Hyperplastic polyps and sessile serrated 'adenomas' of the colon and rectum display gastric pyloric differentiation

Histochemistry and Cell Biology

Volumn 128, Issue 5, 2007, Pages 445-455

  Mochizuka, Akiyoshi ^a   Uehara, Takeshi ^b   Nakamura, Takamichi ^a   Kobayashi, Yukihiro ^b   Ota, Hiroyoshi ^c  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY HOSPITAL   (Japan)

^c SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Homeodomain protein; Hyperplastic polyp; Mucin core protein; Serrated adenoma; TFF

Indexed keywords

HOMEODOMAIN PROTEIN; MUCIN 5AC; MUCIN 6; TREFOIL PEPTIDE;

ARTICLE; CELL DIFFERENTIATION; COLON POLYP; COLORECTAL ADENOMA; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM POLYP; UPREGULATION;

ADENOMA; CELL DIFFERENTIATION; COLONIC NEOPLASMS; COLONIC POLYPS; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; INTESTINAL POLYPS; MUCINS; PYLORUS; RECTAL NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 36248986650     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-007-0326-2     Document Type: Article

References (48)

1. Arakura N, Hayama M, Honda T, Matsuzawa K, Akamatsu T, Ota H (2001) Histone H3 mRNA in situ hybridization for identifying proliferating cells in human pancreas, with special reference to the ductal system. Histochem J 33:183-191
2. Arthur JF (1968) Structure and significance of metaplastic nodules in the rectal mucosa. J Clin Pathol 21:735-743
3. Bai YQ, Yamamoto H, Akiyama Y, Tanaka H, Takizawa T, Koike M, Kenji Yagi O, Saitoh K, Takeshita K, Iwai T, Yuasa Y (2002) Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett 176:47-55
4. Beck F, Chawengsaksophak K, Waring P, Playford RJ, Furness JB (1999) Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice. Proc Natl Acad Sci USA 96:7318-7323
5. Biemer-Huttmann AE, Walsh MD, McGuckin MA, Ajioka Y, Watanabe H, Leggett BA, Jass JR (1999) Immunohistochemical staining patterns of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum. J Histochem Cytochem 47:1039-1048
6. Biemer-Huttmann AE, Walsh MD, McGuckin MA, Simms LA, Young J, Leggett BA, Jass JR (2000) Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clin Cancer Res 6:1909-1916
7. Buisine MP, Devisme L, Maunoury V, Deschodt E, Gosselin B, Copin MC, Aubert JP, Porchet N (2000a) Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands. I. Stomach. A relationship to gastric carcinoma. J Histochem Cytochem 48:1657-1666
8. Buisine MP, Devisme L, Degand P, Dieu MC, Gosselin B, Copin MC, Aubert JP, Porchet N (2000b) Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands. II. Duodenum and liver, gallbladder, and pancreas. J Histochem Cytochem 48:1667-1676
9. Eda A, Osawa H, Yanaka I, Satoh K, Mutoh H, Kihira K, Sugano K (2002) Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J Gastroenterol 37:94-100
10. Faller G, Dimmler A, Rau T, Spaderna S, Hlubek F, Jung A, Kirchner T, Brabletz T (2004) Evidence for acid-induced loss of Cdx2 expression in duodenal gastric metaplasia. J Pathol 203:904-908
11. Fujimori Y, Akamatsu T, Ota H, Katsuyama T (1995) Proliferative markers in gastric carcinoma and organoid differentiation. Hum Pathol 26:725-734
12. Gannon M, Gamer LW, Wright CV (2001) Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev Biol 238:185-201
13. Glatz K, Pritt B, Glatz D, Hartmann A, O'Brien MJ, Blaszyk H (2007) A multinational, internet-based assessment of observer variability in the diagnosis of serrated colorectal polyps. Am J Clin Pathol 127:938-945
14. Goldstein NS, Bhanot P, Odish E, Hunter S (2003) Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas. Am J Clin Pathol 119:778-796
15. Hamilton SR, Volgelstein B, Kudo S, Riboil E, Nakamura S, Hainaut P, Rubio CA, Sobin LH, Fogt F, Winawer SJ, Goldgar DE, Jass JR (eds) (2000) Carcinoma of the colon and rectum. IARC Press, Lyon, pp 105-119
16. Hanby AM, Poulsom R, Singh S, Elia G, Jeffery RE, Wright NA (1993) Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. Gastroenterology 105:1110-1116
17. Hawkins NJ, Ward RL (2001) Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst 93:1307-1313
18. Higuchi T, Sugihara K, Jass JR (2005) Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 47:32-40
19. Hirono H, Ajioka Y, Watanabe H, Baba Y, Tozawa E, Nishikura K, Mukai G, Honma T, Aoyagi Y (2004) Bidirectional gastric differentiation in cellular mucin phenotype (foveolar and pyloric) in serrated adenoma and hyperplastic polyp of the colorectum. Pathol Int 54:401-407
20. Hoffmann W (2004) Trefoil factor family (TFF) peptides: regulators of mucosal regeneration and repair, and more. Peptides 25:727-730
21. Honda T, Ota H, Ishii K, Nakamura N, Kubo K, Katsuyama T (1998) Mucinous bronchioloalveolar carcinoma with organoid differentiation simulating the pyloric mucosa of the stomach: clinicopathologic, histochemical, and immunohistochemical analysis. Am J Clin Pathol 109:423-430
22. Iino H, Jass JR, Simms LA, Young J, Leggett B, Ajioka Y, Watanabe H (1999) DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol 52:5-9
