Acetyl-[Asn30,Tyr32]-calcitonin fragment 8-32 forms channels in phospholipid planar lipid membranes

European Biophysics Journal

Volumn 36, Issue 7, 2007, Pages 763-770

  Meleleo, Daniela ^a   Gallucci, Enrico ^a   Picciarelli, Vittorio ^a   Micelli, Silvia ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Ion channel; Planar lipid membrane; Salmon calcitonin; Truncated salmon calcitonin (8 32)

Indexed keywords

DIOLEOYLPHOSPHATIDYLGLYCEROL; PHOSPHOLIPID; SALCATONIN; 1,2 DIOLEOYL SN GLYCERO 3 PHOSPHOGLYCEROL; 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOGLYCEROL; 1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE; 2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; CALCITONIN; ION CHANNEL; PEPTIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; UNCLASSIFIED DRUG;

BIOTECHNOLOGY; CONFERENCE PAPER; LIFESPAN; LIPID MEMBRANE; NONHUMAN; PH; PROTEIN INTERACTION; ANIMAL; ARTICLE; ARTIFICIAL MEMBRANE; CHANNEL GATING; CHEMISTRY; PHYSIOLOGY;

ANIMALS; CALCITONIN; ION CHANNEL GATING; ION CHANNELS; MEMBRANES, ARTIFICIAL; PEPTIDES; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLGLYCEROLS;

EID: 36049018604     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-007-0150-6     Document Type: Conference Paper

References (39)

