Metabolic acidosis as an underlying mechanism of respiratory distress in children with severe acute asthma

Pediatric Critical Care Medicine

Volumn 8, Issue 6, 2007, Pages 519-523

  Meert, Kathleen L ^a   Clark, Jeff ^a   Sarnaik, Ashok P ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acidosis; Adolescent; Adrenergic agonists; Asthma; Child; Critical care; Hyperventilation; Infant; Preschool

Indexed keywords

ADRENALIN; AMINOPHYLLINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DEXAMETHASONE; FLUTICASONE PROPIONATE PLUS SALMETEROL; GLUCOCORTICOID; INSULIN; IPRATROPIUM BROMIDE; MAGNESIUM SULFATE; PREDNISONE; SALBUTAMOL; TERBUTALINE; THEOPHYLLINE;

ADOLESCENT; AIRWAY OBSTRUCTION; ARTICLE; ARTIFICIAL VENTILATION; ASTHMA; CHILD; CLINICAL FEATURE; CONTINUOUS INFUSION; DISEASE SEVERITY; DRUG WITHDRAWAL; FEMALE; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; HYPERGLYCEMIA; HYPERVENTILATION; INFANT; INTENSIVE CARE UNIT; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; METABOLIC ACIDOSIS; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RESPIRATORY DISTRESS;

EID: 35948957826     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PCC.0000288673.82916.9D     Document Type: Article

References (32)

1. National Asthma Education and Prevention Program: Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma (NIH Publication No. 97-4051). Bethesda, MD, National Institutes of Health, 1997
2. Shapiro BA, Peruzzi WT, Templin R: Clinical Application of Blood Gases. Fifth Edition. St. Louis, MO, Mosby, 1994
3. Lumb AB: Nunn's Applied Respiratory Physiology. Sixth Edition. Philadelphia, Elsevier, 2006
4. Alberts WM, Williams JH, Ramsdell JW: Metabolic acidosis as a presenting feature in acute asthma. Ann Allergy 1986; 57:107-109
5. Roncoroni AJ, Adrogue HJA, DeObrutsky CW, et al: Metabolic acidosis in status asthmaticus. Respiration 1976; 33:85-94
6. Appel D, Rubenstein R, Schrager K, et al: Lactic acidosis in severe asthma. Am J Med 1983; 75:580-584
7. Mountain RD, Heffner JE, Brackett NC, et al: Acid-base disturbances in acute asthma. Chest 1990; 98:651-655
8. 2 agonists. J Clin Pharm Ther 1992; 17: 155-164
9. Rodrigo GJ, Rodrigo C: Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma. Emerg Med J 2005; 22:404-408
10. Maury E, Loos V, Lepecq B, et al: A paradoxical effect of bronchodilators. Chest 1997; 111:1766-1167
11. Rabbat A, Laaban JP, Boussairi A, et al: Hyperlactatemia during acute severe asthma. Intensive Care Med 1998; 24:304-312
12. Manthous C: Lactic acidosis in status asthmaticus. Chest 2001; 119:1599-1602
13. Murphy FT, Manown TJ, Knutson SW, et al: Epinephrine-induced lactic acidosis in the setting of status asthmaticus. South Med J 1995; 88:577-579
14. Yousef E, McGeady SJ: Lactic acidosis and status asthmaticus: How common in pediatrics? Ann Allergy Asthma Immunol 2002; 89:585-588
15. Assadi FK: Therapy of acute bronchospasm complicated by lactic acidosis and hypokalemia. Clin Pediatr 1989; 28:258-260
16. National Center for Health Statistics. Clinical growth charts. http://www.cdc.gov/growthcharts. Accessed February 12, 2007
17. Pollack MM, Patel KM, Ruttimann UE: PRISM III: An updated Pediatric Risk of Mortality score. Crit Care Med 1996; 24:743-752
18. Siggaard-Andersen O, Wimberley PD, Fogh-Andersen N, et al: Measured and derived quantities with modern pH and blood gas equipment: Calculation algorithms with 54 equations. Scand J Clin Lab Invest 1988; 48(Suppl 189):7-15
19. Statistical Package for the Social Sciences, Version 13.0. Chicago, IL, SPSS, 2004
20. Sarnaik AP, Daphtary KM, Meert KL, et al: Pressure controlled ventilation in children with severe status asthmaticus. Pediatr Crit Care Med 2004; 5:133-138
21. Okrent DG, Tessler S, Twersky RA, et al: Metabolic acidosis not due to lactic acidosis in patients with severe acute asthma. Crit Care Med 1987; 15:1098-1101
22. Stratakos G, Kalomenidis J, Routsi C, et al: Transient lactic acidosis as a side effect of inhaled salbutamol. Chest 2002; 122:385-386
23. Olson MS: Bioenergetics and oxidative metabolism. In: Textbook of Biochemistry With Clinical Correlations. Third Edition. Devlin TM (Ed). New York, Wiley-Liss, 1992, pp 237-289
24. Koh YI, Choi IS: Lactic acidosis associated with the usual theophylline dose in a patient with asthma. Korean J Intern Med 2002; 17:147-149
25. Gmehlin U, Stenz R, Stoz F: Metabolic acidosis in the 32nd week of pregnancy-uncontrolled diabetes in pregnancy: Dehydration or sequela of tocolysis? Zentralbl Gynakol 1994; 116:706-710
26. Rodgers BD, Rodgers DE: Clinical variables associated with diabetic ketoacidosis in pregnancy. J Reprod Med 1991; 11:797-800
27. Tibaldi JM, Lorber DL, Nerenberg A: Diabetic ketoacidosis and insulin resistance with subcutaneous terbutaline infusion: A case report. Am J Obstet Gynecol 1990; 163:509-510
28. Charmandari E, Kino T, Chrousos GP: Glucocorticoids. In: Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice. Third Edition. Yaffe SJ, Aranda JV (Eds). Philadelphia, Lippincott Williams & Wilkins, 2005, pp 713-726
29. Prakash S, Mehta S: Lactic acidosis in asthma: Report of two cases and review of literature. Can Respir J 2002; 9:203-208
30. He JQ, Joos L, Sandford AJ: Recent developments in the genetics of asthma. Pharmacogenomics 2001; 2:329-339
31. Weiss ST, Litonjua AA, Lange C, et al: Overview of pharmacogenetics of asthma treatment. Pharmacogenomics J 2006; 6:311-326
32. Bhatnagar P, Guleria R, Kukreti R: Pharmacogenomics of beta2-agonist: Key focus on signaling pathways. Pharmacogenomics 2006; 7:919-919