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Volumn 7, Issue 11, 2007, Pages 1689-1703

T-regulatory lymphocytes and chronic viral hepatitis

Author keywords

FoxP3; Hepatitis B; Hepatitis C; Regulatory T cells; Viral hepatitis

Indexed keywords

HEPATITIS B CORE ANTIBODY;

EID: 36048996837     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.7.11.1689     Document Type: Review
Times cited : (21)

References (95)
  • 1
    • 33646337650 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus
    • CHAN HL, SUNG JJ: Hepatocellular carcinoma and hepatitis B virus. Semin. Liver Dis. (2006) 26:153-161.
    • (2006) Semin. Liver Dis , vol.26 , pp. 153-161
    • CHAN, H.L.1    SUNG, J.J.2
  • 2
    • 0029115078 scopus 로고    scopus 로고
    • KANE M: Global programme for control of hepatitis B infection. Vaccine (1995) (13 Suppl.) 1:S47-S49.
    • KANE M: Global programme for control of hepatitis B infection. Vaccine (1995) (13 Suppl.) 1:S47-S49.
  • 3
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • LEE WM: Hepatitis B virus infection. N Engl. J. Med. (1997) 337:1733-1745.
    • (1997) N Engl. J. Med , vol.337 , pp. 1733-1745
    • LEE, W.M.1
  • 5
    • 0026767691 scopus 로고
    • Lack of protective immunity against reinfection with hepatitis C virus
    • FARCI P, ALTER HJ, GOVINDARAJAN S et al.: Lack of protective immunity against reinfection with hepatitis C virus. Science (1992) 258:135-140.
    • (1992) Science , vol.258 , pp. 135-140
    • FARCI, P.1    ALTER, H.J.2    GOVINDARAJAN, S.3
  • 6
    • 0036715591 scopus 로고    scopus 로고
    • Viruses and interferon: A fight for supremacy
    • KATZE MG, HE Y, GALE M Jr: Viruses and interferon: a fight for supremacy. Nat. Rev. Immunol. (2002) 2:675-687.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 675-687
    • KATZE, M.G.1    HE, Y.2    GALE Jr, M.3
  • 7
    • 33745223509 scopus 로고    scopus 로고
    • Detection of hepatitis C virus (HCV) RNA in the liver of healthy, anti-HCV antibody-positive, serum HCV RNA-negative patients with normal alanine aminotransferase levels
    • CARRENO V, PARDO M, LOPEZ-ALCOROCHO JM, RODRIGUEZ-INIGO E, BARTOLOME J, CASTILLO I: Detection of hepatitis C virus (HCV) RNA in the liver of healthy, anti-HCV antibody-positive, serum HCV RNA-negative patients with normal alanine aminotransferase levels. J. Infect. Dis. (2006) 194:53-60.
    • (2006) J. Infect. Dis , vol.194 , pp. 53-60
    • CARRENO, V.1    PARDO, M.2    LOPEZ-ALCOROCHO, J.M.3    RODRIGUEZ-INIGO, E.4    BARTOLOME, J.5    CASTILLO, I.6
  • 8
    • 33751524309 scopus 로고    scopus 로고
    • Occult hepatitis C virus infection: A new form of hepatitis C
    • CARRENO V: Occult hepatitis C virus infection: a new form of hepatitis C. World J. Gastroenterol. (2006) 12:6922-6925.
    • (2006) World J. Gastroenterol , vol.12 , pp. 6922-6925
    • CARRENO, V.1
  • 9
    • 23944467250 scopus 로고    scopus 로고
    • Adaptive immune responses in acute and chronic hepatitis C virus infection
    • BOWEN DG, WALKER CM: Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature (2005) 436:946-952.
    • (2005) Nature , vol.436 , pp. 946-952
    • BOWEN, D.G.1    WALKER, C.M.2
  • 10
    • 17644444485 scopus 로고    scopus 로고
    • Analysis of successful immune responses in persons infected with hepatitis C virus
    • LECHNER F, WONG DK, DUNBAR PR et al.: Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. (2000) 191:1499-1512.
