Cytoplasmic Binding Partners of the Platelet Integrin α iIbβ 3

Frontiers in Bioscience

Volumn 12, Issue 6, 2007, Pages 2038-2049

  Bonner, Melissa A ^a   Naik, Ulhas P ^a,b  

^a UNIVERSITY OF DELAWARE   (United States)

^b University of Delaware   (United States)

Author keywords

CIB1; Inside out signaling; Outside in signaling; Review

Indexed keywords

CALCIUM BINDING PROTEIN; CIB1 PROTEIN, HUMAN; FIBRINOGEN RECEPTOR;

CHEMISTRY; CYTOPLASM; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTE;

BLOOD PLATELETS; CALCIUM-BINDING PROTEINS; CYTOPLASM; HUMANS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; SIGNAL TRANSDUCTION;

EID: 36048980473     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/2209     Document Type: Article

References (93)

1. Coller, B. S.: A Brief and Highly Selective History of Ideas about Platelets in Health and Disease. In: Platelets. Ed: A. D. Michelson. Elsevier Science, San Diego (2002)
2. Nurden, A. T.: Glanzmann thrombasthenia. Orphanet J Rare Dis, 1, 10 (2006)
3. Aster, R. H.: Immune thrombocytopenia caused by glycoprotein IIb/IIIa inhibitors. Chest, 127, 53S-59S (2005) (Pubitemid 40224082)
4. Mannel, D. N. & G. E. Grau: Role of platelet adhesion in homeostasis and immunopathology. Mol Pathol, 50, 175-85 (1997) (Pubitemid 27454986)
5. Coller, B. S.: Blockade of platelet GPIIb/IIIa receptors as an antithrombotic strategy. Circulation, 92, 2373-80 (1995)
6. Topol, E. J., T. V. Byzova & E. F. Plow: Platelet GPIIb-IIIa blockers. Lancet, 353, 227-31 (1999) (Pubitemid 29088046)
7. Xiao, T., J. Takagi, B. S. Coller, J. H. Wang & T. A. Springer: Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature, 432, 59-67 (2004) (Pubitemid 39490825)
8. Shattil, S. J. & M. H. Ginsberg: Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology. J Clin Invest, 100, 1-5 (1997)
9. Shattil, S. J.: Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways. Thromb Haemost, 82, 318-25 (1999)
10. Calvete, J. J.: On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor. Proc Soc Exp Biol Med, 208, 346-60 (1995)
11. Clemetson, K. J.: Platelet Receptors. In: Platelets. Ed: A. D. Michelson. Elsevier Science, San Diego (2002)
12. Salas, A., M. Shimaoka, U. Phan, M. Kim & T. A. Springer: Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state. J Biol Chem, 281, 10876-82 (2006) (Pubitemid 43855510)
13. Ostermann, G., L. Fraemohs, T. Baltus, A. Schober, M. Lietz, A. Zernecke, E. A. Liehn & C. Weber: Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A. Arterioscler Thromb Vasc Biol, 25, 729-35 (2005) (Pubitemid 40463861)
14. Hato, T., Ginsberg, M. H., and Shattil, S. J.: Integrin alphaIIbbeta3. In: Platelets. Ed: A. D. Michelson. Elsevier Science, San Diego (2002)
15. Bennett, J. S.: Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest, 115, 3363-9 (2005) (Pubitemid 43121820)
16. Clemetson, K. J.: Platelet activation: signal transduction via membrane receptors. Thromb Haemost, 74, 111-6 (1995)
17. Hawiger, J.: Mechanisms involved in platelet vessel wall interaction. Thromb Haemost, 74, 369-72 (1995)
18. Kouns, W. C., C. F. Fox, W. J. Lamoreaux, L. B. Coons & L. K. Jennings: The effect of glycoprotein IIb-IIIa receptor occupancy on the cytoskeleton of resting and activated platelets. J Biol Chem, 266, 13891-900 (1991) (Pubitemid 21907436)
19. Law, D. A., L. Nannizzi-Alaimo & D. R. Phillips: Outside-in integrin signal transduction. Alpha IIb beta 3-GP IIb IIIa)tyrosine phosphorylation induced by platelet aggregation. J Biol Chem, 271, 10811-5 (1996)
20. Parise, L. V.: Integrin alpha (IIb)beta (3)signaling in platelet adhesion and aggregation. Curr Opin Cell Biol, 11, 597-601 (1999) (Pubitemid 29460401)
