Cutaneous Vascular Disorders Associated with Internal Malignancy

Dermatologic Clinics

Volumn 26, Issue 1, 2008, Pages 45-57

  El Tal, Abdel Kader ^a   Tannous, Zeina ^b,c  

^a OAKWOOD HOSPITAL AND MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOCARCINOMA; ARTERY THROMBOSIS; ARTIFICIAL EMBOLISM; BLOOD VESSEL OCCLUSION; CARCINOID SYNDROME; COLON CANCER; DISEASE ASSOCIATION; DISSEMINATED INTRAVASCULAR CLOTTING; ECCHYMOSIS; ERYTHEMA; FLUSHING; HUMAN; HYPERCOAGULABILITY; IDIOPATHIC THROMBOCYTOPENIC PURPURA; ISCHEMIA; KIDNEY CARCINOMA; LEUKOSTASIS; LUNG CANCER; MALIGNANT NEOPLASTIC DISEASE; MASTOCYTOSIS; PANCREAS CANCER; PANCREAS TUMOR; PARAPROTEINEMIA; PATHOPHYSIOLOGY; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PURPURA; REVIEW; SKIN BLOOD VESSEL DISORDER; SKIN MANIFESTATION; TELANGIECTASIA; THROMBOEMBOLISM; THROMBOPHLEBITIS; THROMBOTIC THROMBOCYTOPENIC PURPURA; THYROID CARCINOMA; VASCULITIS; VASODILATATION; VEIN THROMBOSIS;

ECCHYMOSIS; FLUSHING; HUMANS; ISCHEMIA; NEOPLASMS; PARANEOPLASTIC SYNDROMES; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SKIN; VASCULAR DISEASES;

EID: 36048983807     PISSN: 07338635     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.det.2007.08.001     Document Type: Review

References (113)

1. Feingold K.R., and Elias P.M. Endocrine-skin interactions. Cutaneous manifestations of adrenal disease, pheochromocytomas, carcinoid syndrome, sex hormone excess and deficiency, polyglandular autoimmune syndromes, multiple endocrine neoplasia syndromes, and other miscellaneous disorders. J Am Acad Dermatol 19 1 Pt 1 (1988) 1-20
2. Valent P., Akin C., Sperr W.R., et al. Mast cell proliferative disorders: current view on variants recognized by the World Health Organization. Hematol Oncol Clin North Am 17 5 (2003) 1227-1241
3. Wilkin J.K. Flushing reactions: consequences and mechanisms. Ann Intern Med 95 4 (1981) 468-476
4. Kebebew E., Ituarte P.H., Siperstein A.E., et al. Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems. Cancer 88 5 (2000) 1139-1148
5. Cronin R.E., Kaehny W.D., Miller P.D., et al. Renal cell carcinoma: unusual systemic manifestations. Medicine (Baltimore) 55 4 (1976) 291-311
6. Krejs G.J. VIPoma syndrome. Am J Med 82 5B (1987) 37-48
7. Myers B.M., Miralles G.D., Taylor C.A., et al. POEMS syndrome with idiopathic flushing mimicking carcinoid syndrome. Am J Med 90 5 (1991) 646-648
8. Umeki S., Tamai H., Yagi S., et al. Harlequin syndrome (unilateral flushing and sweating attack) due to a spinal invasion of the left apical lung cancer. [abstract]. Rinsho Shinkeigaku 30 1 (1990) 94-99
9. Mohyi D., Tabassi K., and Simon J. Differential diagnosis of hot flashes. Maturitas 27 3 (1997) 203-214
10. Bell H.K., Poston G.J., Vora J., et al. Cutaneous manifestations of the malignant carcinoid syndrome. Br J Dermatol 152 1 (2005) 71-75
11. Roberts II L.J., Marney Jr. S.R., and Oates J.A. Blockade of the flush associated with metastatic gastric carcinoid by combined histamine H1 and H2 receptor antagonists. Evidence for an important role of H2 receptors in human vasculature. N Engl J Med 300 5 (1979) 236-238
12. Zeitlin I.J., and Smith A.N. 5-hydroxyindoles and kinins in the carcinoid and dumping syndromes. Lancet 2 7471 (1966) 986-991
13. Smith A.G., and Greaves M.W. Blood prostaglandin activity associated with noradrenaline-provoked flush in the carcinoid syndrome. Br J Dermatol 90 5 (1974) 547-551
14. Aldrich L.B., Moattari A.R., and Vinik A.I. Distinguishing features of idiopathic flushing and carcinoid syndrome. Arch Intern Med 148 12 (1988) 2614-2618
15. De Herder W.W. Tumours of the midgut (jejunum, ileum and ascending colon, including carcinoid syndrome). Best Pract Res Clin Gastroenterol 19 5 (2005) 705-715
