High levels of cadmium and lead in seminal fluid and blood of smoking men are associated with high oxidative stress and damage in infertile subjects

Biological Trace Element Research

Volumn 120, Issue 1-3, 2007, Pages 82-91

  Kiziler, Ali Riza ^a,c   Aydemir, Birsen ^a   Onaran, Ilhan ^a   Alici, Bulent ^a   Ozkara, Hamdi ^a   Gulyasar, Tevfik ^b   Akyolcu, Mehmet Can ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b TRAKYA UNIVERSITY   (Turkey)

^c NONE   (Turkey)

Author keywords

Cadmium; Cigarette smoking; GSH; GST; Lead; Male infertility; MDA; Protein carbonyls; ROS; Semen analysis

Indexed keywords

CADMIUM; CARBONYL DERIVATIVE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LEAD; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; TOBACCO SMOKE;

ADULT; ARTICLE; BLOOD CHEMISTRY; CELL STRUCTURE; CHEMOLUMINESCENCE; CONTROLLED STUDY; CORRELATION COEFFICIENT; HUMAN; HUMAN CELL; LEAD BLOOD LEVEL; MALE; MALE INFERTILITY; OXIDATIVE STRESS; SEMINAL PLASMA; SMOKING; SPERMATOZOON; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY;

ADULT; CADMIUM; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; INFERTILITY, MALE; LEAD; MALE; OXIDATIVE STRESS; SEMEN; SMOKING;

NICOTIANA TABACUM;

EID: 36048947277     PISSN: 01634984     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12011-007-8020-8     Document Type: Article

References (43)

