Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli

FEMS Microbiology Letters

Volumn 277, Issue 2, 2007, Pages 123-132

  Alfredson, David A ^a   Korolik, Victoria ^b  

^a St John of God Pathology   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

Antibiotic; Campylobacter; Mechanisms; Resistance

Indexed keywords

AMINOGLYCOSIDE; AMPICILLIN; ANHYDROTETRACYCLINE; AZITHROMYCIN; BETA LACTAM ANTIBIOTIC; CEPHALOSPORIN; CHLORAMPHENICOL; CHLORTETRACYCLINE; CIPROFLOXACIN; CLARITHROMYCIN; COTRIMOXAZOLE; ENROFLOXACIN; ERYTHROMYCIN; GENTAMICIN; IMIPENEM; LINCOSAMIDE; MACROLIDE; MEROPENEM; MINOCYCLINE; NALIDIXIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TETRACYCLINE; TOBRAMYCIN; TRIMETHOPRIM; TYLOSIN; VIRGINIAMYCIN;

ANTIBIOTIC RESISTANCE; BACTEREMIA; BACTERIAL INFECTION; BACTERIUM ISOLATE; CAMPYLOBACTER; CAMPYLOBACTER COLI; CAMPYLOBACTER JEJUNI; DEVELOPED COUNTRY; DEVELOPING COUNTRY; ESCHERICHIA COLI; GASTROENTERITIS; GRAM NEGATIVE INFECTION; HUMAN; INCIDENCE; PRIORITY JOURNAL; SALMONELLA; SHIGELLA; SHORT SURVEY;

ANTI-BACTERIAL AGENTS; CAMPYLOBACTER COLI; CAMPYLOBACTER JEJUNI; DRUG RESISTANCE, BACTERIAL;

ANIMALIA; BACTERIA (MICROORGANISMS); CAMPYLOBACTER; CAMPYLOBACTER COLI; CAMPYLOBACTER JEJUNI; ESCHERICHIA COLI O157:H-; SALMONELLA; SHIGELLA;

EID: 36348939192     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2007.00935.x     Document Type: Short Survey

References (101)