16. Kaltsas G.A., Besser G.M., and Grossman A.B. The diagnosis and medical management of advanced neuroendocrine tumors. Endocr Rev 25 3 (2004) 458-511
17. van der Lely A.J., and de Herder W.W. Carcinoid syndrome: diagnosis and medical management. Arq Bras Endocrinol Metabol 49 5 (2005) 850-860
18. Tharp M.D. Mastocytosis. In: Bolognia J.L., Jorizzo J.L., and Rapini R.P. (Eds). Dermatology vol. 2 (2003), Mosby, Philadelphia 1899-1906
19. Travis W.D., Li C.Y., Bergstralh E.J., et al. Systemic mast cell disease. Analysis of 58 cases and literature review. Medicine (Baltimore) 67 6 (1988) 345-368
20. Roberts II L.J., Sweetman B.J., Lewis R.A., et al. Increased production of prostaglandin D2 in patients with systemic mastocytosis. N Engl J Med 303 24 (1980) 1400-1404
21. Valent P., Sperr W.R., Schwartz L.B., et al. Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hematopoietic neoplasms. J Allergy Clin Immunol 114 1 (2004) 3-11
22. Escribano L., Akin C., Castells M., et al. Mastocytosis: current concepts in diagnosis and treatment. Ann Hematol 81 12 (2002) 677-690
23. Marone G., Spadaro G., Granata F., et al. Treatment of mastocytosis: pharmacologic basis and current concepts. Leuk Res 25 7 (2001) 583-594
24. Beressi N., Campos J.M., Beressi J.P., et al. Sporadic medullary microcarcinoma of the thyroid: a retrospective analysis of eighty cases. Thyroid 8 11 (1998) 1039-1044
25. Engelman K. Malignant carcinoid syndrome. In: DeGroot L.J. (Ed). Textbook of endocrinology. 3rd edition vol. 3. (1995), Saunders, Philadelphia 2649-2657
26. Massoll N., and Mazzaferri E.L. Diagnosis and management of medullary thyroid carcinoma. Clin Lab Med 24 1 (2004) 49-83
27. Plaksin J., Landau Z., and Coslovsky R. A carcinoid-like syndrome caused by a prostaglandin-secreting renal cell carcinoma. Arch Intern Med 140 8 (1980) 1095-1096
28. Lance J.W., Drummond P.D., Gandevia S.C., et al. Harlequin syndrome: the sudden onset of unilateral flushing and sweating. J Neurol Neurosurg Psychiatr 51 5 (1988) 635-642
29. Moon S.Y., Shin D.I., Park S.H., et al. Harlequin syndrome with crossed sympathetic deficit of the face and arm. J Korean Med Sci 20 2 (2005) 329-330
30. Coleman P.J., and Goddard J.M. Harlequin syndrome following internal jugular vein catheterization in an adult under general anesthetic. Anesthesiology 97 4 (2002) 1041
31. Burlacu C.L., and Buggy D.J. Coexisting harlequin and Horner syndromes after high thoracic paravertebral anaesthesia. Br J Anaesth 95 6 (2005) 822-824
32. Noda S. Harlequin syndrome due to superior mediastinal neurinoma. J Neurol Neurosurg Psychiatr 54 8 (1991) 744
33. Abrahamian L.M., Rothe M.J., and Grant-Kels J.M. Primary telangiectasia of childhood. Int J Dermatol 31 5 (1992) 307-313
34. Gatti R.A. Ataxia-telangiectasia. Dermatol Clin 13 1 (1995) 1-6
35. Swift M., Morrell D., Massey R.B., et al. Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 325 26 (1991) 1831-1836
36. Reed W.B., Epstein W.L., Boder E., et al. Cutaneous manifestations of ataxia-telangiectasia. JAMA 195 9 (1966) 746-753
37. Su Y., and Swift M. Mortality rates among carriers of ataxia-telangiectasia mutant alleles. Ann Intern Med 133 10 (2000) 770-778
38. Khanna K.K. Cancer risk and the ATM gene: a continuing debate. J Natl Cancer Inst 92 10 (2000) 795-802
39. Boultwood J. Ataxia telangiectasia gene mutations in leukaemia and lymphoma. J Clin Pathol 54 7 (2001) 512-516
40. German J. Bloom's syndrome. XX. The first 100 cancers. Cancer Genet Cytogenet 93 1 (1997) 100-106
41. Gretzula J.C., Hevia O., and Weber P.J. Bloom's syndrome. J Am Acad Dermatol 17 3 (1987) 479-488
