Towards the total synthesis of neurotrophically active tashironins: rapid construction of the tetracyclic core through a tandem oxidative dearomatization-IMDA reaction-RCM protocol

Tetrahedron Letters

Volumn 48, Issue 50, 2007, Pages 8865-8868

  Mehta, Goverdhan ^a   Maity, Pulakesh ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

NATURAL PRODUCT; SESQUITERPENOID; TASHIRONIN DERIVATIVE; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; CHEMICAL BOND; CONFORMATION; CRYSTAL STRUCTURE; CYCLIZATION; CYCLOADDITION; DIASTEREOISOMER; DIELS ALDER REACTION; OXIDATION; QUANTUM YIELD; STEREOCHEMISTRY; SYNTHESIS;

ALNUS;

EID: 36049009146     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.10.052     Document Type: Article

References (18)

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12. Tetrasubstituted aromatic precursor 11 was readily prepared as follows:{A figure is presented}
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15. (2Z,4E)-2-methyl-2,4-hexadienoic acid 12 and (2Z,4E)-2-methyl-2,4-hexadien-1-ol 17 were conveniently prepared as shown below:{A figure is presented}
16. +): 269.1154; found: 269.1154.
17. 2 = 0.1056, GOF = 1.044 for all data. Crystallographic data have been deposited with the Cambridge Crystallographic Data Centre, CCDC-658170.
18. Aromatic precursor 22 was accessed as follows:{A figure is presented}