Hyperactivity and novelty-induced hyperreactivity in mice lacking Rac3

Behavioural Brain Research

Volumn 186, Issue 2, 2008, Pages 246-255

  Corbetta, Sara ^a   D'Adamo, Patrizia ^b   Gualdoni, Sara ^a   Braschi, Chiara ^d   Berardi, Nicoletta ^c,d   de Curtis, Ivan ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b DULBECCO TELETHON INSTITUTE   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d CNR   (Italy)

Author keywords

Exploration tests; GTPases; Hyperactivity; Knockout; Rac3; Rho proteins; Water maze task

Indexed keywords

PROTEIN DERIVATIVE; RAC3 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEVELOPMENT; CONTRAST SENSITIVITY; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; HYPERACTIVITY; KNOCKOUT MOUSE; MAZE TEST; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPATIAL MEMORY; TASK PERFORMANCE; VISUAL ACUITY;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ANTIBODIES; BEHAVIOR, ANIMAL; CONTRAST SENSITIVITY; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYPERKINESIS; MAZE LEARNING; MICE; MICE, KNOCKOUT; PHOTIC STIMULATION; RAC GTP-BINDING PROTEINS; TIME FACTORS; VIDEO RECORDING; VISUAL ACUITY;

EID: 36248980916     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2007.08.019     Document Type: Article

References (28)

1. Abo A., Pick E., Hall A., Totty N., Teahan C.G., and Segal A.W. Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature 353 (1991) 668-670
2. Balschun D., Wolfer D.P., Gass P., Mantamadiotis T., Welzl H., Schutz G., et al. Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory?. J Neurosci 23 (2003) 6304-6314
3. Bolis A., Corbetta S., Cioce A., and de Curtis I. Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation. Eur J Neurosci 18 (2003) 2417-2424
4. Cancedda L., Putignano E., Sale A., Viegi A., Berardi N., and Maffei L. Acceleration of visual system development by environmental enrichment. J Neurosci 24 (2004) 4840-4848
5. Cho Y.J., Zhang B., Kaartinen V., Haataja L., de Curtis I., Groffen J., et al. Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia. Mol Cell Biol 25 (2005) 5777-5785
6. Corbetta S., Gualdoni S., Albertinazzi C., Paris S., Croci L., Consalez G.G., et al. Generation and characterization of Rac3 knockout mice. Mol Cell Biol 25 (2005) 5763-5776
7. de Curtis I. Functions of Rac GTPases during neuronal development. Dev Neurosci 2008, in press.
8. Diana G., Valentini G., Travaglione S., Falzano L., Pieri M., Zona C., et al. Enhancement of learning and memory after activation of cerebral Rho GTPases. Proc Natl Acad Sci USA 104 (2007) 636-641
9. Didsbury J., Weber R.F., Bokoch G.M., Evans T., and Snyderman R. Rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem 264 (1989) 16378-16382
10. Gerlai R., Pisacane P., and Erickson S. Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks. Behav Brain Res 109 (2000) 219-227
11. Gualdoni S., Albertinazzi C., Corbetta S., Valtorta F., and de Curtis I. Normal levels of Rac1 are essential for dendritic, but not axonal development in hippocampal neurons. Biol Cell 99 (2007) 455-464
12. Hall A. Rho GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
13. Hayashi M.L., Choi S.Y., Rao B.S., Jung H.Y., Lee H.K., Zhang D., et al. Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice. Neuron 42 (2004) 773-787
14. Knaus U.G., Heyworth P.G., Evans T., Curnutte J.T., and Bokoch G.M. Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 254 (1991) 1512-1515
15. Madani R., Kozlov S., Akhmedov A., Cinelli P., Kinter J., Lipp H.P., et al. Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin. Mol Cell Neurosci 23 (2003) 473-494
16. Malosio M.L., Gilardelli D., Paris S., Albertinazzi C., and de Curtis I. Differential expression of distinct members of the Rho family of GTP-binding proteins during neuronal development: identification of Rac1B, a new neural-specific member of the family. J Neurosci 17 (1997) 6717-6728
17. Meng J., Meng Y., Hanna A., Janus C., and Jia Z. Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci 25 (2005) 6641-6650
18. Meng Y., Zhang Y., Tregoubov V., Janus C., Cruz L., Jackson M., et al. Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron 35 (2002) 121-133
19. Moll J., Sansig G., Fattori E., and van der Putten H. The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene 6 (1991) 863-866
20. Olson M.F., Ashworth A., and Hall A. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269 (1995) 1270-1272
21. Prusky G.T., West P.W., and Douglas R.M. Behavioral assessment of visual acuity in mice and rats. Vision Res 40 (2000) 2201-2209
22. Ridley A.J., Paterson H.F., Johnston C.L., Diekmann D., and Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70 (1992) 401-410
23. Sananbenesi F., Fischer A., Wang X., Schrick C., Neve R., Radulovic J., et al. A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nat Neurosci 10 (2007) 1012-1019
24. Shirsat N.V., Pignolo R.J., Kreider B.L., and Rovera G. A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells. Oncogene 5 (1990) 769-772
25. Soderling S.H., Langeberg L.K., Soderling J.A., Davee S.M., Simerly R., Raber J., et al. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci USA 100 (2003) 1723-1728
26. Sugihara K., Nakatsuji N., Nakamura K., Nakao K., Hashimoto R., Otani H., et al. Rac1 is required for the formation of three germ layers during gastrulation. Oncogene 17 (1998) 3427-3433
27. van Galen E.J., and Ramakers G.J. Rho proteins, mental retardation and the neurobiological basis of intelligence. Prog Brain Res 147 (2002) 295-317
28. Wolfer D.P., and Lipp H.P. A new computer program for detailed off-line analysis of swimming navigation in the Morris water maze. J Neurosci Methods 41 (1992) 65-74