42. Haneke E., and Gutschmidt E. Premature multiple Bowen's disease in poikiloderma congenitale with warty hyperkeratoses. Dermatologica 158 5 (1979) 384-388
43. Berg E., Chuang T.Y., and Cripps D. Rothmund-Thomson syndrome. A case report, phototesting, and literature review. J Am Acad Dermatol 17 2 Pt 2 (1987) 332-338
44. Van Hees C.L., Van Duinen C.M., Bruijin J.A., et al. Malignant eccrine poroma in a patient with Rothmund-Thomson syndrome. Br J Dermatol 134 4 (1996) 813-815
45. Davies M.G. Rothmund-Thomson syndrome and malignant disease. Clin Exp Dermatol 7 4 (1982) 455
46. Werder E.A., Murset G., Illig R., et al. Hypogonadism and parathyroid adenoma in congenital poikiloderma (Rothmund-Thomson syndrome). Clin Endocrinol (Oxf) 4 1 (1975) 75-82
47. Diem E. The Rothmund-Thomson-syndrome. A case report. [abstract]. Hautarzt 26 8 (1975) 425-429
48. Dick D.C., Morley W.N., and Watson J.T. Rothmund-Thomson syndrome and osteogenic sarcoma. Clin Exp Dermatol 7 1 (1982) 119-123
49. Judge M.R., Kilby A., and Harper J.I. Rothmund-Thomson syndrome and osteosarcoma. Br J Dermatol 129 6 (1993) 723-725
50. Drouin C.A., Mongrain E., Sasseville D., et al. Rothmund-Thomson syndrome with osteosarcoma. J Am Acad Dermatol 28 2 Pt 2 (1993) 301-305
51. Smith P.J., and Paterson M.C. Enhanced radiosensitivity and defective DNA repair in cultured fibroblasts derived from Rothmund Thomson syndrome patients. [abstract]. Mutat Res 94 1 (1982) 213-228
52. McLean D.I., and Haynes H.A. Cutaneous manifestations of internal malignant disease: cutaneous paraneoplastic syndromes. In: Freedberg I.M., Eisen A.Z., Wolff K., et al. (Eds). Fitzpatrick's dermatology in general medicine. 6th edition (2003), McGraw-Hill, New York 1785-1786
53. Ochshorn M., Ilie B., and Blum I. Multiple telangiectases preceding the appearance of undifferentiated bronchogenic carcinoma. Dermatologica 165 6 (1982) 620-623
54. Perniciaro C., Winkelmann R.K., Daoud M.S., et al. Malignant angioendotheliomatosis is an angiotropic intravascular lymphoma. Immunohistochemical, ultrastructural, and molecular genetics studies. Am J Dermatopathol 17 3 (1995) 242-248
55. Berger T.G., and Dawson N.A. Angioendotheliomatosis. J Am Acad Dermatol 18 2 Pt 2 (1988) 407-412
56. Requena L., and Sangueza O.P. Cutaneous vascular proliferations. Part III. Malignant neoplasms, other cutaneous neoplasms with significant vascular component, and disorders erroneously considered as vascular neoplasms. J Am Acad Dermatol 38 2 Pt 1 (1998) 143-175
57. Wilson B.B. Indurated telangiectatic plaques. Malignant angioendotheliomatosis (MAE). Arch Dermatol 128 2 (1992) 255-258
58. Diez-Porres L., Rios-Blanco J.J., Robles-Marhuenda A., et al. ANCA-associated vasculitis as paraneoplastic syndrome with colon cancer: a case report. Lupus 14 8 (2005) 632-634
59. Hayem G., Gomez M.J., Grossin M., et al. Systemic vasculitis and epithelioma. A report of three cases with a literature review. Rev Rhum Engl Ed 64 12 (1997) 816-824
60. Kurzrock R., and Cohen P.R. Vasculitis and cancer. Clin Dermatol 11 1 (1993) 175-187
61. Fernandez-Miranda C., Garcia-Marcilla A., Martin M., et al. Vasculitis associated with a myelodysplastic syndrome: a report of 5 cases. [abstract]. Med Clin (Barc) 103 14 (1994) 539-542
62. Hamidou M.A., Boumalassa A., Larroche C., et al. Systemic medium-sized vessel vasculitis associated with chronic myelomonocytic leukemia. Semin Arthritis Rheum 31 2 (2001) 119-126
63. Gonzalez-Gay M.A., Garcia-Porrua C., Salvarani C., et al. Cutaneous vasculitis and cancer: a clinical approach. Clin Exp Rheumatol 18 3 (2000) 305-307
