Moxidectin interference on sexual behavior, penile erection and hypothalamic GABA levels of male rats

Research in Veterinary Science

Volumn 84, Issue 1, 2008, Pages 100-106

  Rodrigues Alves, Patricia S B ^a   Lebrun, Ivo ^b   Flório, Jorge Camilo ^a   Bernardi, Maria M ^a   Spinosa, Helenice de S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

Author keywords

GABA; GABAergic receptors; Moxidectin; Penile erection; Sexual behavior

Indexed keywords

4 AMINOBUTYRIC ACID; MOXIDECTIN;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ERECTILE DYSFUNCTION; FEMALE; HYPOTHALAMUS; MALE; MOTIVATION; NONHUMAN; PENIS ERECTION; RAT; REPRODUCTIVE TOXICITY; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION;

ANIMALS; ANTHELMINTICS; FEMALE; GAMMA-AMINOBUTYRIC ACID; HYPOTHALAMUS; MACROLIDES; MALE; PENILE ERECTION; RATS; SEXUAL BEHAVIOR, ANIMAL;

ANIMALIA; MAMMALIA; RATTUS;

EID: 36049013693     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rvsc.2007.04.003     Document Type: Article

References (27)

1. Agmo A. Unconditioned sexual incentive motivation in the male Norway rat (Rattus norvegicus). Journal of Comparative Psychology 117 1 (2003) 3-14
2. Agmo A., Paredes R., and Fernandez H. Differential effects of GABA transaminase inhibitors on sexual behavior, locomotion activity, and motor execution in male rat. Pharmacology Biochemistry and Behavior 28 (1987) 47-52
3. Alexander G.E., Crutcher M.D., and DeLong M.R. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, 'prefrontal' and 'limbic' functions. Progress in Brain Research 85 (1990) 119-146
4. Andersen M.L., and Tufik S. Inhibitory effect of GABAergic drugs in cocaine-induced genital reflexes in paradoxical sleep-deprived male rats. Pharmacology Biochemistry and Behavior 78 2 (2004) 301-307
5. Argiolas A., and Melis M.R. Central control of penile erection: role of the paraventricular nucleus of the hypothalamus. Progress in Neurobiology 76 1 (2005) 1-21
6. Bitran D., and Hull E.M. Pharmacological analysis of male rat sexual behavior. Neuroscience and Biobehavioral Reviews 11 (1987) 365-389
7. B agonist in the male rat. Pharmacology Biochemistry and Behavior 31 3 (1988) 657-666
8. Courtney C.H., and Roberson E.L. Chemotherapy of parasitic diseases. In: Adams H.R. (Ed). Veterinary Pharmacology and Therapeutic. seventh ed. (1995), Iowa State University Press, Ames 923-924
9. Dahlgren I.L., Matucszczyk J.V., and Hard E. Sexual orientation in male pregnant rats prenatally exposed to ethanol. Neurotoxicology and Teratology 13 (1991) 267-269
10. Dorfman V.B., Vega M.C., and Coirini H. Age-related changes of the GABA-B receptor in the lumbar spinal cord of male rats and penile erection. Life Science 78 14 (2006) 1529-1534
11. Felício L.F., Flório J.C., Sider L.H., Cruz-Casallas P.E., and Bridges R.S. Reproductive experience increases striatal and hypothalamic dopamine levels in pregnant rats. Brain Research Bulletin 40 (1996) 253-256
12. Fernandez-Guasti A., Larsson K., and Beyer C. Gabaergic control of masculine sexual behavior. Pharmacology Biochemistry and Behavior 24 (1986) 1065-1070
13. Fernandez-Guasti A., Larsson K., and Beyer C. Effect of bicuculline on sexual activity in castrated male rats. Physiology and Behavior 36 (1986) 235-237
14. Fernández-Guasti A., Róldan-Róldan G., and Saldívar A. Pharmacological manipulations of anxiety and male rat sexual behavior. Pharmacology Biochemistry and Behavior 35 (1990) 263-267
15. Groenewegen H.J. The basal ganglia and motor control. Neural Plasticity 10 1-2 (2003) 107-120
16. Gupta C., Shapiro B.H., and Yaffe S.J. Reproductive of dysfunction in male rats following prenatal exposure to Phenobarbital. Pediatric Pharmacology 1 (1980) 55-62
17. Lanusse C., Lifschitz A., Virkel G., Alvarez L., Sánchez S., Sutra J.F., Galtier P., and Alvinerie M. Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle. Journal of Veterinary Pharmacology and Therapeutics 20 2 (1997) 91-99
18. Leipheimer R.E., and Sachs B.D. GABAergic regulation of penile reflexes and copulation in rats. Physiology and Behaviour 42 4 (1988) 351-357
19. Melis M.R., and Argiolas A. Reduction of drug-induced yawning and penile erection and of noncontact erections in male rats by the activation of GABAA receptors in the paraventricular nucleus: involvement of nitric oxide. European Journal of Neuroscience 15 5 (2002) 852-860
20. Melis M.R., Spano M.S., Succu S., and Argiolas A. Activation of gamma-aminobutyric acid (A) receptors in the paraventricular nucleus of the hypothalamus reduces apomorphine-, N-methyl-d-aspartic acid- and oxytocin-induced penile erection and yawning in male rats. Neuroscience Letters 281 2-3 (2000) 127-130
21. Molento M.B., Lifschitz A., Sallovitz J., Lanusse C., and Prichard R. Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep. Parasitology Research 92 2 (2004) 121-127
22. Paredes R.G., and Agmo A. Stereospecific actions of baclofen on sociosexual behavior, locomotor activity and motor execution. Psychopharmacology 97 3 (1989) 358-364
23. Paredes R.G., and Agmo A. The GABAB antagonist CGP 35348 inhibits the effects of baclofen on sexual behavior and motor coordination. Brain Research Bulletin 36 5 (1995) 495-497
24. Rodrigues-Alves, P.S.B., Bernardi, M.M., Spinosa, H.S., in press. Moxidectin interference on motor activity of rats. Brazilian Archives of Biology and Technology.
25. Shoop W.L., Mrozik H., and Fisher M.H. Structure and activity of avermectins and milbemycins in animal health. Veterinary Parasitology 59 (1995) 139-156
26. Silva M.R.P., Oliveira C.A., Felicio L.F., Nasello A.G., and Bernardi M.M. Perinatal treatment with picrotoxin induces sexual, behavioral, and neuroendocrine changes in male rats. Pharmacology Biochemistry and Behavior 60 1 (1998) 203-208
27. Zarrindast M.R., and Farahvash H. Effects of GABA-ergic drugs on penile erection induced by apomorphine in rats. Psychopharmacology (Berlin) 115 1-2 (1994) 249-253