    • (2000) J. Exp. Med , vol.191 , pp. 1499-1512
    • LECHNER, F.1    WONG, D.K.2    DUNBAR, P.R.3
  • 11
    • 0025245580 scopus 로고
    • Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection
    • FERRARI C, PENNA A, BERTOLETTI A et al.: Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J. Immunol. (1990) 145:3442-3449.
    • (1990) J. Immunol , vol.145 , pp. 3442-3449
    • FERRARI, C.1    PENNA, A.2    BERTOLETTI, A.3
  • 12
    • 0026040543 scopus 로고
    • Hepatitis B virus antigen-specific T-cell activation in patients with acute and chronic hepatitis B
    • JUNG MC, SPENGLER U, SCHRAUT W et al.: Hepatitis B virus antigen-specific T-cell activation in patients with acute and chronic hepatitis B. J. Hepatol. (1991) 13:310-317.
    • (1991) J. Hepatol , vol.13 , pp. 310-317
    • JUNG, M.C.1    SPENGLER, U.2    SCHRAUT, W.3
  • 13
    • 20644471859 scopus 로고    scopus 로고
    • Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B
    • PENNA A, DEL PG, CAVALLI A et al.: Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology (1997) 25:1022-1027.
    • (1997) Hepatology , vol.25 , pp. 1022-1027
    • PENNA, A.1
  • 14
    • 0032754504 scopus 로고    scopus 로고
    • Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection
    • MAINI MK, BONIC, OGG GS et al.: Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection. Gastroenterology (1999) 117:1386-1396.
    • (1999) Gastroenterology , vol.117 , pp. 1386-1396
    • MAINI, M.K.1
  • 15
    • 0025739789 scopus 로고
    • Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen
    • FERRARI C, BERTOLETTI A, PENNA A et al.: Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen. J. Clin. Invest. (1991) 88:214-222.
    • (1991) J. Clin. Invest , vol.88 , pp. 214-222
    • FERRARI, C.1    BERTOLETTI, A.2    PENNA, A.3
  • 16
    • 0025719119 scopus 로고
    • Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen
    • PENNA A, CHISARI FV, BERTOLETTI A et al.: Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen. J. Exp. Med. (1991) 174:1565-1570.
    • (1991) J. Exp. Med , vol.174 , pp. 1565-1570
    • PENNA, A.1    CHISARI, F.V.2    BERTOLETTI, A.3
  • 18
    • 9544232506 scopus 로고    scopus 로고
    • Long-lasting memory T cell responses following self-limited acute hepatitis B
    • PENNA A, ARTINI M, CAVALLI A et al.: Long-lasting memory T cell responses following self-limited acute hepatitis B. J. Clin. Invest. (1996) 98:1185-1194.
    • (1996) J. Clin. Invest , vol.98 , pp. 1185-1194
    • PENNA, A.1    ARTINI, M.2    CAVALLI, A.3
  • 19
    • 0030008076 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection
    • REHERMANN B, LAU D, HOOFNAGLE JH, CHISARI FV: Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection. J. Clin. Invest. (1996) 97:1655-1665.
    • (1996) J. Clin. Invest , vol.97 , pp. 1655-1665
    • REHERMANN, B.1    LAU, D.2    HOOFNAGLE, J.H.3    CHISARI, F.V.4
  • 20
    • 0026040543 scopus 로고
    • Hepatitis B virus antigen-specific T-cell activation in patients with acute and chronic hepatitis B
    • JUNG MC, SPENGLER U, SCHRAUT W et al.: Hepatitis B virus antigen-specific T-cell activation in patients with acute and chronic hepatitis B. J. Hepatol. (1991) 13:310-317.
