A novel approach for predicting antidepressant-induced sexual dysfunction in rats

Psychopharmacology

Volumn 195, Issue 4, 2008, Pages 459-467

  Sukoff Rizzo, Stacey J ^a   Schechter, Lee E ^a   Rosenzweig Lipson, Sharon ^a  

^a PFIZER INC   (United States)

Author keywords

Animal model; Antidepressant; Rat; Sexual behavior

Indexed keywords

AMFEBUTAMONE; ANTIDEPRESSANT AGENT; APOMORPHINE; DESIPRAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; FLUOXETINE; SILDENAFIL; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY STIMULATION; CONTROLLED STUDY; ERECTILE DYSFUNCTION; FEMALE; LONG TERM CARE; MALE; MALE SEXUAL DYSFUNCTION; MATING; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; SEXUAL BEHAVIOR; SMELLING; SPRAGUE DAWLEY RAT; TOXICITY TESTING; TREATMENT OUTCOME; VISUAL STIMULATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BUPROPION; DESIPRAMINE; DISEASE MODELS, ANIMAL; DOPAMINE AGONISTS; FLUOXETINE; LONG-TERM CARE; MALE; PENILE ERECTION; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; VASODILATOR AGENTS; YOHIMBINE;

EID: 36348934646     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-007-0924-7     Document Type: Article

References (41)

