The role of trastuzumab in early stage breast cancer: Current data and treatment recommendations

Current Treatment Options in Oncology

Volumn 8, Issue 1, 2007, Pages 47-60

  Lin, Amy ^a   Rugo, Hope S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; NAVELBINE; PACLITAXEL; TRASTUZUMAB; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

ANTIANGIOGENIC ACTIVITY; ANXIETY; ARTHRALGIA; ASTHENIA; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RESISTANCE; CANCER STAGING; CANCER SURVIVAL; CARDIOTOXICITY; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; CONSTIPATION; DIARRHEA; DISEASE FREE SURVIVAL; DRUG EFFICACY; DRUG ERUPTION; DRUG HALF LIFE; DRUG POTENTIATION; DRUG WITHDRAWAL; FLU LIKE SYNDROME; HAND FOOT SYNDROME; HEADACHE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; INSOMNIA; LOADING DRUG DOSE; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; MYALGIA; NAUSEA; NEUTROPENIA; OVERALL SURVIVAL; PAIN; PATIENT CARE; PNEUMONIA; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RHINITIS; SENSORY NEUROPATHY; SIDE EFFECT; STOMATITIS; BREAST TUMOR; DRUG INTERACTION; DRUG RESISTANCE; FEMALE; LYMPH NODE METASTASIS; METHODOLOGY; ONCOLOGY; PHENOTYPE; TREATMENT OUTCOME;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CLINICAL TRIALS; DRUG INTERACTIONS; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; LYMPHATIC METASTASIS; MEDICAL ONCOLOGY; PHENOTYPE; TREATMENT OUTCOME;

EID: 36048985668     PISSN: 15272729     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11864-007-0008-2     Document Type: Review

References (43)