    • (1991) J. Hepatol , vol.13 , pp. 310-317
    • JUNG, M.C.1    SPENGLER, U.2    SCHRAUT, W.3
  • 21
    • 0345017746 scopus 로고    scopus 로고
    • Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection
    • SUGIMOTO K, IKEDA F, STADANLICK J, NUNES FA, ALTER HJ, CHANG KM: Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology (2003) 38:1437-1448.
    • (2003) Hepatology , vol.38 , pp. 1437-1448
    • SUGIMOTO, K.1    IKEDA, F.2    STADANLICK, J.3    NUNES, F.A.4    ALTER, H.J.5    CHANG, K.M.6
  • 22
    • 0032832514 scopus 로고    scopus 로고
    • Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C
    • GERLACH JT, DIEPOLDER HM, JUNG MC et al.: Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C. Gastroenterology (1999) 117:933-941.
    • (1999) Gastroenterology , vol.117 , pp. 933-941
    • GERLACH, J.T.1    DIEPOLDER, H.M.2    JUNG, M.C.3
  • 23
    • 0029949897 scopus 로고    scopus 로고
    • Immunoregulatory cytokines in chronic hepatitis C virus infection: Pre- and posttreatment with interferon α
    • CACCIARELLI TV, MARTINEZ OM, GISH RG, VILLANUEVA JC, KRAMS SM: Immunoregulatory cytokines in chronic hepatitis C virus infection: pre- and posttreatment with interferon α. Hepatology (1996) 24:6-9.
    • (1996) Hepatology , vol.24 , pp. 6-9
    • CACCIARELLI, T.V.1    MARTINEZ, O.M.2    GISH, R.G.3    VILLANUEVA, J.C.4    KRAMS, S.M.5
  • 24
    • 0031026553 scopus 로고    scopus 로고
    • Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity
    • TSAI SL, LIAW YF, CHEN MH, HUANG CY, KUO GC: Detection of type 2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicity. Hepatology (1997) 25:449-458.
    • (1997) Hepatology , vol.25 , pp. 449-458
    • TSAI, S.L.1    LIAW, Y.F.2    CHEN, M.H.3    HUANG, C.Y.4    KUO, G.C.5
  • 26
    • 0029075716 scopus 로고
    • Characterization of self-reactive T cells that evade tolerance in hepatitis B e antigen transgenic mice
    • MILICH DR, SCHODEL F, PETERSON DL, JONES JE, HUGHES JL: Characterization of self-reactive T cells that evade tolerance in hepatitis B e antigen transgenic mice. Eur. J. Immunol. (1995) 25:1663-1672.
    • (1995) Eur. J. Immunol , vol.25 , pp. 1663-1672
    • MILICH, D.R.1    SCHODEL, F.2    PETERSON, D.L.3    JONES, J.E.4    HUGHES, J.L.5
  • 27
    • 1842375707 scopus 로고    scopus 로고
    • The hepatitis B virus core and e antigens elicit different Th cell subsets: Antigen structure can affect Th cell phenotype
    • MILICH DR, SCHODEL F, HUGHES JL, JONES JE, PETERSON DL: The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype. J. Virol. (1997) 71:2192-2201.
    • (1997) J. Virol , vol.71 , pp. 2192-2201
    • MILICH, D.R.1    SCHODEL, F.2    HUGHES, J.L.3    JONES, J.E.4    PETERSON, D.L.5
  • 28
    • 0032519919 scopus 로고    scopus 로고
    • The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: A mechanism for persistence
    • MILICH DR, CHEN MK, HUGHES JL, JONES JE: The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: a mechanism for persistence. J. Immunol. (1998) 160:2013-2021.
    • (1998) J. Immunol , vol.160 , pp. 2013-2021
    • MILICH, D.R.1    CHEN, M.K.2    HUGHES, J.L.3    JONES, J.E.4
  • 29
    • 0033120555 scopus 로고    scopus 로고
    • Mutations in immunodominant T cell epitopes derived from the nonstructural 3 protein of hepatitis C virus have the potential for generating escape variants that may have important consequences for T cell recognition
    • WANG H, ECKELS DD: Mutations in immunodominant T cell epitopes derived from the nonstructural 3 protein of hepatitis C virus have the potential for generating escape variants that may have important consequences for T cell recognition. J. Immunol. (1999) 162:4177-4183.
