The effects of exercise training on arterial baroreflex sensitivity in neurally mediated syncope patients

European Heart Journal

Volumn 28, Issue 22, 2007, Pages 2749-2755

  Gardenghi, Giulliano ^a   Rondon, Maria Urbana P B ^a   Braga, Ana Maria F W ^a   Scanavacca, Mauricio I ^a   Negrão, Carlos Eduardo ^a   Sosa, Eduardo ^a   Hachul, Denise Tessariol ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Autonomic nervous system; Baroreceptors; Exercise; Syncope

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; FLUDROCORTISONE; FLUOXETINE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; SERTRALINE;

ADULT; ARTERY; ARTICLE; CARDIOPULMONARY EXERCISE TEST; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; EXERCISE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVE CONDUCTION; NEUROGRAPHY; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SYMPATHETIC NERVE; SYMPATHETIC REFLEX; SYNCOPE; TRAINING; VAGUS REFLEX;

ADOLESCENT; ADULT; BAROREFLEX; EXERCISE TEST; EXERCISE THERAPY; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; RECURRENCE; SYMPATHETIC NERVOUS SYSTEM; SYNCOPE, VASOVAGAL; VAGUS NERVE;

EID: 36248981762     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehm208     Document Type: Article

References (34)

1. Béchir M, Binggeli C, Corti R, Chenevard R, Spieker L, Ruschitzka F, Lüscher TF, Noll G. Dysfunctional baroreflex regulation of sympathetic nervous activity in patients with vasovagal syncope. Circulation 2003;107:1620-1625.
2. Wijeysundera DN, Butler GC, And S, Pollard MJ, Picton P, Floras JS. Attenuated cardiac baroreflex in men with presyncope evoked by lower body negative pressure. Clin Sci 2001;100:303-309.
3. Thomson HL, Lele SS, Atherton JJ, Wright KN, Stafford W, Frenneaux MP. Abnormal forearm responses during leg exercise in patients with vasovagal syncope. Circulation 1995;92:2204-2209.
4. Gulli G, Cooper VL, Claydon VE, Hainsworth R. Prolonged latency in the baroreflex mediated vascular response in subjects with postural related syncope. Clin Auton Res 2005;15:207-212.
5. 2max. Aviat Space Environ Med 1984;55:702-708.
6. Mayerson HS, Burch GE. Relationships of tissue (subcutaneous and in transmuscular) and venous pressures to syncope induced in man by gravity. Am J Physiol 1940;128:258-269.
7. Mtinangi BL, Hainsworth R. Increased orthostatic tolerance following moderate exercise training in patients with unexplained syncope. Heart 1998;80:596-600.
8. Mtinangi BL, Hainsworth R. Effect of moderate exercise training on plasma volume, baroreceptor sensitivity and orthostatic tolerance in healthy subjects. Exp Physiol 1999;84:121-130.
9. Carrol JF, Wood CE, Pollock MI, Graves JE, Convertino VA, Lowenthal DT. Hormonal responses in elders experiencing pre-syncopal symptoms during head-up tilt before and after exercise training. J Gerontol A Biol Sci Med Sci 1995;50:M324-M329.
10. Krieger EM, Brum PC, Negrão CE. Role of arterial function on cardiovascular adjustments to acute and chronic dynamic exercise. Biol Res 1998;31:273-279.
11. Brum PC, da Silva GJJ, Moreira ED, Ida F, Negrão CE, Krieger EM. Exercise training increases baroreceptor gain activity in normal and hypertensive rats. Hypertension 2000;36:1018-1022.
12. Silva GJJ, Brum PC, Negrão CE, Krieger EM. Acute and chronic effects on baroreflexes in spontaneously hypertensive rats. Hypertension 1997;30:714-719.
13. Liu JL, Irvine S, Reid IA, Patel KP, Zucker IH. Chronic exercise reduces sympathetic nerve activity in rabbits with pacing-induced heart failure. Circulation 2000;102:1854-1862.
14. Delius W, Hagbarth KE, Hongell A, Wallin BG. Maneuvers affecting sympathetic outflow in human muscle nerves. Acta Physiol Scand 1972;84:82-94.