1. Aarestrup FM Engberg J (2001) Antimicrobial resistance of thermophilic Campylobacter. Vet Res 32 : 311 321.
2. Aarestrup F, Seyfarth A, Emborg H, Pedersen K, Hendriksen R Bager F (2001) Effect of abolishment of the use of antimicrobial agents for growth promotion on occurrence of antimicrobial resistance in faecal enterococci from food animals in Denmark. Antimicrob Agents Chemother 45 : 2054 2059.
3. Adler-Mosca H, Luthy-Hottenstein J, Martinetti Luchini G, Burnens A Altwegg M (1991) Development of resistance to quinolones in five patients with campylobacteriosis treated with norfloxacin or ciprofloxacin. Eur J Clin Microbiol Infect Dis 10 : 953 957.
4. Akiba M, Lin J, Barton Y-W Zhang Q (2006) Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni. J Antimicrob Chemother 57 : 52 60.
5. Alfredson D Korolik V (2005) Isolation and expression of a novel molecular class D β-lactamase, OXA-61, from Campylobacter jejuni. Antimicrob Agents Chemother 49 : 2515 2518.
6. Allos BM (2001) Campylobacter jejuni Infections: update on emerging issues and trends. Clin Infect Dis 32 : 1201 1206.
7. Bachoual R, Ouabdesselam S, Mory F, Lascols C, Soussy CJ Tankovic J (2001) Single or double mutational alterations of gyrA associated with fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli. Microb Drug Resist 7 : 257 261.
8. Bacon DJ, Alm RA, Burr DH, Hu L, Kopecko DJ, Ewing CP, Trust TJ Guerry P (2000) Involvement of a plasmid in virulence of Campylobacter jejuni 81-176. Infect Immun 68 : 4384 4390.
9. Batchelor RA, Pearson BM, Friis LM, Guerry P Wells JM (2004) Nucleotide sequences and comparison of two large conjugative plasmids from different Campylobacter species. Microbiology 150 : 3507 3517.
10. Blumer C, Roche P, Spencer J et al 2003) Australia's notifiable disease status, 2001. Annual report of the National Notifiable Diseases Surveillance System. Commun Dis Intell 27 : 1 78.
11. Cagliero C, Mouline C, Cloeckart A Payot S (2006) Synergy between efflux pump CmeABC and modification in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli. Antimicrob Agents Chemother 50 : 3893 3896.
12. Cao TB Saier MH Jr. (2001) Conjugal type IV macromolecular transfer systems of gram-negative bacteria: organismal distribution, structural constraints and evolutionary conclusions. Microbiology 147 : 3201 3214.
13. Centers for Disease Control and Prevention 2004) Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food: selected sites, United States, 2003. Morb Mortal Weekly Rep 53 : 338 343.
14. Charvalos E, Tselentis Y, Hamzehpour MM, Kohler T Pechere J-C (1995) Evidence for an efflux pump in multidrug-resistant Campylobacter jejuni. Antimicrob Agents Chemother 39 : 2019 2022.
15. Chopra I (1985) Mode of action of the tetracyclines and the nature of bacterial resistance to them. The Tetracyclines (Handbook of Experimental Pharmacology), Vol. 78 Boothe JH Hlavka JJ, eds), pp. 317 392. Springer-Verlag, Berlin, Germany.
16. Chopra I Roberts M (2001) Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev 65 : 232 260.
17. Coker AO, Isokpehi RD, Thomas BN, Amisu KO Obi CL (2002) Human campylobacteriosis in developing countries. Emerg Infect Dis 8 : 237 243.
18. Connell SR, Tracz DM, Nierhaus KH Taylor DE (2003) Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrob Agents Chemother 47 : 3675 3681.
19. Corcoran D, Quinn T, Cotter L Fanning S (2006) An investigation of the molecular mechanisms contributing to high-level erythromycin resistance in Campylobacter. Int J Antimicrob Agents 27 : 40 45.
20. Derbise A, Aubert S El Solh N (1997) Mapping the regions carrying the three contiguous antibiotic resistance genes aadE, sat4, and aphA-3 in the genomes of staphylococci. Antimicrob Agents Chemother 41 : 1024 1032.
