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Rubin, M.1
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(a) Tomilov, Y. V.; Shapiro, E. A.; Protopopova, M. N.; Ioffe, A. I.; Dolgii, I. E.; Nefedov, O. M. Izv. Akad. Nauk SSSR, Ser. Khim. 1985, 631.
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For selected examples on biological activity of indolizines, see: (a) Hagishita, S.; Yamada, M.; Shirahase, K.; Okada, T.; Murakami, Y.; Ito, Y.; Matsuura, T.; Wada, M.; Kato, T.; Ueno, M.; Chikazawa, Y.; Yamada, K.; Ono, T.; Teshirogi, I.; Ohtani, M. J. Med. Chem. 1996, 39, 3636.
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0035812675
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For cyclopropanation with 2-pyridyl diazo compounds, see
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35948964940
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13 we observed very low levels of enantioselectivity in synthesis of 3-aryl-substituted cyclopropenes. However, selected examples indicate highly enantioselective cyclopropenation in a case of 3-carbomethoxy derivatives see Table 1
-
13 we observed very low levels of enantioselectivity in synthesis of 3-aryl-substituted cyclopropenes. However, selected examples indicate highly enantioselective cyclopropenation in a case of 3-carbomethoxy derivatives (see Table 1).
-
-
-
-
35
-
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35948985643
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The C-2 site of indolizine is unfunctionalizable position and a substituent must be introduced prior to cyclization see ref 15
-
The C-2 site of indolizine is unfunctionalizable position and a substituent must be introduced prior to cyclization (see ref 15).
-
-
-
-
36
-
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35948931906
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For a review, see: (a) Behnisch, R.; Behnisch, P.; Eggenweiler, M.; Wallenhorst, T. In Houben-Weyl; Kreher, R. P., Ed.; Georg Thieme Verlag Stuttgart: New York, 1994; E6a/2a, pp 323-451.
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For a review, see: (a) Behnisch, R.; Behnisch, P.; Eggenweiler, M.; Wallenhorst, T. In Houben-Weyl; Kreher, R. P., Ed.; Georg Thieme Verlag Stuttgart: New York, 1994; Vol.E6a/2a, pp 323-451.
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34547510627
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For recent review on gold catalysis, see
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For recent review on gold catalysis, see: Hashmi, A. S. K. Chem. Rev. 2007, 107, 3180.
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Hashmi, A.S.K.1
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39
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35948970321
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Substrates, possessing alkyl substituents at C-1 position of cyclopropene ring produced only trace amounts of products under these reaction conditions.
-
Substrates, possessing alkyl substituents at C-1 position of cyclopropene ring produced only trace amounts of products under these reaction conditions.
-
-
-
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40
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35948963374
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For the synthesis of oxazolyl diazo compound, see ref 11
-
For the synthesis of oxazolyl diazo compound, see ref 11.
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-
-
-
41
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35948946635
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Prepared via cyclopropenation of corresponding triazoloisoquinoline analogously to pyridyl derivatives 3a-o see the Supporting Information for details
-
Prepared via cyclopropenation of corresponding triazoloisoquinoline analogously to pyridyl derivatives 3a-o (see the Supporting Information for details).
-
-
-
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42
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0001371890
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Hoye, T. R.; Dinsmore, C. J.; Johnson, D. S.; Korkowski, P. F. J. Org. Chem. 1990, 55, 4518.
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43
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35948938138
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Heterocyclic halides may be further functionalized via cross-coupling reactions.22 We have also shown (see ref 10) that halogen can be efficiently removed from the products
-
22 We have also shown (see ref 10) that halogen can be efficiently removed from the products.
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44
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0037112673
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For a review, see
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For a review, see: Littke, A. F.; Fu, G. C. Angew. Chem., Int. Ed. 2002, 41, 4176.
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Littke, A.F.1
Fu, G.C.2
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45
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35948943572
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Halogen-free 3-(2-pyridyl)cyclopropenes were not examined in the described rearrangements as they were not available via cyclopropenation of pyridotriazoles see ref 10
-
Halogen-free 3-(2-pyridyl)cyclopropenes were not examined in the described rearrangements as they were not available via cyclopropenation of pyridotriazoles (see ref 10).
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