23. Inada K, Nakanishi H, Fujimitsu Y, Shimizu N, Ichinose M, Miki K, Nakamura S, Tatematsu M (1997) Gastric and intestinal mixed and solely intestinal types of intestinal metaplasia in the human stomach. Pathol Int 47:831-841
24. Ishihara K, Kurihara M, Goso Y, Urata T, Ota H, Katsuyama T, Hotta K (1996) Peripheral alpha-linked N-acetylglucosamine on the carbohydrate moiety of mucin derived from mammalian gastric gland mucous cells: epitope recognized by a newly characterized monoclonal antibody. Biochem J 318:409-416
25. Ishii K, Hosaka N, Toki T, Momose M, Hidaka E, Tsuchiya S, Katsuyama T (1998) A new view of the so-called adenoma malignum of the uterine cervix. Virchows Arch 432:315-322
26. Jass JR, Whitehall VL, Young J, Leggett BA (2002) Emerging concepts in colorectal neoplasia. Gastroenterology 123:862-876
27. Kambara T, Simms LA, Whitehall VL, Spring KJ, Wynter CV, Walsh MD, Barker MA, Arnold S, McGivern A, Matsubara N, Tanaka N, Higuchi T, Young J, Jass JR, Leggett BA (2004) BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 53:1137-1144
28. Katsuyama T, Spicer SS (1978) Histochemical differentiation of complex carbohydrates with variants of the concanavalin A-horseradish peroxidase method. J Histochem Cytochem 26:233-250
29. Koike M, Inada K, Nakanishi H, Matsuura A, Nakamura S, Tatematsu M (2003) Cellular differentiation status of epithelial polyps of the colorectum: the gastric foveolar cell-type in hyperplastic polyps. Histopathology 42:357-364
30. Kushima R, Borchard F, Hattori T (1997) A new aspect of gastric metaplasia in Crohn's disease: bidirectional (foveolar and pyloric) differentiation in so-called 'pyloric metaplasia' in the ileum. Pathol Int 47:416-419
31. Longacre TA, Fenoglio-Preiser CM (1990) Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol 14:524-537
32. Matsuzawa K, Akamatsu T, Katsuyama T (1992) Mucin histochemistry of pancreatic duct cell carcinoma, with special reference to organoid differentiation simulating gastric pyloric mucosa. Hum Pathol 23:925-933
33. Moniaux N, Escande F, Porchet N, Aubert JP, Batra SK (2001) Structural organization and classification of the human mucin genes. Front Biosci 6:D1192-1206
34. Nakajima K, Ota H, Zhang MX, Sano K, Honda T, Ishii K, Nakayama J (2003) Expression of gastric gland mucous cell-type mucin in normal and neoplastic human tissues. J Histochem Cytochem 51:1689-1698
35. Nomura S, Settle SH, Leys CM, Means AL, Peek RM Jr, Leach SD, Wright CV, Coffey RJ, Goldenring JR (2005) Evidence for repatterning of the gastric fundic epithelium associated with Menetrier's disease and TGFalpha overexpression. Gastroenterology 128:1292-1305
36. O'Brien MJ, Yang S, Mack C, Xu H, Huang CS, Mulcahy E, Amorosino M, Farraye FA (2006) Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. Am J Surg Pathol 30:1491-1501
37. Ota H, Hayama M, Nakayama J, Hidaka H, Honda T, Ishii K, Fukushima M, Uehara T, Kurihara M, Ishihara K, Hotta K, Katsuyama T (2001) Cell lineage specificity of newly raised monoclonal antibodies against gastric mucins in normal, metaplastic, and neoplastic human tissues and their application to pathology diagnosis. Am J Clin Pathol 115:69-79
38. Parfitt JR, Driman DK (2007) Survivin and hedgehog protein expression in serrated colorectal polyps: an immunohistochemical study. Hum Pathol 38:710-717
39. Podolsky DK, Lynch-Devaney K, Stow JL, Oates P, Murgue B, DeBeaumont M, Sands BE, Mahida YR (1993) Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion. J Biol Chem 268:6694-6702
40. Ruchaud-Sparagano MH, Westley BR, May FE (2004) The trefoil protein TFF1 is bound to MUC5AC in human gastric mucosa. Cell Mol Life Sci 61:1946-1954
41. Sakai H, Eishi Y, Li XL, Akiyama Y, Miyake S, Takizawa T, Konishi N, Tatematsu M, Koike M, Yuasa Y (2004) PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas. Gut 53:323-330
42. Shiozawa T, Tsukahara Y, Ishii K, Ota H, Nakayama J, Katsuyama T (1992) Histochemical demonstration of gastrointestinal mucins in ovarian mucinous cystadenoma. Acta Pathol Jpn 42:104-110
43. Snover DC, Jass JR, Fenoglio-Preiser C, Batts KP (2005) Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept. Am J Clin Pathol 124:380-391
44. Stoffers DA, Heller RS, Miller CP, Habener JF (1999) Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology 140:5374-5381
45. Tatematsu M, Tsukamoto T, Inada K (2003) Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia. Cancer Sci 94:135-141
46. Terris B, Dubois S, Buisine MP, Sauvanet A, Ruszniewski P, Aubert JP, Porchet N, Couvelard A, Degott C, Flejou JF (2002) Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions. J Pathol 197:632-637
47. Torlakovic E, Skovlund E, Snover DC, Torlakovic G, Nesland JM (2003) Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol 27:65-81
48. Yao T, Kouzuki T, Kajiwara M, Matsui N, Oya M, Tsuneyoshi M (1999) 'Serrated' adenoma of the colorectum, with reference to its gastric differentiation and its malignant potential. J Pathol 187:511-517