15. Valbo AB, Hagbarth KE, Torebjork HE, Wallin BG. Somatosensory, proprioceptive and sympathetic activity in human peripheral nerves. Physiol Rev 1979;59:919-957.
16. Mosqueda-Garcia R, Furlan R, Fernandez-Violante R, Desai T, Snell M, Jarai Z, Ananthram V, Robertson RM, Robertson D. Sympathetic and baroreflex function in neurally mediated syncope evoked by tilt. J Clin Invest 1997;99:2735-2744.
17. Fagius J, Wallin BG. Long-term variability and reproducibility of human muscle nerve activity at rest, as reassessed after a decade. Clin Auton Res 1993;3:201-205.
18. Smyth HS, Sleight P, Pickering GW. Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity. Circ Res 1969;24:109-121.
19. Cohen-Solal A. Cardiopulmonary exercise testing in chronic heart failure. In: Wasserman K, ed. Exercise Gas Exchange in Heart Disease. 1st ed. Armonk, NY: Futura Publishing Company; 1996. p17-38.
20. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting the anaerobic threshold by gas exchange. J Appl Physiol 1986;60:2020- 2027.
21. Wasserman K, Whipp BJ, Koyal SN, Beaver WL. Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol 1973;33:236-243.
22. Wasserman K, Hansen JE, Sue DY. Principles of exercise testing and interpretation. In: Wasserman K, Hansen JE, Sue DY, Whipp BJ, ed. Measurements of the Physiological Response to Exercise. Philadelphia, PA: Lea & Febiger; 1987. p27-46.
23. Roveda F, Middlekauff HR, Rondon MUPB, Reis SF, Souza M, Nastari L, Barreto ACP, Krieger EM, Negrão CE. The effects of exercise training on sympathetic neural activation in advanced heart failure. JACC 2003;42:854-860.
24. Keteyan SJ, Levine AB, Brawner CA, Kataoka T, Rogers FJ, Schairer JR, Stein PD, Levine TB, Goldstein S. Exercise training in patients with heart failure: a randomized controlled trial. Ann Intern Med 1996;124:1051-1057.
25. Kilavouri K, Toivonen L, Naveri H, Leinonen H. Reversal of autonomic derangement's by physical training in chronic heart failure assessed by heart rate variability. Eur Heart J 1995;16:490-505.
26. Hachul D, Scanavacca M, Sosa E. Does a role exist for tilting-guided therapy in the management of neurocardiogenic syncope? Arq Bras Cardiol 2002;78:167-171.
27. Kuniyoshi FHS, Trombetta IC, Batalha LT, Rondon MUPB, Laterza MC, Gowdak MMG, Barreto ACP, Halpern A, Vilares SMF, Lima EG, Negrão CE. Abnormal neurovascular control during sympathoexcitation in obesity. Obes Res 2003;11:1411-1419.
28. Furlan R, Jacob G, Snell M, Robertson D, Porta A, Harris P, Mosqueda-Garcia R. Chronic orthostatic intolerance: a disorder with discordant cardiac and vascular sympathetic control. Circulation 1998;98:2154-2159.
29. Morillo CA, Eckberg DL, Ellenbogen LA, Beightol LA, Hoag JB, Tahvanainen KUO, Kuusela TA, Diedrich AM. Vagal and sympathetic mechanisms in patients with orthostatic vasovagal syncope. Circulation 1997;96:2509-2513.
30. De Angelis K, Wichi RB, Jesus WRA, Moreira E, Morris M, Krieger EM, Irigoyen MC. Exercise training changes autonomic cardiovascular balance in mice. J Appl Physiol 2004;96:2174-2178.
31. Wieling W, van Lieshout JJ. The fainting risk. Clin Auton Res 2002;12:242-249.
32. van Lieshout JJ. Exercise training and orthostatic intolerance: a paradox? J Physiol 2003;551:401. Published online ahead of print July 1, 2003.
33. Numata T, Abe H, Nagatomo T, Sonoda S, Kohshi K, Nakashima Y. Successful treatment of malignant neurocardiogenic syncope with repeated tilt training program. Jpn Circ J 2000;64:406-409.
34. Reybrouck T, Heidbüchel H, Van De Werf F, Ector H. Tilt training: a treatment for malignant and recurrent neurocardiogenic syncope. PACE 2000;23:493-498.