Phosphorylation of focal adhesion kinase at Tyrosine 407 negatively regulates Ras transformation of fibroblasts

Biochemical and Biophysical Research Communications

Volumn 364, Issue 4, 2007, Pages 1062-1066

  Jeon, Jihyun ^a   Lee, Hyangjin ^a   Park, Haein ^a   Lee, Jung hyun ^a   Choi, Sojoong ^a   Hwang, Jisun ^b   Han, Inn Oc ^b   Oh, Eok Soo ^a  

^a Ewha Womans University   (South Korea)

^b Inha University School of Medicine   (South Korea)

Author keywords

Focal adhesion kinase; Signal transduction; Transformation; Tyrosine phosphorylation

Indexed keywords

FOCAL ADHESION KINASE; RAS PROTEIN; TRICHOSTATIN A;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; FIBROBLAST; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL;

ANIMALS; BINDING SITES; CACO-2 CELLS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; FIBROBLASTS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; MICE; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN BINDING; RAS PROTEINS; RATS; TYROSINE;

RATTUS;

EID: 36048974618     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.10.134     Document Type: Article

References (16)

1. Guan J.L. Focal adhesion kinase in integrin signaling. Matrix Biol. 16 (1997) 195-200
2. Hanks S.K., and Polte T.R. Signaling through focal adhesion kinase. Bioessays 19 (1997) 137-145
3. Schlaepfer D.D., and Mitra S.K. Multiple connections link FAK to cell motility and invasion. Curr. Opin. Genet. Dev. 14 (2004) 92-101
4. Lim Y., Park H., Jeon J., Han I., Kim J., Jho E.H., and Oh E.S. Focal adhesion kinase is negatively regulated by phosphorylation at tyrosine 407. J. Biol. Chem. 282 (2007) 10398-10404
5. McLean G.W., Carragher N.O., Avizienyte E., Evans J., Brunton V.G., and Frame M.C. The role of focal-adhesion kinase in cancer-a new therapeutic opportunity. Nat. Rev. Cancer 5 (2005) 505-515
6. Schlaepfer D.D., Mitra S.K., and Ilic D. Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim. Biophys. Acta 1692 (2004) 77-102
7. Hecker T.P., and Gladson C.L. Focal adhesion kinase in cancer. Front Biosci. 8 (2003) s705-s714
8. Kornberg L.J. Focal adhesion kinase and its potential involvement in tumor invasion and metastasis. Head Neck 20 (1998) 745-752
9. Lim Y., Han I., Jeon J., Park H., Bahk Y.Y., and Oh E.S. Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts. J. Biol. Chem. 279 (2004) 29060-29065
10. Benlimame N., He Q., Jie S., Xiao D., Xu Y.J., Loignon M., and Schlaepfer D.D. FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. J. Cell Biol. 171 (2005) 505-516
11. Reiske H.R., Zhao J.H., Han D.C., Cooper L.A., and Guan J.L. Analysis of FAK-associated signaling pathways in the regulation of cell cycle progression. FEBS Lett. 486 (2000) 275-280
12. Lim Y., Han I., Kwon H.J., and Oh E.S. Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in Ras-transformed fibroblasts. J. Biol. Chem. 277 (2002) 12735-12740
13. Yu H.G., Tong S.L., Ding Y.M., Ding J., Fang X.M., Fang X.F., Zhang X.F., Liu Z.J., Zhou Y.H., Liu Q.S., Luo H.S., and Yu J.P. Enhanced expression of cholecystokinin-2 receptor promotes the progression of colon cancer through activation of focal adhesion kinase. Int. J. Cancer 119 (2006) 2724-2732
14. Sawhney R.S., Cookson M.M., Omar Y., Hauser J., and Brattain M.G. Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway. J. Biol. Chem. 281 (2006) 8497-8510
15. Park H., Han I., Kwon H.J., and Oh E.S. Focal adhesion kinase regulates syndecan-2-mediated tumorigenic activity of HT1080 fibrosarcoma cells. Cancer Res. 65 (2005) 9899-9905
16. Hanada M., Tanaka K., Matsumoto Y., Nakatani F., Sakimura R., Matsunobu T., Li X., Okada T., Nakamura T., Takasaki M., and Iwamoto Y. Focal adhesion kinase is activated in invading fibrosarcoma cells and regulates metastasis. Clin. Exp. Metastasis 22 (2005) 485-494