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Volumn 36, Issue 10, 2007, Pages 1270-1271

Hypervalent iodine-mediated efficient synthesis of imidazoles

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EID: 36048947028     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2007.1270     Document Type: Article
Times cited : (13)

References (15)
  • 8
    • 36049007049 scopus 로고    scopus 로고
    • Chem. Abstr. 1989, 111, 19494.
    • Chem. Abstr. 1989, 111, 19494.
  • 10
    • 36048970280 scopus 로고    scopus 로고
    • Chem. Abstr. 1988, 108, 37838.
    • Chem. Abstr. 1988, 108, 37838.
  • 15
    • 36048936861 scopus 로고    scopus 로고
    • General procedure for the synthesis of imidazole: A mixture of an aldehyde (0.5 mmol, benzoin (0.5 mmol, NH4OAc (1.5 mmol, and DIB (0.5 mmol) in ethanol (5 mL) was refluxed for 30-60 min. The reaction was monitored by TLC. After completion, the mixture was cooled and the solvent was removed under reduced pressure. Saturated aq, NaHCO3 (10 mL) was added and the mixture was extracted with EtOAc (3 × 10 mL, The extract was dried and concentrated. The residue was subjected to column chromatography (silica gel, hexane-EtOAc) to obtain pure imidazole derivative. The spectral (1H NMR and MS) data of some representative imidazoles are given below. Compound 2: 1H NMR (200 MHz, CDCl3, δ 12.16 (1H, brs, 8.06 (2H, d, J, 8.0Hz, 7.60-7.42 (4H, m, 7.40-7.06 (8H, m, FAB-MS: m/z 355, 353 [M, Na, Compound 4: 1H NMR (200 MHz, CDCl3, δ 12.68 (1H, brs, 8.39-8.21 4H, m, 7
    • +.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.