21. Payrastre, B., K. Missy, C. Trumel, S. Bodin, M. Plantavid & H. Chap: The integrin alpha IIb/beta 3 in human platelet signal transduction. Biochem Pharmacol, 60, 1069-74 (2000)
22. Stouffer, G. A. & S. S. Smyth: Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells. Arterioscler Thromb Vasc Biol, 23, 1971-8 (2003) (Pubitemid 37433188)
23. Shattil, S. J., H. Kashiwagi & N. Pampori: Integrin signaling: the platelet paradigm. Blood, 91, 2645-57 (1998) (Pubitemid 28227512)
24. Hughes, P. E., F. Diaz-Gonzalez, L. Leong, C. Wu, J. A. McDonald, S. J. Shattil & M. H. Ginsberg: Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem, 271, 6571-4 (1996)
25. Hwang, P. M. & H. J. Vogel: Structures of the platelet calcium-and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies. J Mol Recognit, 13, 83-92 (2000) (Pubitemid 30257942)
26. O'Toole, T. E., D. Mandelman, J. Forsyth, S. J. Shattil, E. F. Plow & M. H. Ginsberg: Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa)by the cytoplasmic domain of alpha IIb. Science, 254, 845-7 (1991) (Pubitemid 21917409)
27. Tadokoro, S., S. J. Shattil, K. Eto, V. Tai, R. C. Liddington, J. M. de Pereda, M. H. Ginsberg & D. A. Calderwood: Talin binding to integrin beta tails: a final common step in integrin activation. Science, 302, 103-6 (2003) (Pubitemid 37210697)
28. Ginsberg, M. H., A. Partridge & S. J. Shattil: Integrin regulation. Curr Opin Cell Biol, 17, 509-16 (2005) (Pubitemid 41267165)
29. Kloczewiak, M., S. Timmons, M. A. Bednarek, M. Sakon & J. Hawiger: Platelet receptor recognition domain on the gamma chain of human fibrinogen and its synthetic peptide analogues. Biochemistry, 28, 2915-9 (1989) (Pubitemid 19099470)
30. Kloczewiak, M., S. Timmons, T. J. Lukas & J. Hawiger: Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the gamma chain. Biochemistry, 23, 1767-74 (1984) (Pubitemid 14139817)
31. Kato, A., N. Kawamata, K. Tamayose, M. Egashira, R. Miura, T. Fujimura, K. Murayama & K. Oshimi: Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3. J Biol Chem, 277, 28934-41 (2002)
32. Knezevic, I., T. M. Leisner & S. C. Lam: Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa)to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3. J Biol Chem, 271, 16416-21 (1996) (Pubitemid 26236268)
33. Larkin, D., D. Murphy, D. F. Reilly, M. Cahill, E. Sattler, P. Harriott, D. J. Cahill & N. Moran: ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation. J Biol Chem, 279, 27286-93 (2004) (Pubitemid 38812568)
34. Naik, U. P., P. M. Patel & L. V. Parise: Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J Biol Chem, 272, 4651-4 (1997) (Pubitemid 27090004)
35. Pfaff, M., S. Liu, D. J. Erle & M. H. Ginsberg: Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins. J Biol Chem, 273, 6104-9 (1998) (Pubitemid 28144690)
36. Rojiani, M. V., B. B. Finlay, V. Gray & S. Dedhar: In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin)with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. Biochemistry, 30, 9859-66 (1991)
37. Vijayan, K. V., Y. Liu, T. T. Li & P. F. Bray: Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling. J Biol Chem, 279, 33039-42 (2004) (Pubitemid 39062944)
38. Buensuceso, C. S., A. Obergfell, A. Soriani, K. Eto, W. B. Kiosses, E. G. Arias-Salgado, T. Kawakami & S. J. Shattil: Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta. J Biol Chem, 280, 644-53 (2005) (Pubitemid 40165031)
39. Cowan, K. J., D. A. Law & D. R. Phillips: Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling. J Biol Chem, 275, 36423-9 (2000)
