its interaction with morphine and lidocaine in rats. Anesthesiology 90 (1999) 500-508