1. Agmo A, Turi AL, Ellingsen E, Kaspersen H (2004) Preclinical models of sexual desire: conceptual and behavioral analyses. Pharmacol Biochem Behav 78:379-404
2. Ahn GJ, Kahg KK, Kim DS, Ahn BO, Kim WB, Kang SK, Lee BC, Hwang WS (2005) DA-8159 reverses selective serotonin inhibitor-induced erectile dysfunction in rats. Urology 65:202-207
3. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, DC
4. Angulo J, Bischoff E, Gabancho S, Cuevas P, Saenz de Tejada I (2003) Vardenafil reverses erectile dysfunction induced by paroxetine in rats. Int J Impot Res 15:90-93
5. Baldwin DS (2001) Depression and sexual dysfunction. Br Med Bull 57:81-99
6. Balon R (1993) Fluoxetine-induced sexual dysfunction and yohimbine. J Clin Psychiatry 54:161-162
7. Clayton AH, McGarvey EL, Abouesh AI, Pinkerton RC (2001) Substitution of an SSRI with bupropion sustained release following SSRI-induced sexual dysfunction. J Clin Psychiatry 62(3):185-190
8. Clayton AH, Pradko JF, Croft HA, Montano CB, Leadbetter RA, Bolden-Watson C, Bass KI, Donahue RMJ, Jamerson BD, Metz A (2002) Prevalence of sexual dysfunction among newer antidepressants. J Clin Psychiatry 63:357-366
9. Coleman CC, King BR, Bolden-Watson C, Book MJ, Segraves RT, Richard N, Ascher J, Batey S, Jamerson B, Metz A (2001) A placebo-controlled comparison of the effects on sexual functioning of bupropion sustained release and fluoxetine. Clin Ther 23(7):1040-1058
10. Croft H, Settle E Jr, Houser T, Batey SR, Donahue RM, Ascher JA (1999) A placebo-controlled comparison of the antidepressant efficacy and effects on sexual functioning of sustained-release bupropion and sertraline. Clin Ther 21:643-658
11. Ferguson JM (2001) The effects of antidepressants on sexual functioning in depressed patients: a review. J Clin Psychiatry 62(Suppl 3):22-34
12. Frank JL, Hendricks SE, Olson CH (2000) Multiple ejaculations and chronic fluoxetine: effects on male rat copulatory behavior. Pharmacol Biochem Behav 66:337-342
13. Giuliano F, Rampin O (2004) Neural control of erection. Physiol Behav 83:189-201
14. Gregorian RS, Golden KA, Bahce A, Goodman C, Kwong WJ, Khan ZM (2002) Antidepressant-induced sexual dysfunction. Ann Pharmacother 36:1577-1589
15. Harrison WM, Rabkin JG, Ehrhardt AA, Stewart JW, McGrath PJ, Ross D, Quitkin FM (1986) Effects of antidepressant medication on sexual function: A controlled study. J Clin Psychopharmacol 6:144-149
16. Jacobsen FM (1992) Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 53:119-122
17. Joly D, Sanger DJ (1986) The effects of fluoxetine and zimeldine on the behavior of olfactory bulbectomy in rats. Pharmacol Biochem Behav 24:199-204
18. Melis MR, Succu S, Mauri A, Argiolas A (1998) Nitric oxide production is increased in the paraventricular nucleus of the hypothalamus of male rats during non-contact penile erections and copulation. Eur J Neurosci 10:1968-1974
19. Michelson D, Kociban K, Tamura R, Morrison MF (2002) Mirtazapine, yohimbine or olanzapine augmentation therapy for serotonin reuptake-associated female sexual dysfunction: a randomized, placebo controlled trial. J Psychiatr Res 36:147-152
20. Modell JG, Katholi CR, Modell JD, DePalma RL (1997) Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline. Clin Pharmacol Ther 61(4):476-487
21. Montgomery SA, Baldwin DS, Riley A (2002) Antidepressant medications: a review of the evidence for drug-induced sexual dysfunction. J Affect Disord 69:119-140
22. Morales A (2001) Yohimbine in erectile dysfunction: would an orphan drug ever be properly assessed? World J Urol 19:251-255
23. Mos J, Mollet I, Tolboom JTBM, Waldinger MD, Olivier B (1999) A comparison of the effects of different serotonin reuptake blockers on sexual behavior of the male rat. Eur Neuropsychopharmacol 9:123-135
24. Nurnberg HG (2001) Managing treatment-emergent sexual dysfunction associated with serotonergic antidepressants: before and after sildenafil. J Psychiatr Pract 7:92-108
25. Nurnberg HG, Hensley P (2003) Selective phosphodiesterase type-5 inhibitor treatment of serotonergic reuptake inhibitor antidepressant-associated sexual dysfunction. CNS Spectr 8:194-202
26. Nurnberg HG, Hensley PL, Lauriello J, Parker LM, Keith SJ (1999) Sildenafil for women patients with antidepressant-induced sexual dysfunction. Psychiatr Serv 50:1076-1078
27. Nurnberg HG, Hensley P, Gelenberg A, Fava M, Lauriello P, Paine S (2003) Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial. JAMA 289:56-64
28. Redolat R, Vidal J, Gomez MC, Carrasco MC (2005) Effects of acute bupropion administration on locomotor activity in adolescent and adult mice. Behav Pharmacol 16(1):59-62
29. Reneric J, Lucki I (1998) Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test. Exp Clin Psychopharmacol 136:190-197
30. Roose SP (1999) Tolerability and patient compliance. J Clin Psychiatry 60(Suppl 17):14-17
31. Rothschild AJ (2000) New directions in the treatment of antidepressant-induced sexual dysfunction. Clin Ther 22(Suppl A):42-61
32. Sachs BD, Akasofu K, Citron JH, Daniels SB, Natoli JH (1994) Noncontact stimulation from estrous females evokes penile erection in rats. Physiol Behav 55:1073-1079
33. Shen WW, Urosevich Z, Clayton DO (1999) Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors. J Reprod Med 44:535-542
34. Sukoff Rizzo SJ, Schechter LE, Rosenzweig-Lipson S (2005) A novel approach for evaluating antidepressant-induced sexual dysfunction in rats. Soc Neurosci Abstr 559:4
35. Vega Matuszcyk J, Larrson K, Erikkson E (1998) The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in rats. Pharmacol Biochem Behav 60:527-532
36. Waldinger MD, van De Plas A, Pattij T, van Oorschot R, Coolen LM, Veening JG, Olivier B (2002) The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. Psychopharmacology 160:283-289
37. West CHK, Weiss JM (1998) Effects of antidepressant drugs on rats bred for low activity in the swim test. Pharmacol Biochem Behav 61(1):67-79
38. Wilkinson JL, Bevins RA (2007) Bupropion hydrochloride produces conditioned hyperactivity in rats. Physiol Behav 90(5):790-796
39. Worthington JJ, Peters PM (2003) Treatment of antidepressant-induced sexual dysfunction. Drugs Today 39(11):887-896
40. Worthington JJ, Simon NM, Korbly NB, Perlis RH, Pollack MH (2002) Ropinirole for antidepressant-induced sexual dysfunction. Int Clin Psychopharmacol 17:307-310
41. Zajecka J (2001) Strategies for the treatment of antidepressant-related sexual dysfunction. J Clin Psychiatry 62(Suppl 3):35-43