21. Doyle D, McDowall KJ, Butler MJ Hunter IS (1991) Characterisation of an oxytetracycline-resistance gene, otrA, of Streptomyces rimosus. Mol Microbiol 5 : 2923 2933.
22. Endtz HPh, Ruijs GJ, van Klingeren B, Jansen WH, van der Reyden T Mouton RP (1991) Quinolone resistance in campylobacter isolated from man and poultry following the introduction of fluoroquinolones in veterinary medicine. J Antimicrob Chemother 27 : 199 208.
23. Ellis-Pegler RB, Hyman LK, Ingram RJ McCarthy M (1995) A placebo controlled evaluation of lomefloxacin in the treatment of bacterial diarrhoea in the community. J Antimicrob Chemother 36 : 259 263.
24. Engberg J, Aarestrup FM, Taylor DE, Gerner-Smidt P Nachamkin I (2001) Quinolone and macrolides resistance in Campylobacter jejuni and Campylobacter coli: resistance mechanisms and trends in human isolates. Emerg Infect Dis 7 : 24 34.
25. Friedman CR, Niemann J, Wegener HC Tauxe RV (2000) Epidemiology of Campylobacter jejuni infections in the United States and other industrialised nations. Campylobacter (Nachampkin I Blaser MJ, eds), pp. 121 138. ASM Press, Washington, DC.
26. Gallay A, Simon F Megraud F (2003) Surveillance of human Campylobacter infections in France. Eur Commun Dis Bull Eurosurveill 8 : 213 217.
27. Gaudreau C Michaud S (2003) Cluster of erythromycin- and ciprofloxacin-resistant Campylobacter jejuni subsp. jejuni from 1999 to 2001 in men who have sex with men, Quebec, Canada. Clin Infect Dis 37 : 131 136.
28. Ge B, McDermott P, White D Meng J (2005) Role of efflux pumps and topoisomerase mutations in fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli. Antimicrob Agents Chemother 49 : 3347 3354.
29. Gerrits MM, De Zoete MR, Arents NL, Kuipers EJ Kusters JG (2002) 16S rRNA mutation-mediated tetracycline resistance in Helicobacter pylori. Antimicrob Agents Chemother 46 : 2996 3000.
30. Gibreel A Skold O (1998) High-level resistance to trimethoprim in clinical isolates of Campylobacter jejuni by acquisition of foreign genes (dfr1 and dfr9) expressing drug-insensitive dihydrofolate reductases. Antimicrob Agents Chemother 42 : 3059 3064.
31. Gibreel A Skold O (2000) An integron cassette carrying dfr1 with 90-bp repeat sequences located on the chromosome of trimethoprim-resistant isolates of Campylobacter jejuni. Microb Drug Resist 6 : 91 98.
32. Gibreel A Taylor DE (2006) Macrolide resistance in Campylobacter jejuni and Campylobacter coli. J Antimicrob Chemother 58 : 243 255.
33. Gibreel A, Sjogren E, Kaijser B, Wretlind B Skold O (1998) Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyrA and parC. Antimicrob Agents Chemother 42 : 3276 3278.
34. Gibreel A, Skold O Taylor DE (2004) Characterization of plasmid-mediated apha-3 kanamycin resistance in Campylobacter jejuni. Microb Drug Resist 10 : 98 105.
35. Gibreel A, Kos VN, Keelan M, Trieber CA, Levesque S, Michaud S Taylor DE (2005) Macrolide resistance in Campylobacter jejuni and Campylobacter coli: molecular mechanism and stability of the resistance phenotype. Antimicrob Agents Chemother 49 : 2753 2759.
36. Griggs DJ, Johnson MM, Frost JA, Humphrey T, Jørgensen F Piddock LJV (2005) Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment. Antimicrob Agents Chemother 49 : 699 707.
37. Hardy DJ, Hensey DM, Beyer JM, Vojtko C, McDonald EJ Fernandes PB (1988) Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides. Antimicrob Agents Chemother 32 : 1710 1719.
38. Hart WS, Heuzenroeder MW Barton MD (2004) Antimicrobial resistance in Campylobacter spp., Escherichia coli and enterococci associated with pigs in Australia. J Vet Med B Infect Dis Vet Public Health 51 : 216 221.
39. Hoge CW, Gambel JM, Srijan A, Pitarangsi C Echeverria P (1998) Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years. Clin Infect Dis 26 : 341 345.
