Effect of nicotinamide administration on the tryptophan-nicotinamide pathway in humans

International Journal for Vitamin and Nutrition Research

Volumn 77, Issue 4, 2007, Pages 255-262

  Fukuwatari, Tsutomu ^a   Shibata, Katsumi ^a  

^a UNIVERSITY OF SHIGA PREFECTURE   (Japan)

Author keywords

Feedback inhibition; Human; Kynurenine pathway; NAD; Nicotinamide; Tryptophan; Urine

Indexed keywords

3 HYDROXYANTHRANILIC ACID; ANTHRANILIC ACID; KYNURENIC ACID; NICOTINAMIDE; NICOTINIC ACID; QUINOLINIC ACID; TRYPTOPHAN; XANTHURENIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; URINARY EXCRETION;

3-HYDROXYANTHRANILIC ACID; ADULT; ANTHRANILIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEEDBACK, BIOCHEMICAL; FEMALE; HUMANS; KYNURENIC ACID; NIACINAMIDE; QUINOLINIC ACID; TRYPTOPHAN; XANTHURENATES;

EID: 36148983789     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.77.4.255     Document Type: Article

References (33)

1. Shibata, K., Taguchi, H. and Iwai, K. (1991) Regulation of pyridine nucleotide coenzyme metabolism. Adv. Exp. Med. Biol. 294, 649.
2. Horwitt, M. K., Harvey, C. C., Rothwell, W. S., Cutler, J. L. and Haffron, D. (1956) Tryptophan-niacin relationships in man. Studies with diets deficient in riboflavin and niacin, together with observations on the excretion of nitrogen and niacin metabolites. J. Nutr. 60 Suppl. 1, 1.
3. Wertz, A. W., Lojkin, M. E., Bouchard, B. S. and Derby, M. B. (1958) Tryptophan-niacin relationships in pregnancy. J. Nutr. 64, 339.
4. Goldsmith, G. A., Miller, O. N. and Unglaub, W. G. (1961) Efficiency of tryptophan as a niacin precursor in man. J. Nutr. 73, 172.
5. Horwitt, M. K. (1958) Niacin-tryptophan requirements of man. J. Am. Diet Assoc. 34, 914.
6. Nakagawa, I., Takahashi, T., Suzuki, T. and Masana, Y. (1969) Effect in man of the addition of tryptophan or niacin to the diet on the excretion of their metabolites. J. Nutr. 99, 325.
7. Nakagawa, I., Takahashi, T., Sasaki, A., Kajimoto, M. and Suzuki, T. (1973) Efficiency of conversion of tryptophan to niacin in humans. J. Nutr. 103, 1195.
8. Murata, K. and Motooka, K. (1980) Conversion ratio of tryptophan to niacin in healthy women. J. Jpn. Soc. Nutr. Food Sci. 33, 339.
9. The Ministry of Health, Labour, and Welfare. (2004) Dietary Reference Intakes for Japanese, 2005.
10. Horwitt, M. K., Harper, A. E. and Henderson, L. M. (1981) Niacin-tryptophan relationships for evaluating niacin equivalents. Am. J. Clin. Nutr. 34, 423.
11. Shibata, K., Mushiage, M., Kondo, T., Hayakawa, T. and Tsuge, H. (1995) Effects of vitamin B6 deficiency on the conversion ratio of tryptophan to niacin. Biosci. Biotechnol. Biochem. 59, 2060.
12. Shibata, K., Kondo, T. and Yonezima, M. (1997) Conversion ratio of tryptophan to niacin in rats fed a vitamin B1-free diet. J. Nutr. Sci. Vitaminol. 43, 479.
13. Kimura, N., Fukuwatari, T., Sasaki, R., and Shibata, K. (2005) The necessity of niacin in rats fed on a high protein diet. Biosci. Biotechnol. Biochem. 69, 273.
14. Shibata, K. (1995) Effects of adrenalin on the conversion ratio of tryptophan to niacin in rats. Biosci. Biotechnol. Biochem. 59, 2127.
15. Shibata, K., and Toda, S. (1997) Effects of sex hormones on the metabolism of tryptophan to niacin and to serotonin in male rats. Biosci. Biotechnol. Biochem. 61, 1200.
