Coenzyme Q10 does not protect cochlear hair cells from death in the ischemic organotypic culture

Otolaryngology - Head and Neck Surgery

Volumn 137, Issue 6, 2007, Pages 950-952

  Khan, Martin ^a   Amarjargal, Nyamaa ^a   Gross, Johann ^a   Haupt, Heidemarie ^a   Scherer, Hans ^a   Mazurek, Birgit ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

UBIDECARENONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL LOSS; CELL PROTECTION; COCHLEA; CONTROLLED STUDY; HAIR CELL; HYPOTHESIS; ISCHEMIA; NEWBORN; NONHUMAN; RAT;

ANIMALS; ANIMALS, NEWBORN; CARBON DIOXIDE; CELL DEATH; CELL SURVIVAL; COENZYMES; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; HAIR CELLS, AUDITORY; ISCHEMIA; NITROGEN; ORGAN CULTURE TECHNIQUES; PERILYMPH; PROTECTIVE AGENTS; RATS; RATS, WISTAR; UBIQUINONE;

EID: 36149000164     PISSN: 01945998     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.otohns.2007.09.001     Document Type: Article

References (5)

1. Khan M., Gross J., Haupt H., et al. A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngol Head Neck Surg 136 (2007) 72-77
2. Mazurek B., Winter E., Fuchs J., et al. Susceptibility of the hair cells of the newborn rat cochlea to hypoxia and ischemia. Hear Res 182 (2003) 2-8
3. Sha S.H., Taylor R., Forge A., et al. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 155 (2001) 1-8
4. Sato K. Pharmacokinetics of coenzyme Q10 in recovery of acute sensorineural hearing loss due to hypoxia. Acta Otolaryngol Suppl 458 (1988) 95-102
5. Henke W., and Jung K. Ischemia decreases the content of the adenine nucleotide translocator in mitochondria of rat kidney. Biochim Biophys Acta 1056 (1991) 71-75