Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 27, Issue 11, 2007, Pages 2348-2354

  Fulop, Tibor ^a   Jebelovszki, Eva ^b   Erdei, Nora ^a   Szerafin, Tamas ^a   Forster, Tamas ^b   Edes, Istvan ^a   Koller, Akos ^c   Bagi, Zsolt ^a,c  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Coronary microcirculation; Flow mediated dilation; Hypertension; Nitrate; Obesity

Indexed keywords

BRADYKININ; GLYCERYL TRINITRATE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; VASODILATOR AGENT;

ADAPTATION; ADULT; AGONIST; ARTERIOLE; ARTERY BLOOD FLOW; ARTICLE; BODY MASS; BRACHIAL ARTERY; CARDIAC PATIENT; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORRELATION ANALYSIS; FEMALE; HEART SURGERY; HUMAN; HYPERTENSION; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; MICROCIRCULATION; OBESITY; PRIORITY JOURNAL; SURGICAL PATIENT; VASODILATATION; VASOMOTOR REFLEX; AGED; CORONARY BLOOD VESSEL; DRUG EFFECT; ECHOGRAPHY; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGED; ARTERIOLES; BODY MASS INDEX; BRACHIAL ARTERY; BRADYKININ; CORONARY VESSELS; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NITROGLYCERIN; NITROPRUSSIDE; OBESITY; VASODILATION; VASODILATOR AGENTS;

EID: 36048987956     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.107.147991     Document Type: Article

References (28)

1. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 2002;288:1723-1727.
2. Davy KP, Hall JE. Obesity and hypertension: two epidemics or one? Am J Physiol Regul Integr Comp Physiol. 2004;286:R803-R813.
3. Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol. 2006;26:968-976.
4. Haffner S, Taegtmeyer H. Epidemic obesity and the metabolic syndrome. Circulation. 2003;108:1541-1545.
5. Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315:1046-1051.
6. Zeiher AM, Drexler H, Wollschlager H, Just H. Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis. Circulation. 1991;84:1984-1992.
7. Huang A, Koller A. Both nitric oxide and prostaglandin-mediated responses are impaired in skeletal muscle arterioles of hypertensive rats. J Hypertens. 1996;14:887-895.
8. Huang A, Sun D, Smith CJ, Connetta JA, Shesely EG, Koller A, Kaley G. In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF. Am J Physiol Heart Circ Physiol. 2000;278:H762-H768.
9. Koller A. Signaling pathways of mechanotransduction in arteriolar endothelium and smooth muscle cells in hypertension. Microcirculation. 2002;9:277-294.
10. Ungvari Z, Csiszar A, Kaminski PM, Wolin MS, Koller A. Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin system. Am J Pathol. 2004;165:219-226.
11. Ceravolo R, Maio R, Pujia A, Sciacqua A, Ventura G, Costa MC, Sesti G, Perticone F. Pulse pressure and endothelial dysfunction in never-treated hypertensive patients. J Am Coll Cardiol. 2003;41:1753-1758.
12. Palombo C, Kozakova M, Magagna A, Bigalli G, Morizzo C, Ghiadoni L, Virdis A, Emdin M, Taddei S, L'Abbate A, Salvetti A. Early impairment of coronary flow reserve and increase in minimum coronary resistance in borderline hypertensive patients. J Hypertens. 2000;18:453-459.
13. Jarvisalo MJ, Lehtimaki T, Raitakari OT. Determinants of arterial nitrate-mediated dilatation in children: role of oxidized low-density lipoprotein, endothelial function, and carotid intima-media thickness. Circulation. 2004;109:2885-2889.
14. Kapiotis S, Holzer G, Schaller G, Haumer M, Widhalm H, Weghuber D, Jilma B, Roggla G, Wolzt M, Widhalm K, Wagner OF. A proinflammatory state is detectable in obese children and is accompanied by functional and morphological vascular changes. Arterioscler Thromb Vasc Biol. 2006;26:2541-2546.
15. Anderson TJ, Uehata A, Gerhard MD, Meredith IT, Knab S, Delagrange D, Lieberman EH, Ganz P, Creager MA, Yeung AC, Selwyn AP. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 1995;26:1235-1241.
16. Takase B, Uehata A, Akima T, Nagai T, Nishioka T, Hamabe A, Satomura K, Ohsuzu F, Kurita A. Endothelium-dependent flow-mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease. Am J Cardiol. 1998;82:1535-1539.
17. Lavie CJ, Messerli FH. Cardiovascular adaptation to obesity and hypertension. Chest. 1986;90:275-279.
18. Henderson KK, Turk JR, Rush JW, Laughlin MH. Endothelial function in coronary arterioles from pigs with early-stage coronary disease induced by high-fat, high-cholesterol diet: effect of exercise. J Appl Physiol. 2004;97:1159-1168.
19. Prakash R, Mintz JD, Stepp DW. Impact of obesity on coronary microvascular function in the Zucker rat. Microcirculation. 2006;13:389-396.
20. Szerafin T, Erdei N, Fulop T, Pasztor ET, Edes I, Koller A, Bagi Z. Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus. Circ Res. 2006;99:e12-e17.
21. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111-1115.
22. Kovacs I, Toth J, Tarjan J, Koller A. Correlation of flow mediated dilation with inflammatory markers in patients with impaired cardiac function. Beneficial effects of inhibition of ACE. Eur J Heart Fail. 2006;8:451-459.
23. Hashimoto M, Akishita M, Eto M, Kozaki K, Ako J, Sugimoto N, Yoshizumi M, Toba K, Ouchi Y. The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. Int J Obes Relat Metab Disord. 1998;22:477-484.
24. Zhang X, Scicli GA, Xu X, Nasjletti A, Hintze TH. Role of Endothelial Kinins in Control of Coronary Nitric Oxide Production. Hypertension. 1997;30:1105-1111.
25. Kuga MD, Mohri MD, Egashira MD, Hirakawa MD, Tagawa MD, Shimokawa MD, Takeshita MD. Bradykinin-Induced Vasodilation of Human Coronary Arteries In Vivo: Role of Nitric Oxide and Angiotensin-Converting Enzyme. J Am Coll Cardiol. 1997;30:108-112.
26. Lind L, Hall J, Larsson A, Annuk M, Fellstrom B, Lithell H. Evaluation of endothelium-dependent vasodilation in the human peripheral circulation. Clin Physiol. 2000;20:440-448.
27. Lin LY, Lee WJ, Shen HN, Yang WS, Pai NH, Su TC, Liau CS. Nitric oxide production is paradoxically decreased after weight reduction surgery in morbid obesity patients. Atherosclerosis. 2007;190:436-442.
28. Barrett-Connor E, Khaw KT. Is hypertension more benign when associated with obesity? Circulation. 1985;72:53-60.