Caenorhabditis elegans LET-767 is able to metabolize androgens and estrogens and likely shares common ancestor with human types 3 and 12 17β-hydroxysteroid dehydrogenases

Journal of Endocrinology

Volumn 195, Issue 2, 2007, Pages 271-279

  Desnoyers, Serge ^a   Blanchard, Pierre Gilles ^a   St Laurent, Jean François ^a   Gagnon, Steve N ^a   Baillie, David L ^b   Luu The, Van ^a  

^a LAVAL UNIVERSITY   (Canada)

^b SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANDROGEN; ANDROSTENEDIONE; CAENORHABDITIS ELEGANS PROTEIN; ESTRADIOL; ESTROGEN; ESTRONE; METHIONINE; PROTEIN LET 767; RNA; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CAENORHABDITIS ELEGANS; CATALYSIS; CONTROLLED STUDY; EMBRYO CELL; ENZYME STRUCTURE; GENE MUTATION; GENETIC TRANSFECTION; HORMONE METABOLISM; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

17-HYDROXYSTEROID DEHYDROGENASES; ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANDROGENS; ANDROSTENEDIONE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CATALYSIS; CELL LINE; CONSERVED SEQUENCE; DNA MUTATIONAL ANALYSIS; ESTRADIOL; ESTROGENS; ESTRONE; EVOLUTION, MOLECULAR; HUMANS; METHIONINE; MUTATION; PHENYLALANINE; RNA INTERFERENCE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TESTOSTERONE; TRANS-SPLICING; TRANSFECTION;

EID: 36348999184     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/JOE-07-0248     Document Type: Article

References (21)

1. Baker ME 2003 Evolution of adrenal and sex steroid action in vertebrates: a ligand-based mechanism for complexity. BioEssays 25 396-400.
2. Bertrand S, Brunet FG, Escriva H, Parmentier G, Laudet V & Robinson-Rechavi M 2004 Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems. Molecular Biology and Evolution 21 1923-1937.
3. Blanchard P-G & Luu-The V 2007 Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17B-hydroxysteroid dehydrogenase. Journal of Endocrinology 194 449-455.
4. Dufort I, Rheault P, Huang X-F, Soucy P & Luu-The V 1999 Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase. Endocrinology 140 568-574.
5. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE & Mello CC 1998 Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 806-811.
6. Geissler WM, Davis DL, Wu L, Bradshaw KD, Patel S, Mendonca BB, Elliston KO, Wilson JD, Russell DW & Andersson S 1994 Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3. Nature Genetics 7 34-39.
7. Hope I 1999 C. elegans: A Practical Approach., Oxford: Oxford University Press.
8. Kuervers LM, Jones CL, O'Neil M & Badhe DL 2003 The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenarhabditis elegans. Molecular Genetics and Genomics 270 121-131.
9. Labrie F, Luu-The V, Lin SX, Labrie C, Simard J, Breton R & Belanger A 1997 The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology. Steroids 62 148-158.
10. Labrie F, Luu-The V, Lin SX, Simard J & Labrie C 2000 Role of 17 beta-hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues. Trends in Endocrinology and Metabolism 11 421-427.
11. Li J, Biswas MG, Chao A, Russell DW & Chory J 1997 Conservation of function between mammalian and plant steroid 5alpha-reductases. PNAS 94 3554-3559.
12. Liu H, Zheng S, Bellemare V, Pelletier G, Labrie F & Luu-The V 2007 Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey. BMC Biochemistry 8 2.
13. Luu-The V 2001 Analysis and characteristics of multiple types of human 17 β-hydra-Kysteroid dehydrogenases. Journal of Steroid Biochemistry and Molecular Biology 76 143-151.
14. Luu-The V, Tremblay P & Labrie F 2006 Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women. Molecular Endocrinology 20 437-443.
15. Merris M, Wadsworth WG, Khamrai U, Bittman R, Chitwood DJ & Lenard J 2003 Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4alpha-methyl sterols. Journal of Lipid Research 44 172-181.
16. Mindnich R, Moller G & Adamski J 2004 The role of 17 beta-hydroxysteroid dehydrogenases. Molecular and Cellular Endocrinology 218 7-20.
17. Nokelainen P, Puranen T, Peltoketo H, Orava M, Vihko P & Vihko R 1996 Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity. European Journal of Biochemistry 236 482-490.
18. Singer B & Kusmierek JT 1982 Chemical mutagenesis. Annual Review of Biochemistry 51 655-693.
19. Stewart HI, O'Neil NJ, Janke DL, Franz NW, Chamberlin HM, Howell AM, Gilchrist EJ, Ha TT, Kuervers LM, Vatcher GP et al. 1998 Lethal mutations defining 112 complementation groups in a 4-5 Mb sequenced region of Caenorhabditis elegans chromosome III. Molecular Genetics and Genomics 260 280-288.
20. Vatcher GP, Barbazuk WB, O'Neil NJ, Marra MA, Ha T & Baillie DL 1999 Identification and characterization of a serine hydroxymethyltransferase isciform in Caenorhabditis briggsae. Gene 230 137-144.
21. Wilson JD 1978 Sexual differentiation. Annual Review of Physiology 40 279-306.