Zap-70 and CD38 as predictors of IgVH mutation in CLL

Experimental and Molecular Pathology

Volumn 83, Issue 3, 2007, Pages 459-461

  Cruse, Julius M ^a   Lewis, Robert E ^a   Webb, Rachel N ^a   Sanders, Catherine M ^a   Suggs, Jeanann L ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

CD38; CLL; Flow cytometry; Zap 70

Indexed keywords

CD38 ANTIGEN; IMMUNOGLOBULIN; PROTEIN KINASE ZAP 70;

ANTIGEN EXPRESSION; ARTICLE; CANCER PATIENT; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; COMPARATIVE STUDY; GENE MUTATION; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; PREDICTION; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ANTIGENS, CD38; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MEMBRANE GLYCOPROTEINS; MUTATION; PROGNOSIS; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 36048984407     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2007.08.009     Document Type: Article

References (9)

1. Chan A.C., Iwashima M., Turck C.W., and Weiss A. Zap-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 71 (1992) 649-662
2. Crespo M., Bosch F., Villamor N., et al. Zap-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N. Engl. J. Med. 348 (2003) 1764-1775
3. Cruse J.M., Lewis R.E., and Wang H. Immunology Guidebook. (2004), Elsevier Press, San Diego
4. Damle R.N., Wasil T., Fais F., et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94 (1999) 1840-1847
5. Deaglio S., Vaisitti T., Aydin S., Ferrero E., and Malavasi F. In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia. Blood 108 (2006) 1135-1144
6. Hamblin T.J., Davis Z., Gardiner A., Oscier D.G., and Stevenson F.K. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94 (1999) 1848-1854
7. Hamblin T.J., Orchard J.A., Gardiner A., Oscier D.G., Davis Z., and Stevenson F.K. Immunoglobulin V genes and CD38 expression in CLL. Blood 95 (2000) 2455-2457
8. Rozman C., and Montserrat E. Chronic lymphocytic leukemia. N. Engl. J. Med. 333 16 (1995) 1052-1057
9. Shanafelt T.D., Geyer S.M., and Kay N.E. Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL. Blood 103 (2004) 1202-1210