Interleukin-6 -174 promoter polymorphism does not influence IL-6 production after LPS and IL-1β stimulation in human umbilical cord vein endothelial cells

Cytokine

Volumn 40, Issue 1, 2007, Pages 17-22

  Kiszel, Petra ^a   Makó, Veronika ^a   Prohászka, Zoltán ^a,b   Cervenak, László ^b  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

HUVEC; IL 6 174 G C polymorphism; Interleukin 6

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6;

ARTICLE; CELL DIFFERENTIATION; ENDOTHELIUM CELL; GENE FREQUENCY; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; UMBILICAL VEIN;

3' UNTRANSLATED REGIONS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE FREQUENCY; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); UMBILICAL CORD; UMBILICAL VEINS;

EID: 36049031170     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2007.08.001     Document Type: Article

References (41)

1. Kishimoto T. Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res Ther 8 Suppl. 2 (2006) S2
2. Sehgal P.B. Interleukin-6: a regulator of plasma protein gene expression in hepatic and non-hepatic tissues. Mol Biol Med 7 (1990) 117-130
3. May L.T., Torcia G., Cozzolino F., Ray A., Tatter S.B., Santhanam U., et al. Interleukin-6 gene expression in human endothelial cells: RNA start sites, multiple IL-6 proteins and inhibition of proliferation. Biochem Biophys Res Commun 159 (1989) 991-998
4. Ridker P.M., Rifai N., Stampfer M.J., and Hennekens C.H. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101 (2000) 1767-1772
5. Biasucci L.M., Vitelli A., Liuzzo G., Altamura S., Caligiuri G., Monaco C., et al. Elevated levels of interleukin-6 in unstable angina. Circulation 94 (1996) 874-877
6. Hack C.E., De Groot E.R., Felt-Bersma R.J., Nuijens J.H., Strack Van Schijndel R.J., Eerenberg-Belmer A.J., et al. Increased plasma levels of interleukin-6 in sepsis. Blood 74 (1989) 1704-1710
7. Blackwell T.S., and Christman J.W. Sepsis and cytokines: current status. Br J Anaesth 77 (1996) 110-117
8. Inoue T., and Node K. Vascular failure: a new clinical entity for vascular disease. J Hypertens 24 (2006) 2121-2130
9. Aird W.C. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101 (2003) 3765-3777
10. Aird W.C. Phenotypic heterogeneity of the endothelium: II. Representative vascular beds. Circ Res 100 (2007) 174-190
11. Aird W.C. Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ Res 100 (2007) 158-173
12. Kitamura A., Hasegawa G., Obayashi H., Kamiuchi K., Ishii M., Yano M., et al. Interleukin-6 polymorphism (-634C/G) in the promotor region and the progression of diabetic nephropathy in type 2 diabetes. Diabet Med 19 (2002) 1000-1005
13. Muller-Steinhardt M., Ebel B., and Hartel C. The impact of interleukin-6 promoter -597/-572/-174 genotype on interleukin-6 production after lipopolysaccharide stimulation. Clin Exp Immunol 147 (2007) 339-345
14. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102 (1998) 1369-1376
15. Ray A., LaForge K.S., and Sehgal P.B. On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion. Mol Cell Biol 10 (1990) 5736-5746
16. Belluco C., Olivieri F., Bonafe M., Giovagnetti S., Mammano E., Scalerta R., et al. -174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer. Clin Cancer Res 9 (2003) 2173-2176
17. Humphries S.E., Luong L.A., Ogg M.S., Hawe E., and Miller G.J. The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J 22 (2001) 2243-2252
18. Libra M., Signorelli S.S., Bevelacqua Y., Navolanic P.M., Bevelacqua V., Polesel J., et al. Analysis of G(-174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease. J Clin Pathol 59 (2006) 211-215
19. Greisenegger S., Endler G., Haering D., Schillinger M., and Lang W. The (-174) G/C polymorphism in the interleukin-6 gene is associated with the severity of acute cerebrovascular events. Thromb Res 110 (2003) 181-186
20. Chapman C.M., Beilby J.P., Humphries S.E., Palmer L.J., Thompson P.L., and Hung J. Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population. Eur Heart J 24 (2003) 1494-1499