40. Humphrey TJ, Jørgensen F, Frost JA, Wadda H, Domingue G, Elviss NC, Griggs DJ Piddock LJV (2005) Prevalence and subtypes of ciprofloxacin- resistant Campylobacter spp. in commercial poultry flocks before, during, and after treatment with fluoroquinolones. Antimicrob Agents Chemother 49 : 690 698.
41. Huysmans MB Turnidge JD (1997) Disc susceptibility testing for thermophilic campylobacters. Pathology 29 : 209 216.
42. Isenbarger DW, Hoge CW, Srijan A, Pitarangsi C, Vithayasai N, Bodhidatta L, Hickey KW Cam PD (2002) Comparative antibiotic resistance of diarrheal pathogens from Vietnam and Thailand, 1996-1999. Emerg Infect Dis 8 : 175 180.
43. Jacob-Reitsma W, Koenraad P, Bolder N Mulder R (1994) In vitro susceptibility of Campylobacter and Salmonella isolates from broilers to quinolones, ampicillin, tetracycline, and erythromycin. Vet Q 16 : 206 208.
44. Jensen LB Aarestrup FM (2001) Macrolide resistance in Campylobacter coli of animal origin in Denmark. Antimicrob Agents Chemother 45 : 371 372.
45. Jiminez A, Velasquez JB, Rodriguez J, Tinijas A Villa TG (1994) Prevalence of fluoroquinolone resistance in clinical strains of Campylobacter jejuni isolated in Spain. J Antimicrob Chemother 33 : 188 190.
46. Khachatourians GG (1998) Agricultural use of antibiotics and the evolution and transfer of antibiotic-resistant bacteria. CMAJ 159 : 1129 1136.
47. Lachance NC, Gaudreau C, Lamothe F Lariviere LA (1991) Role of the β-lactamase of Campylobacter jejuni in resistance to β-lactam agents. Antimicrob Agents Chemother 35 : 813 818.
48. Lariviere LA, Gaudreau CL Turgeon FF (1986) Susceptibility of clinical isolates of Campylobacter jejuni to twenty-five antimicrobial agents. J Antimicrob Chemother 18 : 681 685.
49. Leclercq R (2002) Mechanisms of resistance macrolides and lincosamides: nature of resistance elements and their clinical implications. Clin Infect Dis 34 : 482 492.
50. Lee MD, Sanchez S, Zimmer M, Umelaalim I, Berrang ME McDermott PF (2002) Class 1 integron-associated tobramycin-gentamicin resistance in Campylobacter jejuni isolated from the broiler chicken house environment. Antimicrob Agents Chemother 46 : 3660 3664.
51. Leipe DD, Wolfe YI, Koonin EV Aravind L (2002) Classification and evolution of P-loop GTPases and related ATPases. J Mol Biol 317 : 41 72.
52. Li CC, Chiu CH, Wu JL, Huang YC Lin TY (1998) Antimicrobial susceptibilities of Campylobacter jejuni and coli by using E-test in Taiwan. Scand J Infect Dis 30 : 39 42.
53. Liebert CA, Hall RM Summers AO (1999) Transposon Tn21, Flagship of the floating genome. Microbiol Mol Biol Rev 63 : 507 522.
54. Lin J, Michel LO Zhang Q (2002) CmeABC functions as a multi-drug efflux system in Campylobacter jejuni. Antimicrob Agents Chemother 46 : 2124 2131.
55. Luber P, Wagner J, Hahn H Bartelt E (2003) Antimicrobial resistance in Campylobacter jejuni and Campylobacter coli strains isolated in 1991 and 2001-2002 from poultry and humans in Berlin, Germany. Antimicrob Agents Chemother 47 : 3825 3830.
56. Lucey B, Crowley D, Moloney P, Cryan B, Daly M, O'Halloran F, Threllfall EJ Fanning S (2000) Integron-like structures in Campylobacter spp. of human and animal origin. Emerg Infect Dis 6 : 50 55.
57. Luo N, Sahin O, Lin J, Michel LO Zhang Q (2003) In vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pump. Antimicrob Agents Chemother 47 : 390 394.
58. McDermott PF, Bodeis SM, English LL, White DG, Walker RD, Zhao S, Simjee S Wagner DD (2002) Ciprofloxacin resistance in Campylobacter jejuni evolves rapidly in chickens treated with fluoroquinolones. J Infect Dis 185 : 837 840.
59. Moore JE, Barton MD, Blair IS et al 2006) The epidemiology of antibiotic resistance in Campylobacter. Microbes Infect 8 : 1955 1966.
60. Nachamkin I Blaser MJ (2000) Campylobacter, 2nd edn. ASM Press, Washington, DC.