1. Gopalkrishnan K (1998) Characteristics of semen parameters in a selected population of Indian men over a period of ten years. Curr Sci 75:939-942
2. Stohs SJ, Baggihi D (1995) Oxidative mechanisms in the toxicity of metal ions. Free Radic Med 18:321-336
3. Pruski AM, Dixon DR (2002) Effects of cadmium on nuclear integrity and DNA repair efficiency in the gill cells of Mytilus edulis L. Aquat Toxicol 57:127-137
4. Liu J, Shen HM, Ong CN (2001) Role of intracellular thio depletion, mitochondrial dysfuction and reactive oxygen species in Salvia miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells. Life Sci 69:1833-1850
5. Halliwell B, Gutteridge JMC (1999) Free radicals in biology and medicine. Oxford University Press, Oxford, pp 584-591
6. Frei B, Forte TM, Ames BN, Cross CE (1991) Gaz phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effect of ascorbic acid. Biochem J 277:133-138
7. Chiba M, Masironi R (1992) Toxic and trace elements in tobacco and tobacco smoke. Bull World Health Organ 70:269-275
8. Saldivar L, Luna M, Reyes E, Soto R, Fortoul TI (1991) Cadmium determination in Mexican-produced tobacco. Environ Res 55:91-96
9. Elinder CG, Kjellstrom T, Hogstedt C (1985) Cancer mortality of cadmium workers. Br J Ind Med 42:651-655
10. Elliott P, Arnold R, Cockings S, Eaton N, Jarup L, Jones J, Quinn M, Rosato M, Thornton I, Toledano M, Tristan E, Wakefield J (2000) Risk of mortality, cancer incidence, and stroke in a population potentially exposed to cadmium. Occup Environ Med 57:94-97
11. Muntner P, He J, Vupputuri S, Coresh J, Batuman V (2003) Blood lead and chronic kidney disease in the general United States population: results from NHANES III. Kidney Int 63:1044-1050
12. Nash D, Magder L, Lustberg M, Sherwin RW, Rubin RJ, Kaufmann RB, Silbergerd EK (2003) Blood lead, blood pressure, and hypertension in perimenopausal and postmenopausal women. JAMA 289:1523-1532
13. Navas-Acien A, Selvin E, Sharrett AR, Calderon-Aranda E, Silbergeld E, Guallar E (2004) Lead cadmium, smoking, and increased risk of peripheral arterial disease. Circulation 109:3196-3201
14. Schrag SD, Dixon RI (1995) Occupational exposures associated with male reproductive dysfunction. Annu Rev Pharmacol Toxicol 25:567-592
15. Bench G, Corzett MH, Martinelli R, Balhorn R (1999) Cadmium concentrations in the testis, sperm, and spermatids of mice subjected to long-term cadmium chloride exposure. Cytometry 35:30-36
16. Gennart JP, Buchet JP, Roels H, Ghyselen P, Ceulemans E, Lauwerys R (1992) Fertility of male workers exposed to cadmium, lead, or manganese. Am J Epidemiol 135:1208-1219
17. Xu C, Johnson JE, Singh PK, Jones MM, Yan H, Carter CE (1996) In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent. Toxicology 107:1-8
18. Hew KW, Ericson WA, Welsh MJ (1993) A single low cadmium dose causes failure of spermiation in the rat. Toxicol Appl Pharmacol 121:15-21
19. Yang JM, Arnush M, Chen QY, Wu XD, Pang B, Jiang XZ (2003) Cadmium-induced damage to primary cultures of rat Leydig cells. Reprod Toxicol 142:553-560
20. Saarenen M, Kantola M, Saarikoski S, Vanha-Pettula T (1989) Human seminal plasma cadmium: comparison with fertility and smoking habits. Andrologia 21:140-145
21. Plechaty MM, Nolland B, Sunderman FW (1977) Lead concentrations in semen of healthy men without occupational exposure to lead. Ann Clin Lab Sci 7:515-518
22. Xu B, Chia ES, Tsakok FM, Ong CN (1993) Trace elements in blood and seminal plasma and their relationship to sperm quality. Reprod Toxicol 7:613-618
23. World Health Organization (WHO) (1999) Laboratory manual for the examination of human semen and semen-cervical mucus interaction, 4th edn. Cambridge University Press, New York
24. Brys M, Nawrocka AD, Miekos E, Zyudek C, Fonksizki M, Barecki A, Krajewska WM (1997) Zinc and cadmium analyses in human prostate neoplasm. Biol Trace Elem Res 59:145-152
25. Aydemir B, Kiziler AR, Onaran I, Alici B, Ozkara H, Akyolcu MC (2006) Impact of Cu and Fe concentrations on oxidative damage in male infertility. Biol Trace Elem Res 112:193-203
26. Saleh RA, Agarwal A (2002) Oxidative stress and male infertility: from research bench to clinical practice. J Androl 23:737-751
27. Aitken RJ, Irvine DS, Wu FC (1991) Prospective analysis of sperm-oocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility. Am J Obstet Gynecol 164:542-551
28. Buege JA, Aust STD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302-310
29. Anderson ME (1985) Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 113:548-555
30. Habig WH, Pabst MJ, Jakoby WB (1974) The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139
31. Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S, Stadtman ER (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186:464-473
32. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin Phenol Reagent. J Biol Chem 193:269-275
33. Agency for Toxic Substances and Disease Registry (1993) U.S. and public health services, Toxicological profile of lead. US Department of Health and Human Services, Public Health Services, Atlanta, GA
34. Agency for Toxic Substances and Disease Registry (1993) U.S. and public health service, Toxicological profile of cadmium. US Department of Health and Human Services, Public Health Services, Atlanta, GA
35. Chia SE, Ong CN, Lee ST, Tsakok FM (1992) Blood concentration of lead, cadmium, mercury, zinc and copper and human semen parameters. Arch Androl 29:177-183
36. Alabi NS, Whanger PD, Wu AS (1985) Interactive effect of organic and inorganic selenium with cadmium and mercury on spermatozoa oxygen consumption and motility in vitro. Biol Reprod 33:911-919
37. Murthy RC, Gupta SK, Saxena DK (1995) Nuclear alterations during acrosomal cap formation in spermatids of lead treated rats. Reprod Toxicol 9:483-489
38. Keck C, Bramkamp G, Behre HM, Muller C, Jockenhovel F, Nieschlag E (1995) Lack of correlation between cadmium in seminal plasma and fertility status of nonexposed individuals and two cadmium-exposed patients. Reprod Toxicol 9:35-40
39. Xu DX, Shen HM, Zhu QX, Chua L, Wang QN, Chia SE, Ong CN (2003) The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma. Mutat Res 534:155-163
40. Alkan I, Simsek F, Haklar G, Kervancioglu E, Ozveri H, Yalcin S, Akdas A (1997) Reactive oxygen species production by the spermatozoa of patients with idiopathic infertility: relationship to seminal plasma antioxidants. J Urol 157:140-143
41. Fraga CG, Motchnik PA, Wyrobek AJ, Rempel DM, Ames BN (1996) Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutat Res 351:199-203
42. Garg N, Singh R, Dixit J, Jain A, Tewari V (2006) Levels of lipid peroxides and antioxidants in smokers and nonsmokers. J Periodont Res 41:405-410
43. Mukhtar H, Lee PI, Bend R (1978) Glutathione S-transferase activities in rat and Mouse sperm and human semen. Biochem Biophys Res Commun 83:1093-1098