Tagged fragment method for evolutionary structure-based de novo lead generation and optimization

Journal of Medicinal Chemistry

Volumn 50, Issue 22, 2007, Pages 5392-5402

  Liu, Qian ^a   Masek, Brian ^a   Smith, Karl ^a   Smith, Julian ^b  

^a TRIPOS INC   (United States)

^b Tripos Discovery Research Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38;

ALGORITHM; ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; COMPUTER AIDED DESIGN; COMPUTER PROGRAM; DRUG DESIGN; DRUG STRUCTURE; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MECHANICS; REACTION OPTIMIZATION;

ALGORITHMS; DRUG DESIGN; ENZYME INHIBITORS; LIGANDS; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SOFTWARE;

EID: 35848947985     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070750k     Document Type: Article

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