61. Nachamkin I, Ung H Li M (2002) Increasing fluoroquinolone resistance in Campylobacter jejuni, Pennsylvania, USA, 1982-2001. Emerg Infect Dis 12 : 1501 1503.
62. Nirdnoy W, Mason CJ Guerry P (2005) Mosaic structure of a multiple-drug-resistant, conjugative plasmid from Campylobacter jejuni. Antimicrob Agents Chemother 49 : 2454 2459.
63. Oberhelman RA Taylor DN (2000) Campylobacter infections in developing countries. Campylobacter, 2nd edn (Nachampkin I Blaser MJ, eds), pp. 139 153. ASM Press, Washington, DC.
64. O'Halloran F, Lucey B, Cryan B, Buckley T Fanning S (2004) Molecular characterisation of class 1 integrons from Irish thermophilic Campylobacter spp. J Antimicrob Chemother 53 : 952 957.
65. Oliva B, Gordon G, McNicholas P, Ellestad G Chopra I (1992) Evidence that tetracycline analogs whose primary target is not the bacterial ribosome cause lysis of Escherichia coli. Antimicrob Agents Chemother 36 : 913 919.
66. Ouellette M, Gerbaud G, Lambert T Courvalin P (1987) Acquisition by a Campylobacter-like strain of apha-1, a kanamycin resistance determinant from members of the family Enterobacteriaceae. Antimicrob Agents Chemother 31 : 1021 1026.
67. Padungton P Kaneene JB (2003) Campylobacter spp. in human, chickens, pigs and their antimicrobial resistance. J Vet Med Sci 65 : 161 170.
68. Parkhill J, Wren BW, Mungall K et al 2000) The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature 403 : 665 668.
69. Partridge RR Hall RM (2003) In34, a complex In5 family class 1 integron containing orf513 and dfrA10. Antimicrob Agents Chemother 47 : 342 349.
70. Payot S, Avrain L, Magras C, Praud K, Cloeckart A Chaslus-Dancla E (2004) Relative contribution of target gene mutation and efflux to fluoroquinolone and erythromycin resistance in French poultry and pig isolates of Campylobacter coli. Int J Antimicrob Agents 23 : 468 472.
71. Payot S, Bolla J-M, Corcoran D, Fanning S, Megraud F Zhang Q (2006) Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter sp. Microbes Infect 8 : 1967 1971.
72. Petruccelli BP, Murphy GS, Sanchez JL, Walz S, DeFraites R, Gelnett J, Haberberger RL, Echeverria P Taylor DN (1992) Treatment of travelers' diarrhea with ciprofloxacin and loperamide. J Infect Dis 165 : 557 560.
73. Piddock LJ, Ricci V, Pumbwe L, Everett MJ Griggs DJ (2003) Fluoroquinolone resistance in Campylobacter species from man and animals: detection of mutations in topoisomerase genes. J Antimicrob Chemother 51 : 19 26.
74. Pratt A Korolik V (2005) Tetracycline resistance of Australian Campylobacter jejuni and Campylobacter coli isolates. J Antimicrob Chemother 55 : 452 460.
75. Pumbwe L Piddock LJV (2002) Identification and molecular characterisation of CmeB, a Campylobacter jejuni multi-drug efflux pump. FEMS Microbiol Lett 206 : 185 189.
76. Pumbwe L, Randall LP, Woodward MJ Piddock LJ (2005) Evidence for multiple antibiotic resistance in Campylobacter jejuni not mediated by CmeB or CmeF. Antimicrob Agents Chemother 49 : 1289 1293.
77. Rasmussen B, Noller HF, Daubresse G, Oliva B, Misulovin Z, Rothstein DM, Ellestad GA, Gluzman Y, Tally FP Chopra I (1991) Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome. Antimicrob Agents Chemother 35 : 2306 2311.
78. Reina J, Ros MJ Serra A (1994) Susceptibilities to 10 antimicrobial agents of 1,220 Campylobacter strains isolated from 1987 to 1993 from faeces of pediatric patients. Antimicrob Agents Chemother 38 : 2917 2920.
79. Ross JL, Eady EA, Cove JH Cunliffe WJ (1998) 16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium. Antimicrob Agents Chemother 42 : 1702 1705.
80. Saenz Y, Zarazaga M, Lantero M, Gastanares M, Bacuero F Torres C (2000) Antibiotic resistance in Campylobacter strains isolated from animals, foods and humans in Spain in 1997-1998. Antimicrob Agents Chemother 44 : 267 271.