1. Amodeo P, Motta A, Straziullo G, Castiglione Morelli MA (1999) Conformational flexibility in calcitonin: the dynamic properties of human and salmon calcitonin in solution. J Biomol NMR 13:161-174
2. Azria M (1989) The calcitonins: physiology and pharmacology. Karger, Basel
3. Beaumont K, Moore CX, Pittner RA, Prickett KS, Gaeta LS, Rink TJ, Young AA (1995a) Differential antagonism of amylin's metabolic and vascular actions with amylin receptor antagonists. Can J Physiol Pharmacol 73:1025-1029
4. Beaumont K, Pittner RA, Moore CX, Wolfe-Lopez D, Prickett KS, Young AA, Rink TJ (1995b) Regulation of muscle glycogen metabolism by CGRP and amylin: CGRP receptors not involved. Br J Pharmacol 115:713-715
5. Boichot S, Krauss U, Plenat T, Rennert R, Milhiet PE, Beck-Sickinger A, Le Grimellec C (2004) Calcitonin-derived carrier peptide plays a major role in the membrane localization of a peptide-cargo complex. FEBS Lett 569:346-350
6. Bradshaw JP (1997) Phosphatidylglycerol promotes bilayer insertion of salmon calcitonin. Biophys J 72:2180-86
7. Chambers TJ, Magnus CJ (1982) Calcitonin alters behaviour of isolated osteoclasts. J Pathol 136:27-39
8. Cudd A, Arvinte T, Das RE, Chinni C, McIntyre I (1995) Enhanced potency of human calcitonin when fibrillation is avoided. J Pharm Sci 84:717-719
9. Davies SMA, Kelly SM, Price NC, Bradshaw JP (1998) Structural plasticity of the feline leukaemia virus fusion peptide: a circular dichroism study. FEBS Lett 425:415-418
10. Deber CM, Li S-C (1995) Peptides in membranes: helicity and hydrophobicity. Biopolymers 37:295-318
11. Diociaiuti M, Zanetti Polsi L, Valvo L, Malchiodi-Alfedi F, Bombelli C, Gaudiano MC (2006) Calcitonin forms oligomeric pore-like structures in lipid membranes. Biophys J 91:2275-2281
12. Disa J, Dang K, Tan KB, Aiyar N (1998) Interaction of adrenomedullin with calcitonin receptor in cultured human breast cancer cells, T 47D. Peptides 19:247-251
13. Gallucci E, Meleleo D, Micelli S, Picciarelli V (2003) Magainin2 channel formation in planar lipid membranes: the role of lipid polar groups and ergosterol. Eur Biophys J 32:22-32
14. Harris PJ, Cooper ME, Hiranyachattada S, Bera JL, Kelly DJ, Nobes M, Wookey PJ (1997) Amylin stimulates proximal tubular sodium transport and cell proliferation in the rat kidney. Am J Physiol 272:F13-F21
15. Herbig ME, Weller K, Krauss U, Beck-Sickinger AG, Merkle HP, Zerbe O (2005) Membrane surface-associated helices promote lipid interactions and cellular uptake of human calcitonin-derived cell penetrating peptides. Biophys J 89:4056-4066
16. Hilton JM, Dowton M, Houssami S, Sexton PM (2000) Identification of key components in the irreversibility of salmon calcitonin binding to calcitonin receptors. J Endocrinol 166:213-226
17. Kaneez FS, White M (2004) Patch clamp study of Serotonin-gated currents via 5-HT type 3 receptors by using a novel approach SHAM for receptor channel scanning. J Biomed Biotechnol 2004:10-15
18. Kapurniato A, Taylor JW (1995) Structural and conformational requirements for human calcitonin activity: design synthesis, and study of lactam-bridged analogues. J Med Chem 38:836-847
19. Krauss U, Kratz F, Beck-Sickinger AG (2003) Novel daurobicin-carrier peptide conjugates derived from human calcitonin segments. J Mol Recognit 16:280-287
20. Krauss U, Muller M, Stahl M, Beck-Sickinger AG (2004) In vitro gene delivery by a novel human calcitonin (hCT)-derived carrier peptide. Bioorg Med Chem Lett 14:51-54
21. Lutz TA, Tschudya S, Rushing PA, Scharrera E (2000) Amylin receptors mediate the anorectic action of salmon calcitonin (sCT). Peptides 21:233-238
22. Machova Z, Muhle C, Krauss U, Trehin R, Koch A, Merkle HP, Beck-Sickinger AG (2002) Cellular internalization of enhanced green fluorescent protein ligated to a human calcitonin-based carrier peptide. Chembiochem 3:672-677
23. MacIntyre I, Parsons LA, Robinson CJ (1967) The effect of thyrocalcitonin on blood bone calcium equilibrium in the perfused tibiae of the cat. J Physiol 191:393-405
24. MacIntyre I, Stevenson JC, Whitehead MI, Wimalawansa SJ, Banks LM, Healy MJ (1988) Calcitonin for prevention of postmenopausal bone loss. Lancet 8591:900-902
25. Meleleo D, Micelli S, Toma K, Haneda K, Gallucci E (2006) Effect of eel calcitonin glycosylation on incorporation and channel formation in planar phospholipid membranes. Peptides 27:805-811
26. Micelli S, Meleleo D, Picciarelli V, Stoico MG, Gallucci E (2004) Effect of nanomolar concentrations of sodium dodecyl sulfate-a catalytic inductor of α-helices on human calcitonin incorporation and channel formation in planar lipid membranes. Biophys J 87:1065-1075
27. Micelli S, Meleleo D, Picciarelli V, Gallucci E (2006) Effect of pH-variation on insertion and ion channel formation of human calcitonin into planar lipid bilayers. Front Biosci 11:2035-2044
28. Nicholson GC, Moseley JM, Sexton PM, Mendelsohn FA, Martin TJ (1986) Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization. J Clin Invest 78:355-360
29. Pham V, Dong M, Wade JD, Miller IJ, Morton CJ, Ng HL, Parker MW, Sexton PM (2005) Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling. J Biol Chem 280:28610-28622
30. Pozvek G, Hilton JM, Quiza M, Houssami S, Sexton PM (1997) Structure/function relationships of calcitonin analogues as agonists, antagonists, or inverse agonists in a constitutively activated receptor cell system. Mol Pharmacol 51:658-665
31. Sargent DF, Schwyzer R (1986) Membrane lipid phase as catalyst for peptide-receptor interactions. Proc Natl Acad Sci USA 83:5774-5778
32. Schmidt MC, Rothen-Rutishauser B, Rist B, Beck-Sickinger AG, Wunderly-Allenspach H, Rubas Sadée W, Merkle HP (1998) Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membranes. Biochemistry 37:16582-16590
33. Silverman SL (1997) Calcitonin. Am J Med Sci 313:13-16
34. Silvestre RA, Salas M, Rodriguez-Gallardo J, Garcia-Hermida O, Fontela T, Marco J (1996) Effect of (8-32) salmon calcitonin, an amylin antagonist, on insulin, glucagon and somatostatin release: study in the perfused pancreas of the rat. Br J Pharmacol 117:347-350
35. Stipani V, Gallucci E, Micelli S, Picciarelli V, Benz R (2001) Channel formation by salmon and human calcitonin in black lipid membranes. Biophys J 81:3332-3338
36. Stroop SD, Nakamuta H, Kuestner RE, Moore EE, Epand RM (1996) Determinants for calcitonin analog interaction with the calcitonin receptor N-terminus and transmembrane-loop regions. Endocrinology 137:4752-6475
37. Wagner K, Van Mau N, Boichot S, Kajava AV, Krauss U, Grimellec CL, Beck-Sickinger AG, Heitz F (2004) Interactions of the human calcitonin fragment 9-32 with phospholipids: a molecular study. Biophys J 87:386-395
38. Young AA, Gedulin B, Gaeta LS, Prickett KS, Beaumont K, Larson E, Rink TJ (1994) Selective amylin antagonist suppresses rise in plasma lactate after intravenous glucose in the rat: evidence for a metabolic role of endogenous amylin. FEBS Lett 343:237-241
39. Young AA (1995) Lactate production from the rat hindlimb is increased after glucose-administration and is suppressed by a selective amylin antagonist: evidence for action of endogenous amylin in skeletal muscle. Biochem Biophys Res Commun 216:554-559