The energetic state within hibernating myocardium is normal during dobutamine despite inhibition of ATP-dependent potassium channel opening with glibenclamide

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 5, 2007, Pages

  McFalls, Edward O ^a,b   Kelly, Rosemary F ^a   Hu, Qingsong ^a   Mansoor, Abdul ^a   Lee, Joseph ^a   Kuskowski, Michael ^a   Sikora, Joseph ^a   Ward, Herbert B ^a   Zhang, Jianyi ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b VA MEDICAL CENTER   (United States)

Author keywords

Hibernation; High energy phosphates; Mitochondrial adaptations; Myocardial ischemia; Preconditioning

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; DOBUTAMINE; GLIBENCLAMIDE; PHOSPHORUS 31; POTASSIUM CHANNEL;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; HEART MUSCLE; HEART MUSCLE ISCHEMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN SUPPLY; PERFUSION; PRIORITY JOURNAL; SWINE; THORACOTOMY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARDIOTONIC AGENTS; DOBUTAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENERGY METABOLISM; GLYBURIDE; HYPOGLYCEMIC AGENTS; ION CHANNEL GATING; MYOCARDIAL STUNNING; POTASSIUM CHANNELS; SWINE;

EID: 36148932951     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00012.2007     Document Type: Article

References (19)

1. Canty J, Fallavollita J. Chronic hibernation and chronic stunning: a continuum. J Nucl Cardiol 7: 509-527, 2000.
2. ATP opening on heart mitochondria. Am J Physiol Heart Circ Physiol 290: H406-H415, 2006.
3. 2+ ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium. Am J Physiol Heart Circ Physiol 277: H1418-H1428, 1999.
4. Fallavollita J, Malm BJ, Canty JM Jr. Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest. Circ Res 92: 48-55, 2003.
5. 18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium: evidence for transmural variations in chronic hibernating myocardium. Circulation 95: 1900-1909, 1997.
6. Gong G, Liu J, Liang P, Guo T, Hu Q, Ochiai K, Hou M, Ye Y, Wu X, Mansoor A, From AH, Ugurbil K, Bache RJ, Zhang J. Oxidative capacity in failing hearts. Am J Physiol Heart Circ Physiol 285: H541-H548, 2003.
7. Martin C, Schulz R, Rose J, Heusch G. Inorganic phosphate content and free energy change of ATP hydrolysis in regional short-term hibernating myocardium. Cardiovasc Res 39: 318-326, 1998.
8. McFalls E, Baldwin D, Palmer B, Marx D, Jaimes D, Ward H. Regional glucose uptake within hypoperfused swine myocardium as measured by PET. Am J Physiol Heart Circ Physiol 272: H343-H349, 1997.
9. McFalls E, Hou M, Bache R, Best A, Marx D, Sikora J, Ward HB. Activation of p38 MAPK and increased glucose transport in chronic hibernating swine myocardium. Am J Physiol Heart Circ Physiol 287: H1328-H1334, 2004.
10. McFalls E, Sluiter W, Schoonderwoerd K, Manintveld O, Lamers J, Bezstarosti B, van Beusekom HM, Sikora J, Ward HB, Merkus D, Duncker DJ. Mitochondrial adaptations within chronically ischemic swine myocardium. J Mol Cell Cardiol 41: 980-988, 2006.
11. Mills I, Fallon J, Wrenn D, Sasken H, Gray W, Bier J, et al. Adaptive responses of coronary circulation and myocardium to chronic reduction in perfusion pressure and flow. Am J Physiol Heart Circ Physiol 266: H447-H457, 1994.
12. Murakami Y, Zhang Y, Cho Y, Mansoor A, Chung J, Chu C, Francis G, Ugurbil K, Bache RJ, From AH, Jerosch-Herold M, Wilke N, Zhang J. Myocardial oxygenation during high work states in hearts with post-infarction remodeling. Circulation 99: 942-948, 1999.
13. Neubauer S, Horn M, Cramer M, Harre K, Newell J, Peters W, et al. Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation 96: 2190-2196, 1997.
14. ATP channel triggers delayed ischemic preconditioning in rats. Am J Physiol Heart Circ Physiol 288: H445-H447, 2005.
15. Rahimtoola S. The hibernating myocardium. Am Heart J 117: 211-221, 1989.
16. Schulz R, Rose J, Heusch G. Involvement of activation of ATP-dependent potassium channels in ischemic preconditioning in swine. Am J Physiol Heart Circ Physiol 267: H1341-H1352, 1994.
17. Schulz R, Rose J, Post H, Heusch G. Regional short-term hibernation in swine does not involve endogenous adenosine or KATP channels. Am J Physiol Heart Circ Physiol 268: H2294-H3201, 1995.
18. Vanoverschelde J, Wijns W, Borgers M, Heyndrickx G, Depre C, Flameng W, Melin JA. Chronic myocardial hibernation in humans: from bedside to bench. Circulation 95: 1961-1971, 1997.
19. Zhang J, McDonald K. Bioenergetic consequences of left ventricular remodeling. Circulation 92: 1011-1019, 1995.