Single-center experience on liver transplantation for hepatocellular carcinoma arising in alcoholic cirrhosis: Results and ethical issues

European Surgical Research

Volumn 40, Issue 1, 2008, Pages 7-13

  Sotiropoulos, G C ^a   Beckebaum, S ^a   Lang, H ^a   Frilling, A ^a   Molmenti, E P ^a   Cicinnati, V R ^a   Saner, F H ^a   Erim, Y ^a   Baba, H A ^a   Malago M ^a   Broelsch, C E ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Abstinence; Alcoholic cirrhosis; Alcoholic liver disease; Alcoholism; Hepatocellular carcinoma; Liver transplantation; Milan criteria; Recidivism; Tumor recurrence

Indexed keywords

ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; ANALYTIC METHOD; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HUMAN; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; MALE; MEDICAL ETHICS; ORGAN DONOR; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; QUALITY OF LIFE;

AGED; CARCINOMA, HEPATOCELLULAR; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LIVER CIRRHOSIS, ALCOHOLIC; LIVER NEOPLASMS; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; QUALITY OF LIFE; RECURRENCE;

EID: 36048993727     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000107615     Document Type: Article

References (34)

1. Lim JK, Keeffe EB: Liver transplantation for alcoholic liver disease: current concepts and length of sobriety. Liver Transpl 2004;10:S31-S38.
2. Mackie J, Groves K, Hoyle A, Garcia C, Garcia R, Gunson B, Neuberger J: Orthotopic liver transplantation for alcoholic liver disease: a retrospective analysis of survival, recidivism, and risk factors predisposing to recidivism. Liver Transpl 2001;7:418-427.
3. Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, Montalto F, Ammatuna M, Morabito A, Gennari L: Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996;334:693-699.
4. Bismuth H, Majno PE, Adam R: Liver transplantation for hepatocellular carcinoma. Semin Liver Dis 1999;19:311-322.
5. De Carlis L, Giacomoni A, Lauterio A, Slim A, Sammartino C, Pirotta V, Colella G, Forti D: Liver transplantation for hepatocellular cancer: should the current indication criteria be changed? Transpl Int 2003;16:115-122.
6. Greene FL, Page DL, Fleming ID, et al: AJCC Cancer Staging Manual, ed 6. New York, Springer, 2002, pp 131.
7. Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M, Rodes J; EASL Panel of Experts on HCC: Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 2001;35:421-430.
8. Yokoyama I, Todo S, Iwatsuki S, Starzl TE: Liver transplantation in the treatment of primary liver cancer. Hepatogastroenterology 1990;37:188-193.
9. Bismuth H, Chiche L, Adam R, Castaing D, Diamond T, Dennison A: Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg 1993;218:145-151.
10. Ojogho ON, So SK, Keeffe EB, Berquist W, Concepcion W, Garcia-Kennedy R, Imperial J, Esquivel CO: Orthotopic liver transplantation for hepatocellular carcinoma: Factors affecting long-term patient survival. Arch Surg 1996;131:935-939.
11. Michel J, Suc B, Fourtanier G, Durand D, Rumeau JL, Rostaing L, Lloveras JJ: Recurrence of hepatocellular carcinoma in cirrhotic patients after liver resection or transplantation. Transplant Proc 1995;27:1798-1800.
12. Llovet JM, Bruix J, Fuster J, Castells A, Garcia-Valdecasas JC, Grande L, Franca A, Bru C, Navasa M, Ayuso MC, Sole M, Real MI, Vilana R, Rimola A, Visa J, Rodes J: Liver transplantation for small hepatocellular carcinoma: The tumor-node-metastasis classification does not have prognostic power. Hepatology 1998;27:1572-1577.
13. Yamamoto J, Iwatsuki S, Kosuge T, Dvorchik I, Shimada K, Marsh JW, Yamasaki S, Starzl TE: Should hepatomas be treated with hepatic resection or transplantation? Cancer 1999;86:1151-1158.
14. Hemming AW, Cattral MS, Reed AI, Van Der Werf WJ, Greig PD, Howard RJ: Liver transplantation for hepatocellular carcinoma. Ann Surg 2001;233:652-659.
15. Yao FY, Ferrell L, Bass NM, Watson JJ, Bacchetti P, Venook A, Ascher NL, Roberts JP: Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology 2001;33:1394-1403.
