Enterovirus-associated hemophagocytic syndrome in children with malignancy: Report of three cases and review of the literature

European Journal of Pediatrics

Volumn 167, Issue 1, 2008, Pages 97-102

  Katsibardi, Katerina ^a   Moschovi, Maria A ^a   Theodoridou, Maria ^a   Spanakis, Nicholas ^b   Kalabalikis, Panagiotis ^c   Tsakris, Athanassios ^b   Tzortzatou Stathopoulou, Fotini ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

Author keywords

Childhood malignancy; Enterovirus; Hemophagocytic syndrome; Immunoglobulin; Treatment

Indexed keywords

ANTIPICORNAVIRAL AGENT; COXSACKIE VIRUS B3 ANTIGEN; ETOPOSIDE; IMMUNOGLOBULIN; PLECONARIL; STEROID; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; BONE MARROW BIOPSY; CASE REPORT; CLINICAL FEATURE; COXSACKIE VIRUS B3; DIARRHEA; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; ENTEROVIRUS; ENTEROVIRUS INFECTION; FATALITY; FEMALE; FEVER; GENE AMPLIFICATION; GENE SEQUENCE; HEART VENTRICLE FIBRILLATION; HEMOPHAGOCYTIC SYNDROME; HEPATOSPLENOMEGALY; HODGKIN DISEASE; HUMAN; IMMUNE DEFICIENCY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIVER DYSFUNCTION; LIVER FAILURE; LOW DRUG DOSE; MALE; MALIGNANT NEOPLASTIC DISEASE; MULTIPLE ORGAN FAILURE; PANCYTOPENIA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; SINGLE DRUG DOSE; TISSUE INJURY; WEIGHT REDUCTION;

ADOLESCENT; CHILD; ENTEROVIRUS INFECTIONS; FATAL OUTCOME; FEMALE; HUMANS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; LYMPHOMA; MALE; MULTIPLE ORGAN FAILURE;

EID: 36348974603     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-007-0436-9     Document Type: Article

References (26)