64. Gabriel S.E., Conn D.L., Phyliky R.L., et al. Vasculitis in hairy cell leukemia: review of literature and consideration of possible pathogenic mechanisms. J Rheumatol 13 6 (1986) 1167-1172
65. Gerber M.A., Brodin A., Steinberg D., et al. Periarteritis nodosa, Australia antigen and lymphatic leukemia. N Engl J Med 286 1 (1972) 14-17
66. Hasegawa H., Ozawa T., Tada N., et al. Multiple myeloma-associated systemic vasculopathy due to crystalglobulin or polyarteritis nodosa. Arthritis Rheum 39 2 (1996) 330-334
67. Garcias V.A., and Herr H.W. Henoch-Schonlein purpura associated with cancer of prostate. Urology 19 2 (1982) 155-158
68. Posnett D.N., Marboe C.C., Knowles II D.M., et al. A membrane antigen (HC1) selectively present on hairy cell leukemia cells, endothelial cells, and epidermal basal cells. J Immunol 132 6 (1984) 2700-2702
69. Klima M., and Waddell C.C. Hairy cell leukemia associated with focal vascular damage. Hum Pathol 15 7 (1984) 657-659
70. Kurzrock R., Cohen P.R., and Markowitz A. Clinical manifestations of vasculitis in patients with solid tumors. A case report and review of the literature. Arch Intern Med 154 3 (1994) 334-340
71. Schonauer V., Kyrle P.A., Weltermann A., et al. Superficial thrombophlebitis and risk for recurrent venous thromboembolism. J Vasc Surg 37 4 (2003) 834-838
72. Tasi S.H., Juan C.J., Dai M.S., et al. Trousseau's syndrome related to adenocarcinoma of the colon and cholangiocarcinoma. Eur J Neurol 11 7 (2004) 493-496
73. Batsis J.A., and Morgenthaler T.I. Trousseau syndrome and the unknown cancer: use of positron emission tomographic imaging in a patient with a paraneoplastic syndrome. Mayo Clin Proc 80 4 (2005) 537-540
74. Lesher Jr. J.L. Thrombophlebitis and thromboembolic problems in malignancy. Clin Dermatol 11 1 (1993) 159-163
75. Pinzon R., Drewinko B., Trujillo J.M., et al. Pancreatic carcinoma and Trousseau's syndrome: experience at a large cancer center. J Clin Oncol 4 4 (1986) 509-514
76. Mayor M., Buron I., de Mora J.C., et al. Mondor's disease. Int J Dermatol 39 12 (2000) 922-925
77. Oldfield M.C. Mondor's disease. A superficial phlebitis of the breast. Lancet 1 (1962) 994-996
78. Catania S., Zurrida S., Veronesi P., et al. Mondor's disease and breast cancer. Cancer 69 9 (1992) 2267-2270
79. Bartolo M., Spigone C., and Antignani P.L. Contribution to the recognition of Mondor's phlebitis. [abstract]. J Mal Vasc 8 3 (1983) 253-256
80. Skipworth G.B., Morris J.B., and Goldstein N. Bilateral Mondor's disease. Arch Dermatol 95 1 (1967) 95-97
81. Samlaska C.P., and James W.D. Superficial thrombophlebitis. II. Secondary hypercoagulable states. J Am Acad Dermatol 23 1 (1990) 1-18
82. Baron J.A., Gridley G., Weiderpass E., et al. Venous thromboembolism and cancer. Lancet 351 9109 (1998) 1077-1080 [Erratum in Lancet 2000;355(9205):758]
83. Lee A.Y., and Levine M.N. Venous thromboembolism and cancer: risks and outcomes. Circulation 107 23 Suppl 1 (2003) I17-I21
84. Prandoni P., Lensing A.W., Buller H.R., et al. Deep-vein thrombosis and the incidence of subsequent symptomatic cancer. N Engl J Med 327 16 (1992) 1128-1133
85. Ambrus J.L., Ambrus C.M., Mink I.B., et al. Causes of death in cancer patients. J Med 6 1 (1975) 61-64
86. Aderka D., Brown A., Zelikovski A., et al. Idiopathic deep vein thrombosis in an apparently healthy patient as a premonitory sign of occult cancer. Cancer 57 9 (1986) 1846-1849
87. Naschitz J.E., Yeshurun D., and Abrahamson J. Thromboembolism. Clues for the presence of occult neoplasia. Int Angiol 8 4 (1989) 200-205
88. Monreal M., Lafoz E., Casals A., et al. Occult cancer in patients with deep venous thrombosis. A systematic approach. Cancer 67 2 (1991) 541-545
