Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization

Journal of Neurochemistry

Volumn 103, Issue 5, 2007, Pages 2047-2057

  Lenicov, Federico Remes ^a   Lemonde, Sylvie ^a   Czesak, Margaret ^a   Mosher, Tera M ^a   Albert, Paul R ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Calcium; Promoter; RN46A; Serotonin; Transcription; Tryptophan hydroxylase

Indexed keywords

CALCIUM; CCAAT ENHANCER BINDING PROTEIN; DACTINOMYCIN; IONOMYCIN; IONOPHORE; LUCIFERASE; RNA; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR AP 2; TRYPTOPHAN HYDROXYLASE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL TYPE; CONTROLLED STUDY; EMBRYO; ENZYME ASSAY; ENZYME INDUCTION; ENZYME REGULATION; FEMALE; GENE CONSTRUCT; HUMAN; HUMAN CELL; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAPHE MAGNUS NUCLEUS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CALCIUM; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; IONOMYCIN; IONOPHORES; LUCIFERASES; MUTATION; NEURONS; PROMOTER REGIONS (GENETICS); RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ALIGNMENT; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TRYPTOPHAN HYDROXYLASE;

RATTUS;

EID: 36248964181     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04903.x     Document Type: Article

References (41)

1. Albert P. R. Tashjian A. H. Jr. (1984) Thyrotropin-releasing hormone-induced spike and plateau in cytosolic free Ca2+ concentrations in pituitary cells. Relation to prolactin release. J. Biol. Chem. 259, 5827 5832.
2. Albert P. R. Tashjian A. H. Jr. (1986) Ionomycin acts as an ionophore to release TRH-regulated Ca2+ stores from GH4C1 cells. Am. J. Physiol. 251, C887 C891.
3. Blakely R. D. (2005) Overview: a rare opportunity or just one less reason to be depressed. Neuron 48, 701 702 author reply 705 706.
4. Boadle-Biber M. C. (1993) Regulation of serotonin synthesis. Prog. Biophys. Mol. Biol. 60, 1 15.
5. Brown S. M., Peet E., Manuck S. B., Williamson D. E., Dahl R. E., Ferrell R. E. Hariri A. R. (2005) A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol. Psychiatry 10, 884 888.
6. Canli T., Congdon E., Gutknecht L., Constable R. T. Lesch K. P. (2005) Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J. Neural. Transm. 112, 1479 1485.
7. Cheng L., Chen C. L., Luo P., Tan M., Qiu M., Johnson R. Ma Q. (2003) Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. J. Neurosci. 23, 9961 9967.
8. Côté F., Thevenot E., Fligny C. et al. (2003) Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc. Natl Acad. Sci. USA 100, 13525 13530.
9. Czesak M., Burns A. M., Lenicov F. R. Albert P. R. (2007) Characterization of rat rostral raphe primary cultures: multiplex quantification of serotonergic markers. J. Neurosci. Methods 164, 59 67.
10. Eaton M. J., Staley J. K., Globus M. Y. Whittemore S. R. (1995) Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization. Dev. Biol. 170, 169 182.
11. Ehret M., Cash C. D., Hamon M. Maitre M. (1989) Formal demonstration of the phosphorylation of rat brain tryptophan hydroxylase by Ca2+/calmodulin- dependent protein kinase. J. Neurochem. 52, 1886 1891.
12. Flammer J. R., Popova K. N. Pflum M. K. (2006) Cyclic AMP response element-binding protein (CREB) and CAAT/enhancer-binding protein beta (C/EBPbeta) bind chimeric DNA sites with high affinity. Biochemistry 45, 9615 9623.
13. Hamon M., Bourgoin S., Artaud F. Glowinski J. (1979) The role of intraneuronal 5-HT and of tryptophan hydroxylase activation in the control of 5-HT synthesis in rat brain slices incubated in K+-enriched medium. J. Neurochem. 33, 1031 1042.
14. Hendricks T. J., Fyodorov D. V., Wegman L. J., Lelutiu N. B., Pehek E. A., Yamamoto B., Silver J., Weeber E. J., Sweatt J. D. Deneris E. S. (2003) Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron 37, 233 247.
15. Imagawa M., Chiu R. Karin M. (1987) Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell 51, 251 260.
16. Jollant F., Buresi C., Guillaume S., Jaussent I., Bellivier F., Leboyer M., Castelnau D., Malafosse A. Courtet P. (2007) The influence of four serotonin-related genes on decision-making in suicide attempters. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144, 615 624
17. Kilbourne E. J. Sabban E. L. (1990) Differential effect of membrane depolarization on levels of tyrosine hydroxylase and dopamine beta-hydroxylase mRNAs in PC12 pheochromocytoma cells. Brain Res. Mol. Brain Res. 8, 121 127.
