Novel small-molecule inhibitors of transmissible gastroenteritis virus

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 11, 2007, Pages 3924-3931

  Yang, Cheng Wei ^a   Yang, Yung Ning ^a   Liang, Po Huang ^c   Chen, Chi Min ^b   Chen, Wei Liang ^a   Chang, Hwan You ^d   Chao, Yu Sheng ^a   Lee, Shiow Ju ^e  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b ANIMAL TECHNOLOGY INSTITUTE TAIWAN   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^e Division of Biotechnology and Pharmaceutical Research   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

A 01652; A 040437; A 041369; A 05175; A 06725; A 09853; A 10059; A 11605; A 17394; A 33224; A 36638; A 38120; A 39949; A 40437; A 41369; A 41558; A 51818; A 51828; A 51849; A 51858; A 51894; ANTIBODY; ANTIVIRUS AGENT; BENZOTHIAZOLIUM DERIVATIVE; CASPASE 3; NUCLEOCAPSID PROTEIN; PROTEINASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL LINE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; RNA REPLICATION; SWINE; TRANSMISSIBLE GASTROENTERITIS VIRUS; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; BENZOTHIAZOLES; BLOTTING, WESTERN; CASPASE 3; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; MALE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SWINE; TRANSMISSIBLE GASTROENTERITIS VIRUS; VIRUS REPLICATION;

EID: 35848942777     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00408-07     Document Type: Article

References (26)

1. Almazán, F., J. M. Gonzalez, Z. Penzes, A. Izeta, E. Calvo, J. Plana-Duran, and L. Enjuanes. 2000. Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome. Proc. Natl. Acad. Sci. USA 97:5516-5521.
2. Anand, K., G. J. Palm, J. R. Mesters, S. G. Siddell, J. Ziebuhr, and R. Hilgenfeld. 2002. Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain. EMBO J. 21:3213-3224.
3. Bacha, U., J. Barrila, A. Velazquez-Campoy, S. A. Leavitt, and E. Freire. 2004. Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro. Biochemistry 43:4906-4912.
4. Banerjee, S., S. An, A. Zhou, R. H. Silverman, and S. Makino. 2000. RNase L-independent specific 28S rRNA cleavage in murine coronavirus-infected cells. J. Virol. 74:8793-8802.
5. Chen, C. J., and S. Makino. 2002. Murine coronavirus-induced apoptosis in 17C1-1 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and bid cleavage. Virology 302:321-332.
6. Chen, C. M., D. H. Pocock, and P. Britton. 1993. Genomic organisation of a virulent Taiwanese strain of transmissible gastroenteritis virus. Adv. Exp. Med. Biol. 342:23-28.
7. Chen, L., C. Gui, X. Luo, Q. Yang, S. Gunther, E. Scandella, C. Drosten, D. Bai, X. He, B. Ludewig, J. Chen, H. Luo, Y. Yang, Y. Yang, J. Zou, V. Thiel, K. Chen, J. Shen, X. Shen, and H. Jiang. 2005. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J. Virol. 79:7095-7103.
8. Eleouet, J. F., S. Chilmonczyk, L. Besnardeau, and H. Laude. 1998. Transmissible gastroenteritis coronavirus induces programmed cell death in infected cells through a caspase-dependent pathway. J. Virol. 72:4918-4924.
9. Fan, K., P. Wei, Q. Feng, S. Chen, C. Huang, L. Ma, B. Lai, J. Pei, Y. Liu, J. Chen, and L. Lai. 2004. Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase. J. Biol. Chem. 279:1637-1642.
10. Ganesh, V. K., N. Muller, K. Judge, C. H. Luan, R. Padmanabhan, and K. H. Murthy. 2005. Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases. Bioorg. Med. Chem. 13:257-264.
11. Hegyi, A., and J. Ziebuhr. 2002. Conservation of substrate specificities among coronavirus main proteases. J. Gen. Virol. 83:595-599.
12. Kuo, C. J., Y. H. Chi, J. T. Hsu, and P. H. Liang. 2004. Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate. Biochem. Biophys. Res. Commun. 318:862-867.
13. Liu, B., and J. Zhou. 2005. SARS-CoV protease inhibitors design using virtual screening method from natural products libraries. J. Comput. Chem. 26:484-490.
14. Liu, C., H. Y. Xu, and D. X. Liu. 2001. Induction of caspase-dependent apoptosis in cultured cells by the avian coronavirus infectious bronchitis virus. J. Virol. 75:6402-6409.
15. Liu, Y., Y. Cai, and X. Zhang. 2003. Induction of caspase-dependent apoptosis in cultured rat oligodendrocytes by murine coronavirus is mediated during cell entry and does not require virus replication. J. Virol. 77:11952-11963.
16. Mizutani, T., S. Fukushi, M. Saijo, I. Kurane, and S. Morikawa. 2004. Phosphorylation of p38 MAPK and its downstream targets in SARS coronavirus-infected cells. Biochem. Biophys. Res. Commun. 319:1228-1234.
17. Musial, B. L., J. K. Chojnacki, and C. I. Coleman. 2004. Atazanavir: a new protease inhibitor to treat HIV infection. Am. J. Health Syst. Pharm. 61:1365-1374.
18. Ni, Z. J., and A. S. Wagman. 2004. Progress and development of small molecule HCV antivirals. Curr. Opin. Drug Discov. Dev. 7:446-459.
19. Rajnarayanan, R. V., S. Dakshanamurthy, and N. Pattabiraman. 2004. "Teaching old drugs to kill new bugs": structure-based discovery of anti-SARS drugs. Biochem. Biophys. Res. Commun. 321:370-378.
20. Schwegmann-Wessels, C., and G. Herrler. 2006. Transmissible gastroenteritis virus infection: a vanishing specter. Dtsch. Tierarztl. Wochenschr. 113:157-159.
21. Wesley, R. D., and K. M. Lager. 2003. Increased litter survival rates, reduced clinical illness and better lactogenic immunity against TGEV in gilts that were primed as neonates with porcine respiratory coronavirus (PRCV). Vet. Microbiol. 95:175-186.
22. Witherell, G. 2000. AG-7088 Pfizer. Curr. Opin. Investig. Drugs 1:297-302.
23. Woods, R. D., and R. D. Wesley. 1992. Efficacy of antiserum produced in goats and pigs to passively protect piglets against virulent transmissible gastroenteritis virus. Can. J. Vet. Res. 56:170-172.
24. Wu, C. Y., J. T. Jan, S. H. Ma, C. J. Kuo, H. F. Juan, Y. S. Cheng, H. H. Hsu, H. C. Huang, D. Wu, A. Brik, F. S. Liang, R. S. Liu, J. M. Fang, S. T. Chen, P. H. Liang, and C. H. Wong. 2004. Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc. Natl. Acad. Sci. USA 101:10012-10017.
25. Xiong, B., C. S. Gui, X. Y. Xu, C. Luo, J. Chen, H. B. Luo, L. L. Chen, G. W. Li, T. Sun, C. Y. Yu, L. D. Yue, W. H. Duan, J. K. Shen, L. Qin, T. L. Shi, Y. X. Li, K. X. Chen, X. M. Luo, X. Shen, J. H. Shen, and H. L. Jiang. 2003. A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening. Acta Pharmacol. Sin. 24:497-504.
26. Yang, H., M. Yang, Y. Ding, Y. Liu, Z. Lou, Z. Zhou, L. Sun, L. Mo, S. Ye, H. Pang, G. F. Gao, K. Anand, M. Bartlam, R. Hilgenfeld, and Z. Rao. 2003. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc. Natl. Acad. Sci. USA 100:13190-13195.