    • (1999) J. Immunol , vol.162 , pp. 4177-4183
    • WANG, H.1    ECKELS, D.D.2
  • 31
    • 0032858567 scopus 로고    scopus 로고
    • Association of multispecific CD4(+) response to hepatitis C and severity of recurrence after liver transplantation
    • ROSEN HR, HINRICHS DJ, GRETCH DR et al.: Association of multispecific CD4(+) response to hepatitis C and severity of recurrence after liver transplantation. Gastroenterology (1999) 117:926-932.
    • (1999) Gastroenterology , vol.117 , pp. 926-932
    • ROSEN, H.R.1    HINRICHS, D.J.2    GRETCH, D.R.3
  • 32
    • 0029558878 scopus 로고
    • Infection of circulating and liver infiltrating T cells by hepatitis C virus of different subtypes
    • ARTINI M, NISINI R, MISSALE G et al.: Infection of circulating and liver infiltrating T cells by hepatitis C virus of different subtypes. Viral Immunol. (1995) 8:63-73.
    • (1995) Viral Immunol , vol.8 , pp. 63-73
    • ARTINI, M.1    NISINI, R.2    MISSALE, G.3
  • 33
    • 0030946207 scopus 로고    scopus 로고
    • In-situ immunophenotyping study of hepatic-infiltrating cytotoxic cells in chronic active hepatitis C
    • FIORE G, ANGARANO I, CACCETTA L et al.: In-situ immunophenotyping study of hepatic-infiltrating cytotoxic cells in chronic active hepatitis C. Eur. J. Gastroenterol. Hepatol. (1997) 9:491-496.
    • (1997) Eur. J. Gastroenterol. Hepatol , vol.9 , pp. 491-496
    • FIORE, G.1    ANGARANO, I.2    CACCETTA, L.3
  • 34
    • 0027319205 scopus 로고
    • + T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C
    • + T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C. J. Exp. Med. (1993) 178:17-25.
    • (1993) J. Exp. Med , vol.178 , pp. 17-25
    • MINUTELLO, M.A.1    PILERI, P.2    UNUTMAZ, D.3
  • 35
    • 0036727325 scopus 로고    scopus 로고
    • The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection
    • BARNES E, HARCOURT G, BROWN D, LUCAS M, PHILLIPS R, DUSHEIKO G, KLENERMAN P: The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection. Hepatology (2002) 36:743-754.
    • (2002) Hepatology , vol.36 , pp. 743-754
    • BARNES, E.1    HARCOURT, G.2    BROWN, D.3    LUCAS, M.4    PHILLIPS, R.5    DUSHEIKO, G.6    KLENERMAN, P.7
  • 36
    • 0037198749 scopus 로고    scopus 로고
    • Chronic hepatitis B
    • LOK AS: Chronic hepatitis B. N Engl. J. Med. (2002) 346:1682-1683.
    • (2002) N Engl. J. Med , vol.346 , pp. 1682-1683
    • LOK, A.S.1
  • 37
    • 0032169470 scopus 로고    scopus 로고
    • Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B
    • BONI C, BERTOLETTI A, PENNA A et al.: Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. J. Clin. Invest. (1998) 102:968-975.
    • (1998) J. Clin. Invest , vol.102 , pp. 968-975
    • BONI, C.1    BERTOLETTI, A.2    PENNA, A.3
  • 38
    • 0029957570 scopus 로고    scopus 로고
    • Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection
    • MARINOS G, NAOUMOV NV, WILLIAMS R: Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection. Hepatology (1996) 24:991-995.
    • (1996) Hepatology , vol.24 , pp. 991-995
    • MARINOS, G.1    NAOUMOV, N.V.2    WILLIAMS, R.3
  • 39
    • 17644444485 scopus 로고    scopus 로고
    • Analysis of successful immune responses in persons infected with hepatitis C virus
    • LECHNER F, WONG DK, DUNBAR PR et al.: Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. (2000) 191:1499-1512.