18. Kumer S. C. Vrana K. E. (1996) Intricate regulation of tyrosine hydroxylase activity and gene expression. J. Neurochem. 67, 443 462.
19. de Lara C. L., Brezo J., Rouleau G., Lesage A., Dumont M., Alda M., Benkelfat C. Turecki G. (2007) Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression. Biol. Psychiatry 62, 72 80.
20. Lesch K. P. (2005) Serotonergic gene inactivation in mice: models for anxiety and aggression? Novartis Found. Symp. 268, 111 140 discussion 140 116 167 170.
21. Li L., He S., Sun J. M. Davie J. R. (2004) Gene regulation by Sp1 and Sp3. Biochem. Cell Biol. 82, 460 471.
22. Lovenberg W., Jequier E. Sjoerdsma A. (1967) Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor. Science 155, 217 219.
23. McCauslin C. S., Heath V., Colangelo A. M., Malik R., Lee S., Mallei A., Mocchetti I. Johnson P. F. (2006) CAAT/enhancer-binding protein delta and cAMP-response element-binding protein mediate inducible expression of the nerve growth factor gene in the central nervous system. J. Biol. Chem. 281, 17681 17688.
24. Menard C., Hein P., Paquin A. et al. (2002) An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis. Neuron 36, 597 610.
25. Moret C. Briley M. (1997) 5-HT autoreceptors in the regulation of 5-HT release from guinea pig raphe nucleus and hypothalamus. Neuropharmacology 36, 1713 1723.
26. Morgan J. I. Curran T. (1988) Calcium as a modulator of the immediate-early gene cascade in neurons. Cell Calcium 9, 303 311.
27. Nagamoto-Combs K., Piech K. M., Best J. A., Sun B. Tank A. W. (1997) Tyrosine hydroxylase gene promoter activity is regulated by both cyclic AMP-responsive element and AP1 sites following calcium influx. Evidence for cyclic amp-responsive element binding protein-independent regulation. J. Biol. Chem. 272, 6051 6058.
28. Patel P. D., Pontrello C. Burke S. (2004) Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol. Psychiatry 55, 428 433.
29. Patel P. D., Bochar D. A., Turner D. L., Meng F., Mueller H. M. Pontrello C. G. (2007) Regulation of tryptophan hydroxylase-2 gene expression by a bipartite REST/NRSF binding motif. J. Biol. Chem. Epub ahead of print.
30. Penington N. J., Kelly J. S. Fox A. P. (1991) A study of the mechanism of Ca2+ current inhibition produced by serotonin in rat dorsal raphe neurons. J. Neurosci. 11, 3594 3609.
31. Rumajogee P., Verge D., Hanoun N., Brisorgueil M. J., Hen R., Lesch K. P., Hamon M. Miquel M. C. (2004) Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP. Eur. J. Neurosci. 19, 937 944.
32. Scheuch K., Lautenschlager M., Grohmann M., Stahlberg S., Kirchheiner J., Zill P., Heinz A., Walther D. J. Priller J. (2007) Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biol. Psychiatry Epub ahead of print.
33. Walitza S., Renner T. J., Dempfle A. et al. (2005) Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Mol. Psychiatry 10, 1126 1132.
34. Walther D. J., Peter J. U., Bashammakh S., Hortnagl H., Voits M., Fink H. Bader M. (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299, 76.
35. White L. A., Eaton M. J., Castro M. C., Klose K. J., Globus M. Y., Shaw G. Whittemore S. R. (1994) Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons. J. Neurosci. 14, 6744 6753.
36. Whittemore S. R. White L. A. (1993) Target regulation of neuronal differentiation in a temperature-sensitive cell line derived from medullary raphe. Brain Res. 615, 27 40.
37. Wrase J., Reimold M., Puls I., Kienast T. Heinz A. (2006) Serotonergic dysfunction: brain imaging and behavioral correlates. Cogn. Affect. Behav. Neurosci. 6, 53 61.
38. Zhang X., Beaulieu J. M., Sotnikova T. D., Gainetdinov R. R. Caron M. G. (2004) Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305, 217.
39. Zhang X., Gainetdinov R. R., Beaulieu J. M., Sotnikova T. D., Burch L. H., Williams R. B., Schwartz D. A., Krishnan K. R. Caron M. G. (2005) Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11 16.
40. Zill P., Buttner A., Eisenmenger W., Moller H. J., Bondy B. Ackenheil M. (2004a) Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol. Psychiatry 56, 581 586.
41. Zill P., Baghai T. C., Zwanzger P., Schule C., Eser D., Rupprecht R., Moller H. J., Bondy B. Ackenheil M. (2004b) SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol. Psychiatry 9, 1030 1036.