81. Sam WIC, Lyons MM Waghorn DJ (1999) Increasing rates of ciprofloxacin resistant Campylobacter. J Clin Pathol 52 : 709 710.
82. Speer BS Salyers AA (1989) Novel aerobic tetracycline resistance gene that chemically modifies tetracycline. J Bacteriol 171 : 148 153.
83. Tajada P, Gomez-Garcez J-L, Alos J-I, Balas D Cogollos R (1996) Antimicrobial susceptibilities of Campylobacter jejuni and Campylobacter coli to 12 β-lactam agents and combinations with β-lactamase inhibitors. Antimicrob Agents Chemother 40 : 1924 1925.
84. Takkinen J, Ammon A, Robstad O, Breuer T The Campylobacter Working Group (2003) European survey on Campylobacter surveillance and diagnosis 2001. Eur Commun Dis Bull Eurosurveill 8 : 207 213.
85. Taylor DE (1986) Plasmid-mediated tetracycline resistance in Campylobacter jejuni: expression in E. coli and identification of homology with streptococcal class M determinant. J Bacteriol 165 : 1037 1039.
86. Taylor DE (1992) Genetics of Campylobacter and Helicobacter. Annu Rev Microbiol 46 : 35 64.
87. Taylor DE Chau A (1996) Tetracycline resistance mediated by ribosomal protection. Antimicrob Agents Chemother 40 : 1 5.
88. Taylor DE Courvalin P (1988) Mechanisms of antibiotic resistance in Campylobacter species. Antimicrob Agents Chemother 32 : 1107 1112.
89. Taylor DE, Sanchez JL, Candler W, Thornton S, McQueen C Escheverria P (1991) Treatment of travelers' diarrhea: ciprofloxacin plus loperamide compared with ciprofloxacin alone. Ann Intern Med 114 : 731 734.
90. Taylor DE, Jerome LJ, Grewal J Chang N (1995) Tet(O), a protein that mediates ribosomal protection to tetracycline, binds, and hydrolyses GTP. Can J Microbiol 41 : 965 970.
91. Tenover FC, Gilbert T O'Hara P (1989) Nucleotide sequence of a novel kanamycin resistance gene, aphA-7, from Campylobacter jejuni and comparison to other kanamycin phosphotransferase genes. Plasmid 22 : 52 58.
92. Trieber CA Taylor DE (2002) Mutations in the 16S ribosomal RNA genes of Helicobacter pylori mediate resistance to tetracycline. J Bacteriol 184 : 2131 2140.
93. Trieber CA, Burkhardt N, Nierhaus KH Taylor DE (1998) Ribosomal protection from tetracycline mediated by Tet(O): Tet(O) interaction with ribosomes is GTP-dependent. Biol Chem 379 : 847 855.
94. Trieu-Cuot P, Gerbaud G, Lambert T Courvalin P (1985) In vivo transfer of genetic information between gram-positive and gram-negative bacteria. EMBO J 4 : 3583 3587.
95. Unicomb L, Ferguson J, Riley TV Collignon P (2003) Fluoroquinolone resistance in Campylobacter absent from isolates, Australia. Emerg Infect Dis 9 : 1482 1483.
96. Unicomb LE, Ferguson J, Stafford RJ, Ashbolt R, Kirk MD, Becker NG, Patel MS, Gilbert GL, Valcanis M Mickan L (2006) Low-level fluoroquinolone resistance among Campylobacter jejuni isolates in Australia. Clin Infect Dis 42 : 1368 1374.
97. Vacher S, Menard A, Bernard E Megraud F (2005) Detection of mutations associated with macrolide resistance in thermophilic Campylobacter spp. by real-time PCR. Microb Drug Resist 11 : 40 47.
98. Van Boven M, Veldman KT, de Jong MC Mevius DJ (2003) Rapid selection of quinolone resistance in Campylobacter jejuni but not in Escherichia coli in individually housed broilers. J Antimicrob Chemother 52 : 719 723.
99. Wang Y, Huang WM Taylor DE (1993) Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterisation of quinolone resistance mutations. Antimicrob Agents Chemother 37 : 457 463.
100. Waters B Davies J (1997) Amino acid varieties in the gyrA subunit of bacteria potentially associated with natural resistance to fluoroquinolone antibiotics. Antimicrob Agents Chemother 41 : 2766 2769.
101. Zilhao R, Papadopoulou B Courvalin P (1988) Occurrence of the Campylobacter resistance gene tetO in Enterococcus and Streptococcus spp. Antimicrob Agents Chemother 32 : 1793 1796.