1. Arico M, Danesino C, Pende D, Moretta L (2001) Pathogenesis of haemophagocytic lymphohistiocytosis. Br J Haematol 114(4):761-769
2. Barre V, Marret S, Mendel I, Lesesve JF, Fessard CI (1998) Enterovirus-associated haemophagocytic syndrome in a neonate. Acta Paediatr 87(4):469-471
3. Chen CJ, Huang YC, Jaing TH, Hung IJ, Jang CP, Chang LY, Lin TY (2004) Hemophagocytic syndrome: a review of 18 pediatric cases. J Microbiol Immunol Infect 37(3):157-163
4. Chen RL, Su IJ, Lin KH, Lee SH, Lin DT, Chuu WM, Lin KS, Huang LM, Lee CY (1991) Fulminant childhood hemophagocytic syndrome mimicking histiocytic medullary reticulosis. An atypical form of Epstein-Barr virus infection. Am J Clin Pathol 96(2):171-176
5. Close P, Friedman D, Uri A (1990) Viral-associated hemophagocytic syndrome. Med Pediatr Oncol 18(2):119-122
6. Emmenegger U, Spaeth PJ, Neftel AK (2002) Intravenous immunoglobulin for hemophagocytic lymphohistiocytosis? J Clin Oncol 20(2):599-601
7. Freeman B, Rathore MH, Salman E, Joyce MJ, Pitel P (1993) Intravenously administered immune globulin for the treatment of infection-associated hemophagocytic syndrome. J Pediatr 123(3):479-481
8. Fujiwara F, Hibi S, Imashuku S (1993) Hypercytokinemia in hemophagocytic syndrome. Am J Pediatr Hematol Oncol 15(1):92-98
9. Gauvin F, Toledano B, Champagne J, Lacroix J (2000) Reactive hemophagocytic syndrome presenting as a component of multiple organ dysfunction syndrome. Crit Care Med 28(9):3341-3345
10. Heaton DC, Moller PW (1985) Still's disease associated with Coxsackie infection and haemophagocytic syndrome. Ann Rheum Dis 44(5):341-344
11. Henter JI, Elinder G, Ost A (1991) Diagnostic guidelines for hemophagocytic lymphohistiocytosis. The FHL Study Group of the Histiocyte Society. Semin Oncol 18(1):29-33
12. Imashuku S, Hibi S, Todo S (1997) Hemophagocytic lymphohistiocytosis in infancy and childhood. J Pediatr 130(3):352-357
13. Imashuku S, Ueda I, Teramura T, Mori K, Morimoto A, Sako M, Ishii E (2005) Occurrence of haemophagocytic lymphohistiocytosis at less than 1 year of age: analysis of 96 patients. Eur J Pediatr 164(5):315-329
14. Janka GE, Schneider EM (2004) Modern management of children with haemophagocytic lymphohistiocytosis. Br J Haematol 124(1):4-14
15. Letsas KP, Filippatos GS, Delimpasi S, Spanakis N, Kounas SP, Efremidis M, Tsakris A, Kardaras F (2007) Enterovirus-induced fulminant myocarditis and hemophagocytic syndrome. J Infect 54(2):e75-e77
16. Miyahara M, Sano M, Shibata K, Matsuzaki M, Ibaraki K, Shimamoto Y, Tokunaga O (2000) B-cell lymphoma-associated hemophagocytic syndrome: clinicopathological characteristics. Ann Hematol 79(7):378-388
17. Moschovi AM, Katsibardi K, Theodoridou M, Michos AG, Tsakris A, Spanakis N, Tzortzatou-Stathopoulou F (2006) Enteroviral infections in children with malignant disease: a 5-year study in a single institution. J Infect 4 [Epub ahead of print]
18. Nagasawa M, Okawa H, Yata J (1994) Deleterious effects of high dose gamma-globulin therapy on patients with hemophagocytic syndrome. Int J Hematol 60(1):91-93
19. Nahum E, Ben-Ari J, Stain J, Schonfeld T (2000) Hemophagocytic lymphohistiocytic syndrome: unrecognized cause of multiple organ failure. Pediatr Crit Care Med 1(1):51-54
20. Palazzi DL, McClain KL, Kaplan S (2003) Hemophagocytic syndrome in children: an important diagnostic consideration in fever of unknown origin. Clin Infect Dis 36(3):306-312
21. Read SJ, Kurtz JB (1999) Laboratory diagnosis of common viral infections of the central nervous system by using a single multiplex PCR screening assay. J Clin Microbiol 37(5):1352-1355
22. Risdall RJ, McKenna RW, Nesbit ME, Krivit W, Balfour HH Jr, Simmons RL, Brunning RD (1979) Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. Cancer 44(3):993-1002
23. Sekigawa I, Suzuki J, Nawata M, Ikeda K, Koike M, Iida N, Hashinoto H, Oshimi K (2001) Hemophagocytosis in autoimmune disease. Clin Exp Rheumatol 19(3):333-338
24. Takahashi N, Chubachi A, Kume M, Hatano Y, Komatsuda A, Bawabata Y, Yanagiya N, Ichikawa Y, Miura AB, Miura I (2001) A clinical analysis of 52 adult patients with hemophagocytic syndrome: the prognostic significance of the underlying diseases. Int J Hematol 74(2):209-213
25. Takeoka Y, Hino M, Nishi S, Koh KR, Yamane T, Ohta K, Nakamae H, Aoyama Y, Hirose A, Fujino H, Takubo T, Inoue T, Tatsumi N (2001) Virus-associated hemophagocytic syndrome due to rubella virus and varicella-zoster virus dual infection in patient with adult idiopathic thrombocytopenic purpura. Ann Hematol 80(6):361-364
26. Tiab M, Mechinaud F, Harousseau JL (2000) Haemophagocytic syndrome associated with infections. Baillieres Best Pract Res Clin Hematol 13(2):163-178