1. Society AC (2006) Cancer Facts and Figures 2006. American Cancer Society, Atlanta, GA
2. Ravdin PM, Chamness GC (1995) The c-erbB-2 proto-oncogene as a prognostic and predictive marker in breast cancer: A paradigm for the development of other macromolecular markers - a review. Gene 159:19-27
3. Slamon DJ, Clark G, Wong S, et al (1987) Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/neu Oncogene. Science 235:177-182
4. Romond EH, Perez EA, Bryant J, et al (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 353:1673-1684
5. Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al (2005) Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 353:1659-1672
6. Slamon D, Eiermann W, Robert N, et al (2006) BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients. Breast Cancer Res Treat 100(S1):52
7. Multi-agent chemotherapy for early breast cancer. Cochrane Database Syst Rev:CD000487, 2002.
8. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005, 365:1687-1717.
9. Levine MN, Pritchard KI, Bramwell VH, et al (2005) Randomized trial comparing cyclophosphamide, epirubicin, and fluorouracil with cyclophosphamide, methotrexate, and fluorouracil in premenopausal women with node-positive breast cancer: Update of National Cancer Institute of Canada Clinical Trials Group Trial MA5. J Clin Oncol 23:5166-5170
10. Berry DA, Inoue L, Shen Y, et al.: Modeling the impact of treatment and screening on U.S. breast cancer mortality: A Bayesian approach. J Natl Cancer Inst Monogr 2006, 30-36.
11. Mamounas EP, Bryant J, Lembersky B, et al (2005) Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: Results from NSABP B-28. J Clin Oncol 23:3686-3696
12. Henderson IC, Berry DA, Demetri GD, et al (2003) Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer. J Clin Oncol 21:976-983
13. Slamon DJ, Clark GM, Wong SG, et al (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177-182
14. Paik S, Liu ET (2000) HER2 as a predictor of therapeutic response in breast cancer. Breast Dis 11:91-102
15. Press MF, Jones LA, Godolphin W, et al (1990) HER-2/neu oncogene amplification and expression in breast and ovarian cancers. Prog Clin Biol Res 354A:209-221
16. Carlson RW, Moench SJ, Hammond ME, et al.: HER2 testing in breast cancer: NCCN Task Force report and recommendations. J Natl Compr Canc Netw 2006, 4(Suppl 3):S1-S22; quiz S23-S4.16, 17.
17. Wolff AC, Hammond ME, Schwartz JN, et al (2007) American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 25:118-45
18. Perez EA, Suman VJ, Davidson NE, et al (2006) HER2 testing by local, central, and reference laboratories in specimens from the North Central Cancer Treatment Group N9831 intergroup adjuvant trial. J Clin Oncol 24:3032-3038
19. Wang S, Saboorian MH, Frenkel E, et al (2000) Laboratory assessment of the status of Her-2/neu protein and oncogene in breast cancer specimens: comparison of immunohistochemistry assay with fluorescence in situ hybridisation assays. J Clin Pathol 53:374-381
20. Pauletti G, Dandekar S, Rong H, et al (2000) Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: A direct comparison of fluorescence in situ hybridization and immunohistochemistry. J Clin Oncol 18:3651-3664
21. Vogel CL, Cobleigh MA, Tripathy D, et al (2002) Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20:719-726
22. Slamon DJ, Leyland-Jones B, Shak S, et al (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344:783-792
23. Dybdal N, Leiberman G, Anderson S, et al (2005) Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab. Breast Cancer Res Treat 93:3-11
24. Tokunaga E, Oki E, Nishida K, et al (2006) Trastuzumab and breast cancer: Developments and current status. Int J Clin Oncol 11:199-208
25. Cobleigh MA, Vogel CL, Tripathy D, et al (1999) Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 17:2639-2648
26. Baselga J, Albanell J, Molina MA, et al (2001) Mechanism of action of trastuzumab and scientific update. Semin Oncol 28:4-11
27. Sliwkowski MX, Lofgren JA, Lewis GD, et al (1999) Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). Semin Oncol 26:60-70
28. Albanell J, Codony J, Rovira A, et al (2003) Mechanism of action of anti-HER2 monoclonal antibodies: Scientific update on trastuzumab and 2C4. Adv Exp Med Biol 532:253-268
29. Clynes RA, Towers TL, Presta LG, et al (2000) Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 6:443-446
30. Izumi Y, Xu L, di Tomaso E, et al (2002) Tumour biology: Herceptin acts as an anti-angiogenic cocktail. Nature 416:279-280
31. Baselga J, Carbonell X, Castaneda-Soto NJ, et al (2005) Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 23:2162-2171
32. Pegram MD, Konecny GE, O'Callaghan C, et al (2004) Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer. J Natl Cancer Inst 96:739-749
33. Joensuu H, Kellokumpu-Lehtinen PL, Bono P, et al (2006) Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 354:809-820
34. Perez EA, Rodeheffer R (2004) Clinical cardiac tolerability of trastuzumab. J Clin Oncol 22:322-329
35. Tan-Chiu E, Yothers G, Romond E, et al (2005) Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31. J Clin Oncol 23:7811-7819
36. Crone SA, Zhao YY, Fan L, et al (2002) ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 8:459-465
37. Nahta R, Yuan LX, Zhang B, et al (2005) Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 65:11118-11128
38. Zabrecky JR, Lam T, McKenzie SJ, et al (1991) The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3. J Biol Chem 266:1716-1720
39. Nagata Y, Lan KH, Zhou X, et al (2004) PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6:117-127
40. Pegram MD, Reese DM (2002) Combined biological therapy of breast cancer using monoclonal antibodies directed against HER2/neu protein and vascular endothelial growth factor. Semin Oncol 29:29-37
41. Nahta R, Esteva FJ (2006) HER2 therapy: Molecular mechanisms of trastuzumab resistance. Breast Cancer Res 8:215
42. Geyer C, Cameron D, Lindquist D, et al.: A phase III randomized, open-label, international study comparing lapatinib and capecitabine vs capecitabine in women with refractory advanced or metastatic breast cancer (EGF100151). Presentation at Scientific Special Session, "Lapatinib in Trastuzumab-Resistant Breast Cancer". J Clin Oncol 2006, 24(18S).
43. Pegram M, Chan D, Dichmann RA, et al (2006) Phase II combined biological therapy targeting the HER2 proto-oncogene and the vascular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first line treatment of HER2-amplified breast cancer. Breast Cancer Res Treat 100(S1):301