    • (2000) J. Exp. Med , vol.191 , pp. 1499-1512
    • LECHNER, F.1    WONG, D.K.2    DUNBAR, P.R.3
  • 40
    • 17644444485 scopus 로고    scopus 로고
    • Analysis of successful immune responses in persons infected with hepatitis C virus
    • LECHNER F, WONG DK, DUNBAR PR et al.: Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. (2000) 191:1499-1512.
    • (2000) J. Exp. Med , vol.191 , pp. 1499-1512
    • LECHNER, F.1    WONG, D.K.2    DUNBAR, P.R.3
  • 41
    • 2442682870 scopus 로고    scopus 로고
    • + T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy
    • + T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J. Virol. (2004) 78:5707-5719.
    • (2004) J. Virol , vol.78 , pp. 5707-5719
    • WEBSTER, G.J.1    REIGNAT, S.2    BROWN, D.3
  • 42
    • 0037029652 scopus 로고    scopus 로고
    • Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection
    • REIGNAT S, WEBSTER GJ, BROWN D et al.: Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. J. Exp. Med. (2002) 195:1089-1101.
    • (2002) J. Exp. Med , vol.195 , pp. 1089-1101
    • REIGNAT, S.1    WEBSTER, G.J.2    BROWN, D.3
  • 43
    • 12444252951 scopus 로고    scopus 로고
    • Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B
    • BONI C, PENNA A, BERTOLETTI A et al.: Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B. J. Hepatol. (2003) 39:595-605.
    • (2003) J. Hepatol , vol.39 , pp. 595-605
    • BONI, C.1    PENNA, A.2    BERTOLETTI, A.3
  • 44
    • 0032754504 scopus 로고    scopus 로고
    • Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection
    • MAINI MK, BONI C, OGG GS et al.: Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection. Gastroenterology (1999) 117:1386-1396.
    • (1999) Gastroenterology , vol.117 , pp. 1386-1396
    • MAINI, M.K.1    BONI, C.2    OGG, G.S.3
  • 45
    • 0033754682 scopus 로고    scopus 로고
    • Incubation phase of acute hepatitis B in man: Dynamic of cellular immune mechanisms
    • WEBSTER GJ, REIGNAT S, MAINI MK et al.: Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology (2000) 32:1117-1124.
    • (2000) Hepatology , vol.32 , pp. 1117-1124
    • WEBSTER, G.J.1    REIGNAT, S.2    MAINI, M.K.3
  • 46
    • 0034678435 scopus 로고    scopus 로고
    • The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection
    • MAINI MK, BONI C, LEE CK et al.: The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J. Exp. Med. (2000) 191:1269-1280.
    • (2000) J. Exp. Med , vol.191 , pp. 1269-1280
    • MAINI, M.K.1    BONI, C.2    LEE, C.K.3
  • 47
    • 0036109159 scopus 로고    scopus 로고
    • + T cells vary in differentiation phenotype in different persistent virus infections
    • + T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. (2002) 8:379-385.
    • (2002) Nat. Med , vol.8 , pp. 379-385
    • APPAY, V.1    DUNBAR, P.R.2    CALLAN, M.3
  • 49
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • BARBER DL, WHERRY EJ, MASOPUST D et al.: Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2006) 439:682-687.
    • (2006) Nature , vol.439 , pp. 682-687
    • BARBER, D.L.1    WHERRY, E.J.2    MASOPUST, D.3
  • 50
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • DAY CL, KAUFMANN DE, KIEPIELA P et al.: PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature (2006) 443:350-354.
    • (2006) Nature , vol.443 , pp. 350-354
    • DAY, C.L.1    KAUFMANN, D.E.2    KIEPIELA, P.3
  • 51
    • 33947421722 scopus 로고    scopus 로고
    • PENNAA, PILLIM, ZERBINIA et al.: Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology (2007) 45:588-601.
