Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects

Journal of Medicinal Chemistry

Volumn 50, Issue 22, 2007, Pages 5449-5456

  Ebdrup, Søren ^a   Refsgaard, Hanne Hoffmann Frølund ^a   Fledelius, Christian ^a   Jacobsen, Poul ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYMETHYLPIPERIDINE 1 CARBOXYLIC ACID 4 (5 TRIFLUOROMETHYLPYRIDIN 2 YLOXY)PHENYL ESTER; 4 HYDROXYPIPERIDINE 1 CARBOXYLIC ACID 4 (5 TRIFLUOROMETHYLPYRIDIN 2 YLOXY)PHENYL ESTER; CARBAMIC ACID; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; ERYTHROMYCIN; HORMONE SELECTIVE LIPASE INHIBITOR; HORMONE SENSITIVE LIPASE; PHENACETIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; DYSLIPIDEMIA; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; INSULIN RESISTANCE; LIPOLYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBAMATES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; GLYCEROL; ISOENZYMES; LIPOLYSIS; MALE; MICROSOMES, LIVER; PIPERIDINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; STEROL ESTERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35848941953     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0607653     Document Type: Article

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