16. Shibata, K., Kondo, T. and Miki, A. (1998) Increased conversion ratio of tryptophan to niacin in severe food restriction. Biosci. Biotechnol. Biochem. 62, 580.
17. Fukuwatari, T., Shibata, K., Ishikawa, K., Fushiki, T. and Sugimoto, E. (2001) Elevation of blood NAD level after moderate exercise in young women and mice. J. Nutr. Sci. Vitaminol. 47, 177.
18. Shibata, K., Kondo, T., Marugami, M. and Umezawa, C. (1996) Increased conversion ratio of tryptophan to niacin by the administration of clofibrate, a hypolipidemic drug, to rats. Biosci. Biotechnol. Biochem. 60, 1455.
19. Shibata, K., Ishikawa, A. and Kondo, T. (1997) Effects of dietary pyrazinamide on the metabolism of tryptophan to niacin in streptozotocin- diabetic rats. Biosci. Biotechnol. Biochem. 61, 1679.
20. Shibata, K., Fukuwatari, T., Enomoto, A. and Sugimoto, E. (2001) Increased conversion ratio of niacin by dietary di-n-butylphthalate. J. Nutr. Sci. Vitaminol. 47, 263.
21. Fukuwatari, T., Ohta, M., Sugimoto, E., Sasaki, R. and Shibata, K. (2004) Effects of dietary di(2-ethylhexyl)phthalate, a putative endocrine disrupter, on enzyme activities involved in the metabolism of tryptophan to niacin in rats. Biochim. Biophys. Acta, 1672, 67.
22. Kimura, N., Fukuwatari, T., Sasaki, R., Hayakawa, F. and Shibata, K. (2003) Vitamin intake in Japanese women college students. J. Nutr. Sci. Vitaminol. 49, 149.
23. Cho-Chung, Y. S. and Pilot, H. C. (1967) Feedback control of rat liver tryptophan pyrrolase. I. End product inhibition of tryptophan pyrrolase activity. J. Biol. Chem. 242, 1192.
24. Fukuwatari, T., Wada, H., Sasaki, R. and Shibata, K. (2004) Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats. Biosci. Biotechnol. Biochem. 68, 44.
25. 1-methylnicotinamide. J. Biol. Chem. 206, 121.
26. 1-methyl-4- pyridone-3-carboxamide, by high-performance liquid chromatography. J. Chromatogr. 424, 23.
27. Resources Council, Science and Technology Agency. (2000) Standard Tables of Food Composition in Japan. 5th ed. The Printing Bureau, The Minister of Finance. Tokyo.
28. 1-methylnicotinamide in urine by high-performance liquid chromatography. Vitamins 61, 599.
29. Shibata, K. (1988). Fluorimetric micro-determination of kynurenic acid, as endogenous blocker of neurotoxicity, by high-performance liquid chromatography. J. Chromatogr. 430, 376.
30. Shibata, K. and Onodera, M. (1992) Simultaneous high-performance liquid chromatographic measurement of xanthurenic acid and 3-hydroxyanhranilic acids in urine. Biosci. Biotechnol. Biochem. 56, 974.
31. Shibata, K. and Onodera, M. (1991) Measurement of 3-hydroxyanthranilic acid and anthranilic acid in urine by high-performance liquid chromatography. Agric. Biol. Chem. 55, 143.
32. Mawatari, K., Oshida, K., Iinuma, F. and Watanabe, M. (1995) Determination of quinolinic acid in human urine by liquid chromatography with fluorimetric detection. Anal. Chim. Acta 302, 179.
33. Shibata, K., Taguchi, H., Nishitani, H., Okumura, K., Shimabayashi, Y., Matsushita, N. and Yamazaki, H. (1989) End product inhibition of the activity of nicotinamide phosphoribosyltransferase from various tissues of rats by NAD. Agric. Biol. Chem. 53, 2283.