40. Lin, S. Y., S. Raval, Z. Zhang, M. Deverill, K. A. Siminovitch, D. R. Branch & B. Haimovich: The proteintyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin. J Biol Chem, 279, 25755-64 (2004) (Pubitemid 38756839)
41. Obergfell, A., K. Eto, A. Mocsai, C. Buensuceso, S. L. Moores, J. S. Brugge, C. A. Lowell & S. J. Shattil: Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol, 157, 265-75 (2002) (Pubitemid 34839823)
42. Otey, C. A., G. B. Vasquez, K. Burridge & B. W. Erickson: Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain. J Biol Chem, 268, 21193-7 (1993) (Pubitemid 23292306)
43. Pasquet, J. M., M. Noury & A. T. Nurden: Evidence that the platelet integrin alphaIIb beta3 is regulated by the integrin-linked kinase, ILK, in a PI3-kinase dependent pathway. Thromb Haemost, 88, 115-22 (2002) (Pubitemid 34752276)
44. Reddy, K. B., P. Gascard, M. G. Price, E. V. Negrescu & J. E. Fox: Identification of an interaction between the mband protein skelemin and beta-integrin subunits. Colocalization of a skelemin-like protein with beta1-and beta3-integrins in non-muscle cells. J Biol Chem, 273, 35039-47 (1998) (Pubitemid 29028204)
45. Rodriguez, M. M., D. Ron, K. Touhara, C. H. Chen & D. Mochly-Rosen: RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro. Biochemistry, 38, 13787-94 (1999) (Pubitemid 29504208)
46. Shattil, S. J., T. O'Toole, M. Eigenthaler, V. Thon, M. Williams, B. M. Babior & M. H. Ginsberg: Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol, 131, 807-16 (1995)
47. Schaller, M. D., C. A. Otey, J. D. Hildebrand & J. T. Parsons: Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol, 130, 1181-7 (1995)
48. Woodside, D. G., A. Obergfell, L. Leng, J. L. Wilsbacher, C. K. Miranti, J. S. Brugge, S. J. Shattil & M. H. Ginsberg: Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains. Curr Biol, 11, 1799-804 (2001) (Pubitemid 33092170)
49. Puszkin, E. G., E. A. Mauss & M. B. Zucker: Assembly and GPIIIa content of cytoskeletal core in platelets agglutinated with bovine von Willebrand factor. Blood, 76, 1572-9 (1990) (Pubitemid 20364021)
50. Arias-Salgado, E. G., F. Haj, C. Dubois, B. Moran, A. Kasirer-Friede, B. C. Furie, B. Furie, B. G. Neel & S. J. Shattil: PTP-1B is an essential positive regulator of platelet integrin signaling. J Cell Biol, 170, 837-45 (2005) (Pubitemid 41242115)
51. Barry, W. T., C. Boudignon-Proudhon, D. D. Shock, A. McFadden, J. M. Weiss, J. Sondek & L. V. Parise: Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain. J Biol Chem, 277, 28877-83 (2002)
52. Tsuboi, S.: Calcium integrin-binding protein activates platelet integrin alpha IIbbeta 3. J Biol Chem, 277, 1919-23 (2002) (Pubitemid 34968768)
53. Naik, U. P. & M. U. Naik: Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen. Blood, 102, 1355-62 (2003) (Pubitemid 36988043)
54. Tsuboi, S., S. Nonoyama & H. D. Ochs: Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion. EMBO Rep, 7, 506-11 (2006) (Pubitemid 43904867)
55. Bertagnolli, M. E., S. J. Locke, M. E. Hensler, P. F. Bray & M. C. Beckerle: Talin distribution and phosphorylation in thrombin-activated platelets. J Cell Sci, 106 ( Pt 4), 1189-99 (1993) (Pubitemid 24018404)
56. Tremuth, L., S. Kreis, C. Melchior, J. Hoebeke, P. Ronde, S. Plancon, K. Takeda & N. Kieffer: A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain. J Biol Chem, 279, 22258-66 (2004) (Pubitemid 38679422)
57. Yan, B., D. A. Calderwood, B. Yaspan & M. H. Ginsberg: Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. J Biol Chem, 276, 28164-70 (2001)
58. Calderwood, D. A., S. J. Shattil & M. H. Ginsberg: Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J Biol Chem, 275, 22607-10 (2000) (Pubitemid 30646138)