89. Girolami A., Prandoni P., Zanon E., et al. Venous thromboses of upper limbs are more frequently associated with occult cancer as compared with those of lower limbs. Blood Coagul Fibrinolysis 10 8 (1999 Dec) 455-457
90. Naschitz J.E., Yeshurun D., Eldar S., et al. Diagnosis of cancer-associated vascular disorders. Cancer 77 9 (1996) 1759-1767
91. Donati M.B. Cancer and thrombosis: from phlegmasia alba dolens to transgenic mice. Thromb Haemost 74 1 (1995) 278-281
92. Walsh-McMonagle D., and Green D. Low-molecular-weight heparin in the management of Trousseau's syndrome. Cancer 80 4 (1997) 649-655
93. Glassman A.B., and Jones E. Thrombosis and coagulation abnormalities associated with cancer. Ann Clin Lab Sci 24 1 (1994) 1-5
94. Lee A.Y. Cancer and thromboembolic disease: pathogenic mechanisms. Cancer Treat Rev 28 3 (2002) 137-140
95. Sack Jr. G.H., Levin J., and Bell W.R. Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore) 56 1 (1977) 1-37
96. Sun N.C., McAfee W.M., Hum G.J., et al. Hemostatic abnormalities in malignancy, a prospective study of one hundred eight patients. Part I. Coagulation studies. Am J Clin Pathol 71 1 (1979) 10-16
97. Gasic G.J., Gasic T.B., Galanti N., et al. Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease. Int J Cancer 11 3 (1973) 704-718
98. Fink K., and Al-Mondhiry H. Idiopathic thrombocytopenic purpura in lymphoma. Cancer 37 4 (1976) 1999-2004
99. Glaspy J.A. Disturbances in hemostasis in patients with B-cell malignancies. Semin Thromb Hemost 18 4 (1992) 440-448
100. de Latour R.P., Des Guetz G., Laurence V., et al. Breast cancer associated with idiopathic thrombocytopenic purpura: a single center series of 10 cases. Am J Clin Oncol 27 4 (2004) 333-336
101. Jakway J.L. Acquired von Willebrand's disease in malignancy. Semin Thromb Hemost 18 4 (1992) 434-439
102. Kaden B.R., Rosse W.F., and Hauch T.W. Immune thrombocytopenia in lymphoproliferative diseases. Blood 53 4 (1979) 545-551
103. Porrata L.F., Alberts S., Hook C., et al. Idiopathic thrombocytopenic purpura associated with breast cancer: a case report and review of the current literature. Am J Clin Oncol 22 4 (1999) 411-413
104. Loreto M.F., De Martinis M., Corsi M.P., et al. Coagulation and cancer: implications for diagnosis and management. Pathol Oncol Res 6 4 (2000) 301-312
105. Stahl R.L., Chan W., Duncan A., et al. Malignant angioendotheliomatosis presenting as disseminated intravascular coagulopathy. Cancer 68 10 (1991) 2319-2323
106. Sallah S., Wan J.Y., Nguyen N.P., et al. Disseminated intravascular coagulation in solid tumors: clinical and pathologic study. Thromb Haemost 86 3 (2001) 828-833
107. Antman K.H., Skarin A.T., Mayer R.J., et al. Microangiopathic hemolytic anemia and cancer: a review. Medicine (Baltimore) 58 5 (1979) 377-384
108. von Bubnoff N., Sandherr M., Schneller F., et al. Thrombotic thrombocytopenic purpura in metastatic carcinoma of the breast. Am J Clin Oncol 23 1 (2000) 74-77
109. Kwaan H.C., and Soff G.A. Management of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Semin Hematol 34 2 (1997) 159-166
110. DeCross A.J., and Sahasrabudhe D.M. Paraneoplastic Raynaud's phenomenon. Am J Med 92 5 (1992) 571-572
111. Kurzrock R., and Cohen P.R. Erythromelalgia and myeloproliferative disorders. Arch Intern Med 149 1 (1989) 105-109
112. McKee Jr. L.C., and Collins R.D. Intravascular leukocyte thrombi and aggregates as a cause of morbidity and mortality in leukemia. Medicine (Baltimore) 53 6 (1974) 463-478
113. Hawley P.R., Johnston A.W., and Rankin J.T. Association between digital ischaemia and malignant disease. Br Med J 3 559 (1967) 208-212