Protective effects of acetylpuerarin on focal brain ischemia-reperfusion injury in rats

Chinese Pharmaceutical Journal

Volumn 42, Issue 19, 2007, Pages 1469-1472

  Hou, Li ^a   Wei, Xin Bing ^a   Li, Xue Mei ^b   Zhong, Ying ^b   Zuo, Chun Xü ^a   Zhang, Xiu Mei ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Acetylpuerarin (compound N 2211); Antioxidation; Cerebral ischemia reperfusion injury; Free radical; Ischemic cerebral vascular disease

Indexed keywords

ACETYLPUERARIN; MALONALDEHYDE; PUERARIN; SUPEROXIDE DISMUTASE; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BASAL GANGLION; BRAIN ARTERY; BRAIN CORTEX; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; NEUROLOGIC DISEASE; NONHUMAN; RAT; REPERFUSION INJURY;

EID: 35948991420     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. CHEN L B, CHAI Q, ZHAO A P, et al. Effect of puerarin on cerebral blood flow in dog[J]. China J Chin Mater Med,1995,20(9):560-562.
2. WANG H Y, PENG Y L. Advances in study of puerarin[J]. J Shandong Pharm Ind,2001,20(4):36-37.
3. ZHU Q L, HE A X, LU X R. Effects of puerarin on the scavenge of oxygen free radicals and the antagonism against oxidative injury [J]. Pharm J Chin PLA,2001,17(1):1-3.
4. YANG W C, WAN W C, WAN P, et al. Study and prospect of puerarin[J]. Forest Sci Technol,1996(1):16-17.
5. LI X M, ZHANG X M, WEI X B, et al. Protective effect of acetylpuerarin on NO level and NOS activ1tity in brain tissue and serum of focal cerebral ischemia reperfusion injury rats[J]. Chin Pharm J,2005,40(11):829-832.
6. LIX M, WEI X B, ZHANG X M, et al. Effect of acetylpuerarin on levels of nitric oxide and endothelin in focal brain ischemia reperfusion injury rats[J]. J Shandang Univ(Health Sci),2005,43(12):1173-1177.
7. ENRIQUE Z L, PHILIP P W, SARA C, et al. Reversible middle cerebral artery occlusion without craniectomy in rats[J]. Stroke, 1989,20:84-91.
8. WANG J, ZHANG J T. Cerebral ischemia, oxygen-derived free radicals scavenger and cerebval protection[J]. Chin Pharmacol Bull,1998,14(1):8- 10.
9. CHEN M L, HU F L, YING H Z, et al. Effects of worker bee larvae and pupae on activities of SOD and contents of MDA in rats [J]. J Zhejiang Coll Tradit Chin Med, 1997,21(3):30-31.
10. SU J Y. Pathophysiology [M]. 2nd ed. Beijing: Peking Union Medical College-Beijing Medical University Joint Press,1997:135.
11. YU Z L, ZHANG G Q, ZHAO H Q. Protection of puerarin isoflavone against cerebral ischemia[J]. J Chin Pharm Univ,1997,28(1):310-312.