Long-term treatment with the combination of amantadine and ribavirin in hepatitis C nonresponders. A case series

Digestive Diseases and Sciences

Volumn 52, Issue 12, 2007, Pages 3418-3422

  Riley III, Thomas R ^a,b   Taheri, Mohammad R ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b MC H045 ^*  (United States)

Author keywords

Amantadine; Hepatitis C; Nonresponder; Ribavirin; Treatment

Indexed keywords

ALANINE AMINOTRANSFERASE; AMANTADINE; RIBAVIRIN; TRAZODONE;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; HEPATITIS C; HUMAN; INSOMNIA; LIVER BIOPSY; LIVER CIRRHOSIS; LONG TERM CARE; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT RESPONSE; VIRUS LOAD;

AMANTADINE; ANTIVIRAL AGENTS; BIOPSY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; DRUG TOLERANCE; FEMALE; FOLLOW-UP STUDIES; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; MALE; MIDDLE AGED; RIBAVIRIN; RNA, VIRAL; TIME FACTORS; VIRAL LOAD;

EID: 35948961516     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9762-z     Document Type: Article

References (15)

1. Shepard CW, Finelli L, Alter MJ (2005) Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 5:558-567
2. Alter MJ, Margolis HS, Krawczynski K, et al (1992) The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team. N Engl J Med 327:1899-1905
3. McHutchison JG, Gordon SC, Schiff ER, Shiffman ML, Lee WM, Rustgi VK, Goodman ZD, Ling MH, Cort S, Albrecht JK (1998) Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med 339:1485-1492
4. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M, Albrecht JK (2001) Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomized trial. Lancet 358:958-965
5. Zeuzem S, Feinman SV, Rasenack J, Heathcote EJ, Lai MY, Gane E, O'Grady J, Reichen J, Diago M, Lin A, Hoffman J, Brunda MJ (2000) Peginterferon alfa-2a in patients with chronic hepatitis C. N Engl J Med 343:1723-1724
6. Fontana RJ (2004) Nonresponders to hepatitis C virus antiviral therapy: pegylated interferons and beyond. Gastroenterol Clin North Am 33:527-547
7. Ahmed F, Jacobson IM (2004) Treatment of relapsers after combination therapy for chronic hepatitis C. Gastroenterol Clin North Am 33:513-526
8. McHutchison JG, Dev AT (2004) Future trends in managing hepatitis C. Gastroenterol Clin North Am 33:S51-S61
9. Chan J, O'Riordan K, Wiley TE (2002) Amantadine's viral kinetics in chronic hepatitis C infection. Dig Dis Sci 47:438-442
10. Smith JP, Riley TR 3rd, Bingaman S, Mauger DT (2004) Amantadine therapy for chronic hepatitis C: a dose escalation study. Am J Gastroenterol 99:1099-1104
11. Smith JP (1997) Treatment of chronic hepatitis C with amantadine. Dig Dis Sci 42:1681-1687
12. Smith JP, Riley TR 3rd, Devenyi A, Bingaman SI, Kunselman A (2004) Amantadine therapy for chronic hepatitis C. J Gen Intern Med 19:662-668
13. Veldt BJ, Brouwer JT, Adler M, Nevens F, Michielsen P, Delwaide J, Hansen BE, Schalm SW, Benelux Study Group on Treatment of Chronic Hepatitis C (2003) Retreatment of hepatitis C non-responsive to interferon. A placebo controlled randomized trial of ribavirin monotherapy versus combination therapy with ribavirin and interferon in 121 patients in the Benelux. BMC Gastroenterol 3:24 [online]
14. Bodenheimer HC, Lindsay KL, Davis GL, Lewis JH, Thung SN, Seeff LB (1997) Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: a multicenter trial. Hepatology 26:473-477
15. Mathew A, Birkhotz J, Vidhyarthi J, Smith JP, Taheri MR, Riley TR (2007) Combination therapy with oral amantadine-HCl and ribavirin for chronic hepatitis C in non-interferon candidates (in press)