Oropharyngeal aspiration of ricin as a lung challenge model for evaluation of the therapeutic index of antibodies against ricin A-chain for post-exposure treatment

Experimental Lung Research

Volumn 33, Issue 8-9, 2007, Pages 459-481

  Pratt, Timothy S ^a   Pincus, Seth H ^b   Hale, Martha L ^c   Moreira, Andre L ^d   Roy, Chad J ^c   Tchou Wong, Kam Meng ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Lung aspiration; Passive antibody; Post exposure treatment; Ricin

Indexed keywords

RICIN A; RICIN ANTIBODY;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASPIRATION; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; EVALUATION; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; IN VIVO STUDY; LETHALITY; LUNG; LUNG ASPIRATION; LUNG TOXICITY; MALE; MOUSE; NONHUMAN; OROPHARYNX; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; PROVOCATION TEST; SURVIVAL;

ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL LINE; CELL SURVIVAL; HUMANS; INFLAMMATION; LUNG; MALE; MICE; MICE, INBRED BALB C; OROPHARYNX; PULMONARY EDEMA; RICIN;

EID: 36248979166     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.1080/01902140701731805     Document Type: Article

References (42)

1. Franz DR, Jaax NK: Medical aspects of chemical and biological warfare in textbook of military medicine, part one: Ricin toxin. In: Zajtchuk R, Bellamy RF, eds. U.S. Army Office of the Surgeon General, USA, Dept. of the Army; 1997:631-642.
2. Lord JM, Robert, LM, Robertus JD: Ricin: structure, mode of action and some current applications. FASEB J. 1994;8:201-208.
3. Olsnes S, Phil A: Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis. Biochem. 1973;12:3121-3126.
4. Olsnes S, Phil A: Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis. Biochem. 1974;12:3121-3126.
5. Lord JM, Deeks E, Marsden CJ, Moore K, Pateman C, Smith DC, Spooner RA, Watson P, Roberts LM: Retrograde transport of toxins across the endoplasmic reticulum membrance. Biochem Society Trans. 2003;31:1260-1262.
6. Endo Y, Tsurugi K: RNA N-glycosidase activity of ricin A-chain. J Biol Chem. 1987;262:8128-8130.
7. Endo Y, Tsurugi K: The RNA N-glycosidase activity of ricin A-chain. The characterization of the enzymatic activity of ricin A-chain with ribosomes and rRNA. J Biol Chem. 1988;263:8735-8739.
8. Wool IG, Gluck A, Endo Y: Ribotoxin recognition of ribosomal RNA and a proposal for the mechanism of translocation. Trends Biochem Sci. 1992;17:266-269.
9. Vogel P, Rivera VR, Pitt ML, Poli MA: Comparison of the pulmonary distribution and efficacy of antibodies given to mice by intratracheal instillation or aerosol inhalation. Lab anim Sci. 1996;46:516-523.
10. Roy CJ, Hale M, Hartings JM, Pitt L, Duniho S: Impact of inhalation exposure modality and particle size on the respiratory deposition of ricin in BALB/c mice. Inhal Toxicol. 2003;15:619-638.
11. Doebler JA, Wiltshire ND, Mayer TW, Estep JE, Moeller RB, Traub RK, Broomfield CA, Calamaio CA, Thompson WL, Pitt ML: The distribution of [125I]ricin in mice following aerosol inhalation exposure. Toxicology. 1995;98:137-149.
12. Audi J, Belson M, Patel M, Schier J, Osterloh J: Ricin poisoning: a comprehensive review. JAMA 2005;294:2342-2351.
13. Brown RF, White DE: Ultrastructure of rat lung following inhaltion of ricin aerosol. Int J Exp Pathol. 1997;78:267-276.
14. Korcheva V, Wong J, Lindauer M, Jacoby DB, Iordanov MS, Magun B: Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages. Mol Immunol, 2007;44(10):2761-2771.
15. Higuchi S, Tamura T, Oda T: Cross-talk between the pathways leading to the induction of apoptosis and the secretion of tumor necrosis factor-alpha in ricin-treated RAW 264.7 cells. J Biochem. 2003;134:927-933.
16. Korcheva V, Wong J, Corless C Iordanov M, Magun B: Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and p38 MAPK and provides a mouse model of hemolytic uremic syndrome. Am J Pathol. 2005;166:323-339.
17. Hughes JN, Lindsay CD, Griffiths, GD: Morphology of ricin and abrin exposed endothelial cells is consistent with apoptotic cell death. Hum Expt Toxicol. 1996;15;443-451.
18. Soler-Rodriguez A, Ghetie M, Oppenhiemer-Marks N, Uhr JW, Vitetta ES: Ricin A-chain and immunotoxin rapidly damage human endothelial cells: implications for vascular leak syndrome. Exp Cell Res. 1993;206:227-234.