    • PENNAA, PILLIM, ZERBINIA et al.: Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology (2007) 45:588-601.
  • 52
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • BARBER DL, WHERRY EJ, MASOPUST D et al.: Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2006) 439:682-687.
    • (2006) Nature , vol.439 , pp. 682-687
    • BARBER, D.L.1    WHERRY, E.J.2    MASOPUST, D.3
  • 53
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • DAY CL, KAUFMANN DE, KIEPIELA P et al.: PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature (2006) 443:350-354.
    • (2006) Nature , vol.443 , pp. 350-354
    • DAY, C.L.1    KAUFMANN, D.E.2    KIEPIELA, P.3
  • 54
    • 33750691709 scopus 로고    scopus 로고
    • PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
    • URBANI S, AMADEI B, TOLA D et al.: PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J. Virol. (2006) 80:11398-11403.
    • (2006) J. Virol , vol.80 , pp. 11398-11403
    • URBANI, S.1    AMADEI, B.2    TOLA, D.3
  • 55
    • 19944366276 scopus 로고    scopus 로고
    • + cells in HCV-positive livers.
    • + cells in HCV-positive livers.
  • 56
    • 0014667395 scopus 로고
    • Thymus and reproduction: Sex-linked dysgenesia of the gonad after neonatal thymectomy in mice
    • NISHIZUKA Y, SAKAKURA T: Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science (1969) 166:753-755.
    • (1969) Science , vol.166 , pp. 753-755
    • NISHIZUKA, Y.1    SAKAKURA, T.2
  • 57
    • 0017076014 scopus 로고
    • Spontaneous development of autoimmune thyroiditis in neonatally thymectomized mice
    • KOJIMA A, TANAKA-KOJIMA Y, SAKAKURA T, NISHIZUKA Y: Spontaneous development of autoimmune thyroiditis in neonatally thymectomized mice. Lab. Invest. (1976) 34:550-557.
    • (1976) Lab. Invest , vol.34 , pp. 550-557
    • KOJIMA, A.1    TANAKA-KOJIMA, Y.2    SAKAKURA, T.3    NISHIZUKA, Y.4
  • 58
    • 0018865212 scopus 로고
    • Experimental production of possible autoimmune gastritis followed by macrocytic anemia in athymic nude mice
    • KOJIMA A, TAGUCHI O, NISHIZUKA Y: Experimental production of possible autoimmune gastritis followed by macrocytic anemia in athymic nude mice. Lab. Invest. (1980) 42:387-395.
    • (1980) Lab. Invest , vol.42 , pp. 387-395
    • KOJIMA, A.1    TAGUCHI, O.2    NISHIZUKA, Y.3
  • 59
    • 0020451946 scopus 로고
    • Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis
    • SAKAGUCHI S, TAKAHASHI T, NISHIZUKA Y: Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J. Exp. Med. (1982) 156:1577-1586.
    • (1982) J. Exp. Med , vol.156 , pp. 1577-1586
    • SAKAGUCHI, S.1    TAKAHASHI, T.2    NISHIZUKA, Y.3
  • 60
    • 0020432846 scopus 로고
    • Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer
    • SAKAGUCHI S, TAKAHASHI T, NISHIZUKA Y: Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer. J. Exp. Med. (1982) 156:1565-1576.
    • (1982) J. Exp. Med , vol.156 , pp. 1565-1576
    • SAKAGUCHI, S.1    TAKAHASHI, T.2    NISHIZUKA, Y.3
  • 63
    • 0025572276 scopus 로고
    • + T cells induce wasting disease with multiple organ pathology: Prevention by the OX-22low subset
    • + T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset. J. Exp. Med. (1990) 172:1701-1708.
    • (1990) J. Exp. Med , vol.172 , pp. 1701-1708
    • POWRIE, F.1    MASON, D.2
  • 64
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • SAKAGUCHI S, SAKAGUCHI N, ASANO M, ITOH M, TODA M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. (1995) 155:1151-1164.
