Selective targeting of adenoviral vectors to neural precursor cells in the hippocampus of adult mice: New prospects for in situ gene therapy

Stem Cells

Volumn 25, Issue 11, 2007, Pages 2910-2918

  Schmidt, Anke ^a   Haas, Stefan J P ^a   Hildebrandt, Steve ^a   Scheibe, Johanna ^a   Eckhoff, Birthe ^a   Racek, Tomáş ^a   Kempermann, Gerd ^b   Wree, Andreas ^a   Pützer, Brigitte M ^a,c  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^c Biomedical Research Center   (Germany)

Author keywords

Adenoviral vectors; Dentate gyrus; Gene therapy; Neural precursor stem cells; Phage display; pNestin green fluorescent protein transgenic mice

Indexed keywords

ADENOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; NESTIN; PEPTIDE LIBRARY;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DENTATE GYRUS; EMBRYO; GENE THERAPY; GENE TRANSFER; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; STEM CELL; VIRUS INFECTION;

ADENOVIRIDAE; ANIMALS; GENE THERAPY; GENETIC VECTORS; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; NIH 3T3 CELLS; PROTEIN BINDING; STEM CELLS;

ADENOVIRIDAE; MUS; MUS MUSCULUS;

EID: 36248966538     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0238     Document Type: Article

References (37)

1. Muller FJ, Snyder EY, Loring JF. Gene therapy: Can neural stem cells deliver? Nat Rev Neurosci 2006;7:75-84.
2. Palmer TD, Markakis EA, Willhoite AR et al. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci 1999;19:8487-8497.
3. Palmer TD, Takahashi J, Gage FH. The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci 1997;8:389-404.
4. Filippov V, Kronenberg G, Pivneva T et al. Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes. Mol Cell Neurosci 2003;23:373-382.
5. Doetsch F, Alvarez-Buylla A. Network of tangential pathways for neuronal migration in adult mammalian brain. Proc Natl Acad Sci U S A 1996;93:14895-14900.
6. Glass R, Synowitz M, Kronenberg G et al. Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival. J Neurosci 2005;25:2637-2646.
7. Chi L, Ke Y, Luo C et al. Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of amyotrophic lateral sclerosis mice. STEM CELLS 2006;24:34-43.
8. Parent JM. The role of seizure-induced neurogenesis in epileptogenesis and brain repair. Epilepsy Res 2002;50:179-189.
9. Kempermann G, Kronenberg G. Depressed new neurons: Adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol Psychiatry 2003;54:499-503.
10. Steiner B, Klempin F, Wang L et al. Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis. Glia 2006;54:805-814.
11. Ryu MY, Lee MA, Ahn YH et al. Brain transplantation of neural stem cells cotransduced with tyrosine hydroxylase and GTP cyclohydrolase 1 in Parkinsonian rats. Cell Transplant 2005;14:193-202.
12. Scheel JR, Ray J, Gage FH et al. Quantitative analysis of gene expression in living adult neural stem cells by gene trapping. Nat Methods 2005;2:363-370.
13. Geraerts M, Eggermont K, Hernandez-Acosta P et al. Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. Hum Gene Ther 2006;17:635-650.
14. Vroemen M, Weidner N, Blesch A. Loss of gene expression in lentivirusand retrovirus-transduced neural progenitor cells is correlated to migration and differentiation in the adult spinal cord. Exp Neurol 2005;195:127-139.
15. Schmidt A, Böckmann M, Stoll A et al. Analysis of adenovirus gene transfer into adult neural stem cells. Virus Res 2005;114:45-53.
16. Reynolds BA, Rietze RL. Neural stem cells and neurospheres: Reevaluating the relationship. Nat Methods 2005;2:333-336.
17. Kempermann G, Jessberger S, Steiner B et al. Milestones of neuronal development in the adult hippocampus. Trends Neurosci 2004;27:447-452.
18. Giordano RJ, Cardo-Vila M, Lahdenranta J et al. Biopanning and rapid analysis of selective interactive ligands. Nat Med 2001;7:1249-1253.
19. Böckmann M, Drosten M, Pützer BM. Discovery of targeting peptides for selective therapy of medullary thyroid carcinoma. J Gene Med 2005;7:179-188.
20. Alemany R, Curiel DT. CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors. Gene Ther 2001;8:1347-1353.
21. Pützer BM, Stiewe T, Parssanedjad K et al. E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products. Cell Death Differ 2000;7:177-188.
22. O'Riordan CR, Lachapelle A, Delgado C et al. PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo. Hum Gene Ther 1999;10:1349-1358.
23. Drapkin PT, O'Riordan CR, Yi SM et al. Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia. J Clin Invest 2000;105:589-596.
24. Romanczuk H, Galer CE, Zabner J et al. Modification of an adenoviral vector with biologically selected peptides: A novel strategy for gene delivery to cells of choice. Hum Gene Ther 1999;10:2615-2626.
25. Yamaguchi M, Saito H, Suzuki M et al. Visualization of neurogenesis in the central nervous system using nestin promoter-GFP transgenic mice. Neuroreport 2000;11:1991-1996.
26. Franklin KBJ, Paxinos G. The Mouse Brain in Stereotaxic Coordinates. San Diego: Academic Press, 1997.
27. Bergelson JM, Krithivas A, Celi L et al. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J Virol 1998;72:415-419.
28. Wickham TJ, Mathias P, Cheresh DA et al. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 1993;73:309-319.
29. Le Gal La Salle G, Robert JJ, Berrard S et al. An adenovirus vector for gene transfer into neurons and glia in the brain. Science 1993;259:988-990.
30. Zimmerman L, Parr B, Lendahl U et al. Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors. Neuron 1994;12:11-24.
31. Lin RC, Matesic DF, Marvin M et al. Re-expression of the intermediate filament nestin in reactive astrocytes. Neurobiol Dis 1995;2:79-85.
32. Thomas CE, Edwards P, Wickham TJ et al. Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types. J Virol 2002;76:3452-3460.
33. Seaberg RM, van der Kooy D. Adult rodent neurogenic regions: The ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. J Neurosci 2002;22:1784-1793.
34. Hitoshi S, Tropepe V, Ekker M et al. Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain. Development 2002;129:233-244.
35. Böckmann M, Hilken G, Schmidt A et al. Novel SRESPHP peptide mediates specific binding to primary medullary thyroid carcinoma after systemic injection. Hum Gene Ther 2005;16:1267-1275.
36. Thomas CE, Schiedner G, Kochanek S et al. Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases. Proc Natl Acad Sci U S A 2000;97:7482-7487.
37. Geddes BJ, Harding TC, Lightman SL et al. Long-term gene therapy in the CNS: Reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin. Nat Med 1997;3:1402-1404.