Antiplasmodial activity of extracts of selected medicinal plants used by local communities in western Uganda for treatment of malaria

African Journal of Ecology

Volumn 45, Issue SUPPL. 3, 2007, Pages 94-98

  Katuura, Esther ^a   Waako, Paul ^a   Tabuti, John R S ^a   Bukenya Ziraba, Remigius ^a   Ogwal Okeng, Jasper ^b  

^a MAKERERE UNIVERSITY MEDICAL SCHOOL   (Uganda)

^b GULU UNIVERSITY   (Uganda)

Author keywords

Antimalarial; Plasmodium falciparum; Traditional medicine; Uganda

Indexed keywords

ANTIMALARIAL AGENT; CHLOROFORM; DISEASE TREATMENT; ENZYME ACTIVITY; MEDICINAL PLANT; PLANT EXTRACT; PROTOZOAN; TRADITIONAL MEDICINE;

AFRICA; EAST AFRICA; SOUTHERN PROVINCE [UGANDA]; SUB-SAHARAN AFRICA; UGANDA; WESTERN PROVINCE [UGANDA];

CONYZA; CONYZA SP.; ERYTHROPHLEUM; HEDERA; INDIGOFERA; LANTANA; LANTANA TRIFOLIA; MAESA LANCEOLATA; PLASMODIUM FALCIPARUM; RHUS NATALENSIS; TODDALIA ASIATICA; VERNONIA; VERNONIA LASIOPUS;

EID: 36048948234     PISSN: 01416707     EISSN: 13652028     Source Type: Journal    
DOI: 10.1111/j.1365-2028.2007.00864.x     Document Type: Conference Paper

References (18)

1. Adjanohoun, J.E., Ahyi, M.R.A., Ake Assi, L., Alia, A.M., Amai, C.A., Gbile, Z.O., Johnson, C.L.A., Kakooko, Z.O., Lutakome, H.K., Morakinyo, O., Mubiru, N.K., Ogwal-Okeng, J.W. Soforowa, E.A. (1993) Traditional Medicine and Pharmacopoeia: Contribution to Ethnobotanical and Floristic Studies in Uganda. Scientific, Technical and Research Commission of the Organization of the African Unity (OAU/STRC), Lagos, Nigeria.
2. Bloland, P.B. Ettling, M. (1999) Making Malaria treatment policy in the face of drug resistance. Ann. Trop. Med. Parasitol. 93, 5 23.
3. Brandao, M.G., Krettli, A.U., Soares, L.S., Nery, C.G. Marinuzzi, H.C. (1997) Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds. J. Ethnopharmacol. 57, 131 138.
4. Bukenya-Ziraba, R., Doenges, P., Duez, P., Lejoly, J. Ogwal-Okeng, J 1997) Medicinal Plants Sub Sector Review: Pharmacopoeia Promoting Programme Study. Final report to Ministry of Health. Archive, Ministry of Health Uganda, Uganda.
5. Katuura, E., Waako, P., Ogwal-Okeng, J. Bukenya-Ziraba, R. (2007) Traditional treatment of Malaria in Mbarara District, South Western Uganda. Afr. J. Ecol. 45, 48 51.
6. Kilama, W.L. (2005) Ethical perspective on malaria research for Africa. Acta Trop. 95, 276 284.
7. Makler, M.T., Ries, J.M., Williams, J.A., Bancroft, J.E., Piper, R.C., Gibbins, B.L. Hinrichs, D.J. (1993) Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. Am. J. Trop. Hyg. 48, 739 741.
8. Marsh, K. (1998) Malaria disaster in Africa. Lancet 352, 924 925.
9. Mubiru, M.N., Alia, A.M., Amai, C.A., Kakooko, A.B., Mutyaba, J.B., Ogwal, J.O., Apio, S.O., Ndugga, S.B., Magimbi, J.W., Busingye, C. Basalidde, G 1994) Ethnobotanical and Traditional Healers Survey. Ethnomedicine in Uganda series, Part 1-25, Kampala.
10. Ogwal-Okeng, J 1998) Studies on the antimalarial activities of Ugandan medicinal plants. PhD thesis. Makerere University, Kampala, Uganda.
11. Sebisubi, F 2007) Extraction and characterization of possible antiplasmodial compounds from selected medicinal plant species in Uganda. PhD thesis. Makerere University, Uganda.
12. Tabuti, J.R.S., Dhillion, S.S. Lye, K.A. (2003) Traditional medicine in Bulamogi County, Uganda: its practitioners, users and viability. J. Ethnopharmacol. 8, 119 129.
13. Trager, W. Jensen, J.B. (1976) Human malaria parasites in continuous culture. Science 193, 673 675.
14. Valentin, A., Benoit-Vical, F., Moulis, C., Stanislas, E., Mallie, M., Fouraste, I. Bastide, J.M. (1997) In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides. Antimicrob. Agents Chemother. 41, 2305 2307.
15. Waako, P.J., Gumede, B., Smith, P. Folb, P.I. (2005a) The in vitro and in vivo antimalarial activity of Cardiospermum halicacabum L and Mormordica foetida Schumch Et Thonn. J. Ethnopharmacol. 99, 137 143.
16. Waako, P.J., Smith, P. Folb, P.I. (2005b) In vitro interactions of Aspilia africana Pers.) C.D.Adams, a traditional medicinal plant, with artemisinin against Plasmodium falciparum. J. Ethnopharmacol. 102, 262 268.
17. Waako, P.J., Katuura, E., Smith, P. Folb, P. (2007) East African medicinal plants as a source of lead compounds for development of new antimalarial drugs. Afr. J. Ecol. 45, 1 5.
18. Willcox, M.L. (1999) A clinical trial of 'AM', a Ugandan herbal remedy for malaria. J. Public Health Med. 21, 318 324.