59. Kralisz, U. & C. S. Cierniewski: Association of pp60csrc with alpha IIb beta 3 in resting platelets. Biochem Mol Biol Int, 45, 735-43 (1998) (Pubitemid 28393541)
60. Dorahy, D. J., M. C. Berndt & G. F. Burns: Capture by chemical crosslinkers provides evidence that integrin alpha IIb beta 3 forms a complex with protein tyrosine kinases in intact platelets. Biochem J, 309 ( Pt 2), 481-90 (1995)
61. Reilly, D., D. Larkin, M. Devocelle, D. J. Fitzgerald & N. Moran: Calreticulin-independent regulation of the platelet integrin alphaIIbbeta3 by the KVGFFKR alphaIIbcytoplasmic motif. Platelets, 15, 43-54 (2004) (Pubitemid 38292182)
62. Leung-Hagesteijn, C. Y., K. Milankov, M. Michalak, J. Wilkins & S. Dedhar: Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin alphasubunit-binding protein. J Cell Sci, 107 ( Pt 3), 589-600 (1994) (Pubitemid 24091864)
63. Ghebrehiwet, B. & E. I. Peerschke: cC1q-R (calreticulin)and gC1q-R/p33: ubiquitously expressed multi-ligand binding cellular proteins involved in inflammation and infection. Mol Immunol, 41, 173-83 (2004) (Pubitemid 38668627)
64. Goicoechea, S., M. A. Pallero, P. Eggleton, M. Michalak & J. E. Murphy-Ullrich: The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. J Biol Chem, 277, 37219-28 (2002)
65. Liu, S., D. A. Calderwood & M. H. Ginsberg: Integrin cytoplasmic domain-binding proteins. J Cell Sci, 113 ( Pt 20), 3563-71 (2000)
66. Ohmori, T., Y. Yatomi, N. Asazuma, K. Satoh & Y. Ozaki: Involvement of proline-rich tyrosine kinase 2 in platelet activation: tyrosine phosphorylation mostly dependent on alphaIIbbeta3 integrin and protein kinase C, translocation to the cytoskeleton and association with Shc through Grb2. Biochem J, 347, 561-9 (2000) (Pubitemid 30229405)
67. Eigenthaler, M., L. Hofferer, S. J. Shattil & M. H. Ginsberg: A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin. J Biol Chem, 272, 7693-8 (1997) (Pubitemid 27137320)
68. Kashiwagi, H., M. A. Schwartz, M. Eigenthaler, K. A. Davis, M. H. Ginsberg & S. J. Shattil: Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail. J Cell Biol, 137, 1433-43 (1997) (Pubitemid 27265953)
69. Ron, D., C. H. Chen, J. Caldwell, L. Jamieson, E. Orr & D. Mochly-Rosen: Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proc Natl Acad Sci U S A, 91, 839-43 (1994) (Pubitemid 24048462)
70. Arias-Salgado, E. G., S. Lizano, S. Sarkar, J. S. Brugge, M. H. Ginsberg & S. J. Shattil: Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A, 100, 13298-302 (2003) (Pubitemid 37444736)
71. Naik, M. U. & U. P. Naik: Calcium-and integrinbinding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen. Blood, 102, 3629-36 (2003) (Pubitemid 37409381)
72. Shock, D. D., U. P. Naik, J. E. Brittain, S. K. Alahari, J. Sondek & L. V. Parise: Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton. Biochem J, 342 Pt 3, 729-35 (1999) (Pubitemid 29452660)
73. Stabler, S. M., L. L. Ostrowski, S. M. Janicki & M. J. Monteiro: A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein. J Cell Biol, 145, 1277-92 (1999) (Pubitemid 29293638)
74. Blamey, C. J., C. Ceccarelli, U. P. Naik & B. J. Bahnson: The crystal structure of calcium-and integrinbinding protein 1: insights into redox regulated functions. Protein Sci, 14, 1214-21 (2005) (Pubitemid 40577801)
75. Gentry, H. R., A. U. Singer, L. Betts, C. Yang, J. D. Ferrara, J. Sondek & L. V. Parise: Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. J Biol Chem, 280, 8407-15 (2005) (Pubitemid 40349745)
76. Vallar, L., C. Melchior, S. Plancon, H. Drobecq, G. Lippens, V. Regnault & N. Kieffer: Divalent cations differentially regulate integrin alphaIIb cytoplasmic tail binding to beta3 and to calcium-and integrin-binding protein. J Biol Chem, 274, 17257-66 (1999)