    • (1995) J. Immunol , vol.155 , pp. 1151-1164
    • SAKAGUCHI, S.1    SAKAGUCHI, N.2    ASANO, M.3    ITOH, M.4    TODA, M.5
  • 65
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • ASANO M, TODA M, SAKAGUCHI N, SAKAGUCHI S: Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. (1996) 184:387-396.
    • (1996) J. Exp. Med , vol.184 , pp. 387-396
    • ASANO, M.1    TODA, M.2    SAKAGUCHI, N.3    SAKAGUCHI, S.4
  • 66
    • 0031939403 scopus 로고    scopus 로고
    • + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
    • + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. (1998) 160:1212-1218.
    • (1998) J. Immunol , vol.160 , pp. 1212-1218
    • SURI-PAYER, E.1    AMAR, A.Z.2    THORNTON, A.M.3    SHEVACH, E.M.4
  • 67
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. (1998) 188:287-296.
    • (1998) J. Exp. Med , vol.188 , pp. 287-296
    • THORNTON, A.M.1    SHEVACH, E.M.2
  • 68
    • 0035525739 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) cells: A naturally occurring population of regulatory T cells
    • NG WF, DUGGAN PJ, PONCHEL F et al.: Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood (2001) 98:2736-2744.
    • (2001) Blood , vol.98 , pp. 2736-2744
    • WF, N.G.1    DUGGAN, P.J.2    PONCHEL, F.3
  • 69
    • 0035806244 scopus 로고    scopus 로고
    • Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood
    • DIECKMANN D, PLOTTNER H, BERCHTOLD S, BERGER T, SCHULER G: Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J. Exp. Med. (2001) 193:1303-1310.
    • (2001) J. Exp. Med , vol.193 , pp. 1303-1310
    • DIECKMANN, D.1    PLOTTNER, H.2    BERCHTOLD, S.3    BERGER, T.4    SCHULER, G.5
  • 70
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    • JONULEIT H, SCHMITT E, STASSEN M, TUETTENBERG A, KNOP J, ENK AH: Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. (2001) 193:1285-1294.
    • (2001) J. Exp. Med , vol.193 , pp. 1285-1294
    • JONULEIT, H.1    SCHMITT, E.2    STASSEN, M.3    TUETTENBERG, A.4    KNOP, J.5    ENK, A.H.6
  • 71
    • 0035062581 scopus 로고    scopus 로고
    • Human anergic/suppressive CD4(+)CD25(+) T cells: A highly differentiated and apoptosis-prone population
    • TAAMS LS, SMITH J, RUSTIN MH, SALMON M, POULTER LW, AKBAR AN: Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population. Eur. J. Immunol. (2001) 31:1122-1131.
    • (2001) Eur. J. Immunol , vol.31 , pp. 1122-1131
    • TAAMS, L.S.1    SMITH, J.2    RUSTIN, M.H.3    SALMON, M.4    POULTER, L.W.5    AKBAR, A.N.6
  • 72
    • 0035806323 scopus 로고    scopus 로고
    • Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • LEVINGS MK, SANGREGORIO R, RONCAROLO MG: Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. (2001) 193:1295-1302.
    • (2001) J. Exp. Med , vol.193 , pp. 1295-1302
    • LEVINGS, M.K.1    SANGREGORIO, R.2    RONCAROLO, M.G.3
  • 74
    • 0037026003 scopus 로고    scopus 로고
    • Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    • ANNUNZIATO F, COSMI L, LIOTTA F et al.: Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J. Exp. Med. (2002) 196:379-387.
    • (2002) J. Exp. Med , vol.196 , pp. 379-387
    • ANNUNZIATO, F.1    COSMI, L.2    LIOTTA, F.3
  • 75
    • 0035054606 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro
    • STEPHENS LA, MOTTET C, MASON D, POWRIE F: Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. (2001) 31:1247-1254.
