Hb Hekinan in a Taiwanese subject: A G→T substitution at codon 27 of the α1-globin gene abolishes an HaeIII site

Hemoglobin

Volumn 31, Issue 4, 2007, Pages 495-498

  Shih, Hung Chang ^a,b   Shih, Mu Chin ^a   Chang, Yu Chang ^a   Peng, Ching Tien ^a,c   Chang, Tien Jye ^b   Chang, Jan Gowth ^d  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

1 Globin gene; Codon 27; Hb Hekinan; Taiwanese

Indexed keywords

ALPHA GLOBIN; ALPHA1 GLOBIN; ALPHA2 GLOBIN; ASPARTIC ACID; GLUTAMINE; HEMOGLOBIN HEKINAN; HEMOGLOBIN VARIANT; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CAPILLARY ELECTROPHORESIS; CASE REPORT; CODON; DNA ISOLATION; ELECTROPHORESIS; ENZYME ACTIVE SITE; GENE AMPLIFICATION; GENETIC VARIABILITY; HETEROZYGOSITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; RESTRICTION MAPPING; SCHOOL CHILD; TAIWAN;

ALPHA-THALASSEMIA; AMINO ACID SUBSTITUTION; CHILD; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; HEMOGLOBINS, ABNORMAL; HUMANS; MALE; POINT MUTATION; TAIWAN;

EID: 36249028258     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.1080/03630260701590368     Document Type: Article

References (6)

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2. 2] detected in Guyana. Hemoglobin 1989; 13(4):397-402.
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4. Fucharoen S, Changtrakun Y, Ratanasiri T, Fucharoen G, Sanchaisuriya K. Complex interaction of Hb Hekinan [α27(B8)Glu→Asp] and Hb E [β26(B8)Glu→Lys] with a deletional α-thalassemia 1 in a Thai family. Eur J Haematol 2003; 70(5):304-309.
5. Chang J-G, Yang T-Y, Perng L-I, Wang N-M, Peng C-T, Tsai C-H. Hb Siriraj: a G→A substitution at codon 7 of the β-globin chain creates an MboII cutting site. Hemoglobin 1999; 23(2):197-199.
6. Chang J-G, Liu H-C, Shih M-C, Liu S-C, Chan W-L, Tsai F-J. Unstable Hb Perth in a Taiwanese subject: a T→C substitution at codon 32 of the β-globin gene creates an MspI site. Hemoglobin 2002; 26(1):91-94.