77. Ames, J. B., R. Ishima, T. Tanaka, J. I. Gordon, L. Stryer & M. Ikura: Molecular mechanics of calciummyristoyl switches. Nature, 389, 198-202 (1997)
78. Meyer, T. & J. D. York: Calcium-myristoyl switches turn on new lights. Nat Cell Biol, 1, E93-5 (1999)
79. Yamniuk, A. P., H. Ishida & H. J. Vogel: The interaction between CIB1 and the alpha IIb integrin cytoplasmic domain involves a novel C-terminal displacement mechanism. J Biol Chem (2006)
80. Yuan, W., T. M. Leisner, A. W. McFadden, Z. Wang, M. K. Larson, S. Clark, C. Boudignon-Proudhon, S. C. Lam & L. V. Parise: CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation. J Cell Biol, 172, 169-75 (2006) (Pubitemid 43112965)
81. Shattil, S. J. & A. D. Leavitt: All in the family: primary megakaryocytes for studies of platelet alphaIIbbeta3 signaling. Thromb Haemost, 86, 259-65 (2001) (Pubitemid 32663956)
82. Kauselmann, G., M. Weiler, P. Wulff, S. Jessberger, U. Konietzko, J. Scafidi, U. Staubli, J. Bereiter-Hahn, K.Strebhardt & D. Kuhl: The polo-like protein kinases Fnk and Snk associate with a Ca (2+)-and integrin-binding protein and are regulated dynamically with synaptic plasticity. Embo J, 18, 5528-39 (1999) (Pubitemid 29486372)
83. Wu, X. & M. R. Lieber: Interaction between DNAdependent protein kinase and a novel protein, KIP. Mutat Res, 385, 13-20 (1997) (Pubitemid 27475666)
84. Leisner, T. M., M. Liu, Z. M. Jaffer, J. Chernoff & L. V. Parise: Essential role of CIB1 in regulating PAK1 activation and cell migration. J Cell Biol, 170, 465-76 (2005) (Pubitemid 41126945)
85. Whitehouse, C., J. Chambers, K. Howe, M. Cobourne, P. Sharpe & E. Solomon: NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1)and calcium and integrin binding protein (CIB)and shows developmentally restricted expression in the neural tube. Eur J Biochem, 269, 538-45 (2002) (Pubitemid 34128011)
86. Haataja, L., V. Kaartinen, J. Groffen & N. Heisterkamp: The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha (IIb)beta (3)-mediated adhesion and spreading. J Biol Chem, 277, 8321-8 (2002) (Pubitemid 34968292)
87. Henderson, M. J., A. J. Russell, S. Hird, M. Munoz, J. L. Clancy, G. M. Lehrbach, S. T. Calanni, D. A. Jans, R. L. Sutherland & C. K. Watts: EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J Biol Chem, 277, 26468-78 (2002) (Pubitemid 34967142)
88. Hollenbach, A. D., C. J. McPherson, I. Lagutina & G. Grosveld: The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3. Biochim Biophys Acta, 1574, 321-8 (2002) (Pubitemid 34457906)
89. Ito, A., T. Uehara & Y. Nomura: Isolation of Ich-1S (caspase-2S)-binding protein that partially inhibits caspase activity. FEBS Lett, 470, 360-4 (2000) (Pubitemid 30169293)
90. Fang, X., C. Chen, Q. Wang, J. Gu & C. Chi: The interaction of the calcium-and integrin-binding protein (CIBP)with the coagulation factor VIII. Thromb Res, 102, 177-85 (2001) (Pubitemid 32373227)
91. Lee, G. E., E. Y. Yu, C. H. Cho, J. Lee, M. T. Muller & I. K. Chung: DNA-protein kinase catalytic subunitinteracting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase. J Biol Chem, 279, 34750-5 (2004) (Pubitemid 39318106)
92. Tahara, E., Jr., H. Tahara, M. Kanno, K. Naka, Y. Takeda, T. Matsuzaki, R. Yamazaki, H. Ishihara, W. Yasui, J. C. Barrett, T. Ide & E. Tahara: G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. Cancer Immunol Immunother, 54, 729-40 (2005) (Pubitemid 40977141)
93. White, C., J. Yang, M. J. Monteiro & J. K. Foskett: CIB1, a Ubiquitously Expressed Ca2+-binding Protein Ligand of the InsP3 Receptor Ca2+ Release Channel. J Biol Chem, 281, 20825-20833 (2006) (Pubitemid 44115424)