21. Jones K.G., Brull D.J., Brown L.C., Sian M., Greenhalgh R.M., Humphries S.E., et al. Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation 103 (2001) 2260-2265
22. Veres A., Prohaszka Z., Kilpinen S., Singh M., Fust G., and Hurme M. The promoter polymorphism of the IL-6 gene is associated with levels of antibodies to 60-kDa heat-shock proteins. Immunogenetics 53 (2002) 851-856
23. Kiszel P., Fust G., Pessi T., Hurme M., and Prohaszka Z. Associations between interleukin-6 genetic polymorphisms and levels of autoantibodies to 60-kDa heat-shock proteins. Hum Hered 62 (2006) 77-83
24. Hegedus C.M., Skibola C.F., Bracci P., Holly E.A., and Smith M.T. Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphism. Proteomics 7 (2007) 548-557
25. Oroszlan M., Herczenik E., Rugonfalvi-Kiss S., Roos A., Nauta A.J., Daha M.R., et al. Proinflammatory changes in human umbilical cord vein endothelial cells can be induced neither by native nor by modified CRP. Int Immunol 18 (2006) 871-888
26. Blankenberg S., Barbaux S., and Tiret L. Adhesion molecules and atherosclerosis. Atherosclerosis 170 (2003) 191-203
27. Yao J.S., Zhai W., Young W.L., and Yang G.Y. Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9. Biochem Biophys Res Commun 342 (2006) 1396-1404
28. Maruo N., Morita I., Shirao M., and Murota S. IL-6 increases endothelial permeability in vitro. Endocrinology 131 (1992) 710-714
29. Randall T.D., Lund F.E., Brewer J.W., Aldridge C., Wall R., and Corley R.B. Interleukin-5 (IL-5) and IL-6 define two molecularly distinct pathways of B-cell differentiation. Mol Cell Biol 13 (1993) 3929-3936
30. Yoshida S., Sotozono C., Ikeda T., and Kinoshita S. Interleukin-6 (IL-6) production by cytokine-stimulated human Muller cells. Curr Eye Res 22 (2001) 341-347
31. Martin M.U., and Wesche H. Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family. Biochim Biophys Acta 1592 (2002) 265-280
32. Kilpinen S., Hulkkonen J., Wang X.Y., and Hurme M. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. Eur Cytokine Netw 12 (2001) 62-68
33. Olivieri F., Bonafe M., Cavallone L., Giovagnetti S., Marchegiani F., Cardelli M., et al. The -174 C/G locus affects in vitro/in vivo IL-6 production during aging. Exp Gerontol 37 (2002) 309-314
34. Rivera-Chavez F.A., Peters-Hybki D.L., Barber R.C., and O'Keefe G.E. Interleukin-6 promoter haplotypes and interleukin-6 cytokine responses. Shock 20 (2003) 218-223
35. Olivieri F., Bonafe M., Giovagnetti S., Stecconi R., Cardelli M., Cavallone L., et al. In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging. Mech Ageing Dev 124 (2003) 549-553
36. Boiardi L., Casali B., Farnetti E., Pipitone N., Nicoli D., Cantini F., et al. Relationship between interleukin 6 promoter polymorphism at position -174, IL-6 serum levels, and the risk of relapse/recurrence in polymyalgia rheumatica. J Rheumatol 33 (2006) 703-708
37. Bittar MN, Carey JA, Barnard J, Fildes JE, Pravica V, Yonan N, Hutchinson IV. Interleukin 6 G-174C polymorphism influences outcome following coronary revascularization surgery. Heart Surg Forum 2005;8:E140-5; discussion E5.
38. Endler G., Marsik C., Joukhadar C., Marculescu R., Mayr F., and Mannhalter C. The interleukin-6 G(-174)C promoter polymorphism does not determine plasma interleukin-6 concentrations in experimental endotoxemia in humans. Clin Chem 50 (2004) 195-200
39. Walston J., Arking D.E., Fallin D., Li T., Beamer B., Xue Q., et al. IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women. Exp Gerontol 40 (2005) 344-352
40. Schluter B., Raufhake C., Erren M., Schotte H., Kipp F., Rust S., et al. Effect of the interleukin-6 promoter polymorphism (-174 G/C) on the incidence and outcome of sepsis. Crit Care Med 30 (2002) 32-37
41. Sipahi T., Pocan H., and Akar N. Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis. Clin Appl Thromb Hemost 12 (2006) 47-54