16. Herrero JI, Sangro B, Quiroga J, Pardo F, Herraiz M, Cienfuegos JA, Prieto J: Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma. Liver Transpl 2001;7:631-636.
17. Margarit C, Charco R, Hidalgo E, Allende H, Castells L, Bilbao I: Liver transplantation for malignant diseases: Selection and pattern of recurrence. World J Surg 2002;26:257-263.
18. Bigourdan JM, Jaeck D, Meyer N, Meyer C, Oussoultzoglou E, Bachellier P, Weber JC, Audet M, Doffoel M, Wolf P: Small hepatocellular carcinoma in Child A cirrhotic patients: hepatic resection versus transplantation. Liver Transpl 2003;9:513-520.
19. Kaihara S, Kiuchi T, Ueda M, Oike F, Fujimoto Y, Ogawa K, Kozaki K, Tanaka K: Living-donor liver transplantation for hepatocellular carcinoma. Transplantation 2003;75:S37-S40.
20. Cillo U, Vitale A, Bassanello M, Boccagni P, Brolese A, Zanus G, Burra P, Fagiuoli S, Farinati F, Rugge M, D'Amico DF: Liver transplantation for the treatment of moderately or well-differentiated hepatocellular carcinoma. Ann Surg 2004;239:150-159.
21. Roayaie S, Schwartz JD, Sung MW, Emre SH, Miller CM, Gondolesi GE, Krieger NR, Schwartz ME: Recurrence of hepatocellular carcinoma after liver transplant: patterns and prognosis. Liver Transpl 2004;10:534-540.
22. Shetty K, Timmins K, Brensinger C, Furth EE, Rattan S, Sun W, Rosen M, Soulen M, Shaked A, Reddy KR, Olthoff KM: Liver transplantation for hepatocellular carcinoma validation of present selection criteria in predicting outcome. Liver Transpl 2004;10:911-918.
23. Zavaglia C, De Carlis L, Alberti AB, Minola E, Belli LS, Slim AO, Airoldi A, Giacomoni A, Rondinara G, Tinelli C, Forti D, Pinzello G: Predictors of long-term survival after liver transplantation for hepatocellular carcinoma. Am J Gastroenterol 2005;100:2708-2716.
24. Löhe F, Angele MK, Gerbes AL, Lohrs U, Jauch KW, Schauer RJ: Tumour size is an important predictor for the outcome after livertransplantation for hepatocellular carcinoma. Eur J Surg Oncol 2005;31:994-999.
25. Yamanaka T, Shiraki K, Nakazaawa S, Okano H, Ito T, Deguchi M, Takase K, Nakano T: Impact of hepatitis B and C virus infection on the clinical prognosis of alcoholic liver cirrhosis. Anticancer Res 2001;21:2937-2940.
26. Uetake S, Yamauchi M, Itoh S, Kawashima O, Takeda K, Ohata M: Analysis of risk factors for hepatocellular carcinoma in patients with HBs antigen- and anti-HCV antibody-negative alcoholic cirrhosis: clinical significance of prior hepatitis B virus infection. Alcohol Clin Exp Res 2003;27:S47-S51.
27. Gondolesi GE, Roayaie S, Munoz L, Kim-Schluger L, Schiano T, Fishbein TM, Emre S, Miller CM, Schwartz ME: Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria. Ann Surg 2004;239:142-149.
28. Malago M, Sotiropoulos GC, Nadalin S, Valentin-Gamazo C, Paul A, Lang H, Radtke A, Saner F, Molmenti E, Beckebaum S, Gerken G, Frilling A, Broelsch CE: Living donor liver transplantation for hepatocellular carcinoma: a single-center preliminary report. Liver Transpl 2006;12:934-940.
29. Berlakovich GA: Wasting your organ with your lifestyle and receiving a new one? Ann Transplant 2005;10:38-43.
30. Longworth L, Young T, Buxton MJ, Ratcliffe J, Neuberger J, Burroughs A, Bryan S;CELT Project Team: Midterm cost-effectiveness of the liver transplantation program of England and Wales for three disease groups. Liver Transpl 2003;9:1295-1307.
31. Burra P, Mioni D, Cillo U, Fagiuoli S, Senzolo M, Naccarato R, Martines D: Long-term medical and psycho-social evaluation of patients undergoing orthotopic liver transplantation for alcoholic liver disease. Transpl Int 2000;13:S174-S178.
32. Jauhar S, Talwalkar JA, Schneekloth T, Jowsey S, Wiesner RH, Menon KV: Analysis of factors that predict alcohol relapse following liver transplantation. Liver Transpl 2004;10:408-411.
33. Bramstedt KA, Stowe J, Lemberg B: The dilemma of alcohol use by potential living liver donors. Prog Transplant 2006;16:24-27.
34. Jain A, DiMartini A, Kashyap R, Youk A, Rohal S, Fung J: Long-term follow-up after liver transplantation for alcoholic liver disease under tacrolimus. Transplantation 2000;70:1335-1342.