19. Pappeneheimer AM, Uchida T, Harper AA: An immunological study of the diphtheria toxin molecule. Immunochemistry. 1972;9:891-906.
20. Colombatti M, Johnson VG, Skopick HA, Fendley B, Lewis MS, Youle RJ: Identification and characterization of a monoclonal antibody recognizing a galactose-binding domain of the toxin ricin. J Immunol. 1987;38:3339-3344.
21. Lemley PV, Amanatides P, Wright DC: Identification and characterization of a monoclonal antibody that neutralizes ricin toxicity in vitro and in vivo. Hybridoma. 1994;13:417-421.
22. Poli MA, Rivera VR, Pitt ML, Vogel P: Aerosolized specific antibody protects mice from lung injury associated with aerosolized ricin exposure. Toxicon. 1996;34:1037-1044.
23. Hewetson JF, Rivera VR, Creasia DA, Lemley PV, Rippy MK, Poli MA: Protection of mice from inhaled ricin by vaccination with ricin or by passive treatment with heterologous antibody. Vaccine. 1993;11:743-746.
24. Hastings R, Grady M, Sakuma T, Matthay M: Clearance of different-sized proteins from the alveolar spaces of humans and rabbits. J Appl Physiol. 1992;71:1310-1316.
25. Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ: Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation. Exp Lung Res. 2006;32:181-199.
26. Foster WM, Walters DM, Longphre M, Macri K, Miller LM: Methodology for the measurement of mucociliary function in the mouse by scintigraphy. J Appl Physiol. 2001;90:1111-1117.
27. Rao GV, Tinkle S, Weissman DN, Antonini JM, Kashon ML., Salmen R, Battelli LA, Willard PA, Hoover MD, Hubbes AF: Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx. J Toxicol Environ Health A. 2003;66:1441-1452.
28. Maddaloni M, Cooke C, Wilkinson R, Stout AV, Eng L, Pincus SH: Immunological characteristics associated with the protective efficacy of antibodies to ricin. J Immunol. 2004;172:6221-6228.
29. Shi SR, Key ME, Kalra KL: Antigen Retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem. 1991;39:741-748.
30. Pincus SH, Eng L, Cooke CL, Maddaloni M: Identification of hypoglycemia in mice as a surrogate marker of ricin toxicosis. Compar Med. 2002;52:530-533.
31. Muldoon DF, Bagchi D, Hassoun EA, Stohs SJ: The modulating effects of tumor necrosis factor alpha antibody on ricin-induced oxidative stress in mice. J Biochem Toxicol. 1994;9:311-318.
32. Gonzalez TV, Farrant SA, Mantis NJ: Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway. Mol Immunol. 2006;43:1920-1923.
33. Fu XJ, Iijima K, Nozu K Hamahira K, Tanaka R, Oda T, Yoshikawa N, Matsuo M: Role of p38 MAP kinase pathway in a toxin-induced model of hemolytic uremic syndrome. Pediatr Nephrol. 2004;19:844-852.
34. Cook DL, David J, Griffiths GD: Retrospective identification of ricin in animal tissues following administration by pulmonary and oral routes. Toxicol. 2006;223:61-70.
35. Casadevall A: Passive antibody administration (Immediate immunity) as a specific defense against biological weapons. Emerg Infect Dis. 2002;8:833-841.
36. McGuinness CR, Mantis NJ: Characterization of a novel high-affinity monoclonal immunoglobulin G antibody against the ricin B subunit. Infect Immunity. 2006;74:3463-3470.
37. Lebeda FJ, Olson MA: Prediction of a conserved, neutralizing epitope in ribosome-inactivating proteins. Int J Biol Macromolecules. 1999;24:19-26.
38. Kageyama A, Kusano I, Tamura T, Oda T, Muramatsu T: Comparison of the apoptosis-inducing abilities of various protein synthesis inhibitors in U937 cells. Biosci Biotechnol Biochem. 2002;66:835-839.
39. Williams JM, Lea N, Lord JM, Roberts LM, Milford DV, Taylor CM: Comparison of ribosome-inactivating proteins in the induction of apoptosis. Toxicol Lett. 1997;91:121-127.
40. Hassoun E, Wang X: Ricin-induced toxicity in the macrophage J744A.1 cells: the role of TNF-alpha and the modulation effects of TNF-alpha polyclonal antibody. J Biochem Mol Toxicol. 2000;14:95-101.
41. Lord MJ, Jolliffe NA, Marsden CJ, Pateman CS, Smith DC, Spooner RA, Watson PD, Roberts LM: Ricin. Mechanisms of cytotoxicity. Toxicol Rev. 2003;22:53-64.
42. Griffiths GD, Lindsay CD, Allenby AC, Bailey SC, Scawin JW, Rice P, Upshall DG: Protection against inhalation toxicity of ricin and abrin by immunization. Hum Exp Toxicol. 1995;14:155-164.