Tick acquisition of Ehrlichia canis from dogs treated with doxycycline hyclate

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 9, 2007, Pages 3394-3396

  Schaefer, John J ^a   Needham, Glen R ^a   Bremer, William G ^a   Rikihisa, Yasuko ^a   Ewing, S A ^b   Stich, R W ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b OKLAHOMA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE HYCLATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIUM DETECTION; CONTROLLED STUDY; DOG; DRUG EFFICACY; EHRLICHIA CANIS; EHRLICHIOSIS; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TICK; TREATMENT OUTCOME;

ANIMALS; ANTI-BACTERIAL AGENTS; ARACHNID VECTORS; DOG DISEASES; DOGS; DOXYCYCLINE; EHRLICHIA CANIS; EHRLICHIOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHIPICEPHALUS SANGUINEUS;

EID: 35948978053     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00358-07     Document Type: Article

References (23)

1. Baneth, G., T. Waner, A. Koplah, S. Weinstein, and A. Keysary. 1996. Survey of Ehrlichia canis antibodies among dogs in Israel. Vet. Rec. 138:257-259.
2. Bartsch, R. C., and R. T. Greene. 1996. Post-therapy antibody titers in dogs with ehrlichiosis: follow-up study on 68 patients treated primarily with tetracycline and/or doxycycline. J. Vet. Intern. Med. 10:271-274.
3. Botros, B. A., M. S. Elmolla, A. W. Salib, C. A. Calamaio, G. A. Dasch, and R. R. Arthur. 1995. Canine ehrlichiosis in Egypt: sero-epidemiological survey. Onderstepoort J. Vet. Res. 62:41-43.
4. Breitschwerdt, E. B., B. C. Hegarty, and S. I. Hancock. 1998. Doxycycline hyclate treatment of experimental canine ehrlichiosis followed by challenge inoculation with two Ehrlichia canis strains. Antimicrob. Agents Chemother. 42:362-368.
5. Bremer, W. G., J. J. Schaefer, E. R. Wagner, S. A. Ewing, Y. Rikihisa, G. R. Needham, S. Jittapalapong, D. L. Moore, and R. W. Stich. 2005. Transstadial and intrastadial experimental transmission of Ehrlichia canis by male Rhipicephalus sanguineus. Vet. Parasitol. 131:95-105.
6. Codner, E. C., and L. L. Farris-Smith. 1986. Characterization of the sub-clinical phase of ehrlichiosis in dogs. J. Am. Vet. Med. Assoc. 189:47-50.
7. Davidson, D. E., Jr., G. S. Dill, Jr., M. Tingpalapong, S. Premabutra, P. L. Nguen, E. H. Stephenson, and M. Ristic. 1978. Prophylactic and therapeutic use of tetracycline during an epizootic of ehrlichiosis among military dogs. J. Am. Vet. Med. Assoc. 172:697-700.
8. Dumler, J. S., A. F. Barbet, C. P. Bekker, G. A. Dasch, G. H. Palmer, S. C. Ray, Y. Rikihisa, and F. R. Rurangirwa. 2001. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51:2145-2165.
9. Ewing, S. A. 1969. Canine ehrlichiosis. Adv. Vet. Sci. Comp. Med. 13:331-353.
10. Harrus, S., M. Kenny, L. Miara, I. Aizenberg, T. Waner, and S. Shaw. 2004. Comparison of simultaneous splenic sample PCR with blood sample PCR for diagnosis and treatment of experimental Ehrlichia canis infection. Antimicrob. Agents Chemother. 48:4488-4490.
11. Harrus, S., T. Waner, I. Aizenberg, and H. Bark. 1998. Therapeutic effect of doxycycline in experimental subclinical canine monocytic ehrlichiosis: evaluation of a 6-week course. J. Clin. Microbiol. 36:2140-2142.
12. Harrus, S., T. Waner, I. Aizenberg, J. E. Foley, A. M. Poland, and H. Bark. 1998. Amplification of ehrlichial DNA from dogs 34 months after infection with Ehrlichia canis. J. Clin. Microbiol. 36:73-76.
13. Harrus, S., T. Waner, H. Bark, F. Jongejan, and A. W. Cornelissen. 1999. Recent advances in determining the pathogenesis of canine monocytic ehrlichiosis. J. Clin. Microbiol. 37:2745-2749.
14. Iqbal, Z., and Y. Rikihisa. 1994. Reisolation of Ehrlichia canis from blood and tissues of dogs after doxycycline treatment. J. Clin. Microbiol. 32:1644-1649.
15. Lewis, G. E., Jr., M. Ristic, R. D. Smith, T. Lincoln, and E. H. Stephenson. 1977. The brown dog tick Rhipicephalus sanguineus and the dog as experimental hosts of Ehrlichia canis. Am. J. Vet. Res. 38:1953-1955.
16. Neer, T. M., and S. Harrus. 2006. Canine monocytotropic ehrlichiosis and neorickettsiosis (E. canis, E. chaffeensis, E. ruminantium, N. sennetsu, and N. risticii infections), p. 203-216. In C. E. Greene (ed.), Infectious diseases of the dog and cat, 3rd ed. Saunders Elsevier, St. Louis, MO.
17. Ogunkoya, A. B., J. B. Adeyanju, and R. Abduhllahi. 1985. Experimental and clinical trials of long acting oxytetracycline in the treatment of canine ehrlichiosis. Vet. Q. 7:158-161.
18. Skotarczak, B. 2003. Canine ehrlichiosis. Ann. Agric. Environ. Med. 10:137-141.
19. Stich, R. W., Y. Rikihisa, S. A. Ewing, G. R. Needham, D. L. Grover, and S. Jittapalapong. 2002. Detection of Ehrlichia canis in canine carrier blood and in individual experimentally infected ticks with a p30-based PCR assay. J. Clin. Microbiol. 40:540-546.
20. Stich, R. W., J. J. Schaefer, W. G. Bremer, G. R. Needham, and S. Jittapalapong. Host surveys, ixodid tick biology and transmission scenarios as related to the tick-borne pathogen, Ehrlichia canis. Vet. Parasitol, in press.
21. Waner, T., S. Harrus, H. Bark, E. Bogin, Y. Avidar, and A. Keysary. 1997. Characterization of the subclinical phase of canine ehrlichiosis in experimentally infected beagle dogs. Vet. Parasitol. 69:307-317.
22. Wen, B., Y. Rikihisa, J. M. Mott, R. Greene, H. Y. Kim, N. Zhi, G. C. Couto, A. Unver, and R. Bartsch. 1997. Comparison of nested PCR with immuno-fluorescent-antibody assay for detection of Ehrlichia canis infection in dogs treated with doxycycline. J. Clin. Microbiol. 35:1852-1855.
23. Woody, B. J., and J. D. Hoskins. 1991. Ehrlichial diseases of dogs. Vet. Clin. N. Am. Small Anim. Pract. 21:75-98.