    • (2001) Eur. J. Immunol , vol.31 , pp. 1247-1254
    • STEPHENS, L.A.1    MOTTET, C.2    MASON, D.3    POWRIE, F.4
  • 78
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • TAKAHASHI T, TAGAMI T, YAMAZAKI S et al.: Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. (2000) 192:303-310.
    • (2000) J. Exp. Med , vol.192 , pp. 303-310
    • TAKAHASHI, T.1    TAGAMI, T.2    YAMAZAKI, S.3
  • 79
    • 0030704726 scopus 로고    scopus 로고
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 389:737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • GROUX, H.1    O'GARRA, A.2    BIGLER, M.3
  • 80
    • 0034077559 scopus 로고    scopus 로고
    • + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
    • + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur. J. Immunol. (2000) 30:1538-1543.
    • (2000) Eur. J. Immunol , vol.30 , pp. 1538-1543
    • CEDERBOM, L.1    HALL, H.2    IVARS, F.3
  • 82
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. (2000) 192:295-302.
    • (2000) J. Exp. Med , vol.192 , pp. 295-302
    • READ, S.1    MALMSTROM, V.2    POWRIE, F.3
  • 85
    • 0037391766 scopus 로고    scopus 로고
    • + T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production
    • + T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production. J. Allergy Clin. Immunol. (2003) 111:862-868.
    • (2003) J. Allergy Clin. Immunol , vol.111 , pp. 862-868
    • BELLINGHAUSEN, I.1    KLOSTERMANN, B.2    KNOP, J.3    SALOGA, J.4
  • 86
    • 11144354531 scopus 로고    scopus 로고
    • + regulatory thymocytes because of their responsiveness to different cytokines
    • + regulatory thymocytes because of their responsiveness to different cytokines. Blood (2004) 103:3117-3121.
    • (2004) Blood , vol.103 , pp. 3117-3121
    • COSMI, L.1    LIOTTA, F.2    ANGELI, R.3
  • 87
    • 0037099733 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells
    • DIECKMANN D, BRUETT CH, PLOETTNER H, LUTZ MB, SCHULER G: Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J. Exp. Med. (2002) 196:247-253.
    • (2002) J. Exp. Med , vol.196 , pp. 247-253
    • DIECKMANN, D.1    BRUETT, C.H.2    PLOETTNER, H.3    LUTZ, M.B.4    SCHULER, G.5
  • 88
    • 0037099719 scopus 로고    scopus 로고
    • Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    • JONULEIT H, SCHMITT E, KAKIRMAN H, STASSEN M, KNOP J, ENK AH: Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J. Exp. Med. (2002) 196:255-260.
    • (2002) J. Exp. Med , vol.196 , pp. 255-260
    • JONULEIT, H.1    SCHMITT, E.2    KAKIRMAN, H.3    STASSEN, M.4    KNOP, J.5    ENK, A.H.6
  • 90
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • HORI S, NOMURA T, SAKAGUCHI S: Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • HORI, S.1    NOMURA, T.2    SAKAGUCHI, S.3
  • 91
    • 0038434099 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
    • GAMBINERI E, TORGERSON TR, OCHS HD: Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr. Opin. Rheumatol. (2003) 15:430-435.
    • (2003) Curr. Opin. Rheumatol , vol.15 , pp. 430-435
    • GAMBINERI, E.1    TORGERSON, T.R.2    OCHS, H.D.3
  • 92
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-{κ}B to repress cytokine gene expression and effector functions of T helper cells
    • BETTELLI E, DASTRANGE M, OUKKA M: Foxp3 interacts with nuclear factor of activated T cells and NF-{κ}B to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. USA (2005) 102:5138-5143.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5138-5143
    • BETTELLI, E.1    DASTRANGE, M.2    OUKKA, M.3
  • 93
    • 0348223787 scopus 로고    scopus 로고
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. (2003) 198:1875-1886.
    • (2003) J. Exp. Med , vol.198 , pp. 1875-1886
    • CHEN, W.1    JIN, W.2    HARDEGEN, N.3


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