Mitogenic signaling via platelet-derived growth factor β in metanephric mesenchymal cells

Journal of the American Society of Nephrology

Volumn 18, Issue 11, 2007, Pages 2903-2911

  Wagner, Brent ^a,c   Ricono, Jill M ^a,b   Gorin, Yves ^a   Block, Karen ^a   Arar, Mazen ^a   Riley, Dan ^a,b   Choudhury, Goutam Ghosh ^a,b   Abboud, Hanna E ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; BLASTEMA; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; MESENCHYME CELL; MITOGENESIS; MOUSE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 35848936524     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2006111229     Document Type: Article

References (39)

1. Betsholtz C, Lindblom P, Bjarnegard M, Enge M, Gerhardt H, Lindahl P: Role of platelet-derived growth factor in mesangium development and vasculopathies: Lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice. Curr Opin Nephrol Hypertens 13: 45-52, 2004
2. Heldin CH, Ostman A, Ronnstrand L: Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta 1378: F79-F113, 1998
3. Arar M, Xu YC, Elshihabi I, Barnes JL, Choudhury GG, Abboud HE: Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells. J Biol Chem 275; 9527-9533, 2000
4. Gorin Y, Ricono JM, Kim NH, Bhandari B, Choudhury GG, Abboud HE: Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Am J Physiol Renal Physiol 285: F219-F229, 2003
5. Lassegue B, Clempus RE: Vascular NAD(P)H oxidases: Specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol 285: R277-R297, 2003
6. Brandes RP, Kreuzer J: Vascular NADPH oxidases: Molecular mechanisms of activation. Cardiovasc Res 65: 16-27, 2005
7. Catarzi S, Biagioni C, Giannoni E, Favilli F, Marcucci T, Iantomasi T, Vincenzini MT: Redox regulation of platelet-derived-growth-factor-receptor: Role of NADPH-oxidase and c-Src tyrosine kinase. Biochim Biophys Acta 1745: 166-175, 2005
8. Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD: Homologs of gp91phox: Cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 269: 131-140, 2001
9. Soriano P: Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev 8: 1888-1896, 1994
10. Ricono JM, Xu YC, Arar M, Jin DC, Barnes JL, Abboud HE: Morphological insights into the origin of glomerular endothelial and mesangial cells and their precursors. J Histochem Cytochem 51: 141-150, 2003
11. Valius M, Kazlauskas A: Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 73: 321-334, 1993
12. Choudhury GG, Grandaliano G, Jin DC, Katz MS, Abboud HE: Activation of PLC and PI 3 kinase by PDGF receptor alpha is not sufficient for mitogenesis and migration in mesangial cells. Kidney Int 57: 908-917, 2000
13. Shiose A, Kuroda J, Tsuruya K, Hirai M, Hirakata H, Naito S, Hattori M, Sakaki Y, Sumimoto H: A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem 276: 1417-1423, 2001
14. Mahadev K, Motoshima H, Wu X, Ruddy JM, Arnold RS, Cheng G, Lambeth JD, Goldstein BJ: The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol 24: 1844-1854, 2004
15. Gorin Y, Block K, Hernandez J, Bhandari B, Wagner B, Barnes JL, Abboud HE: Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem 280: 39616-39626, 2005
16. Leveen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C: Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev 8: 1875-1887, 1994
17. Alpers CE, Seifert RA, Hudkins KL, Johnson RJ, Bowen-Pope DF: Developmental patterns of PDGF B-chain, PDGF-receptor, and alpha-actin expression in human glomerulogenesis. Kidney Int 42: 390-399, 1992
18. Ricono JM, Arar M, Choudhury GG, Abboud HE: Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells. Am J Physiol Renal Physiol 282: F211-F219, 2002
19. Klinghoffer RA, Mueting-Nelsen PF, Faerman A, Shani M, Soriano P: The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell 7: 343-354, 2001
20. Tallquist MD, Klinghoffer RA, Heuchel R, Mueting-Nelsen PF, Corrin PD, Heldin CH, Johnson RJ, Soriano P: Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3′-kinase and phospholipase Cgamma signaling pathways. Genes Dev 14: 3179-3190, 2000
21. English J, Pearson G, Wilsbacher J, Swantek J, Karandikar M, Xu S, Cobb M: New insights into the control of MAP kinase pathways. Exp Cell Res 253: 255-270, 1999
22. Jones SM, Kazlauskas A: Connecting signaling and cell cycle progression in growth factor-stimulated cells. Oncogene 19: 5558-5567, 2000
23. Choudhury GG, Karamitsos C, Hernandez J, Gentilini A, Bardgette J, Abboud HE: PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF. Am J Physiol 273: F931-F938, 1997
24. Heuchel R, Berg A, Tallquist M, Ahlen K, Reed RK, Rubin K, Claesson-Welsh L, Heldin CH, Soriano P: Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling. Proc Natl Acad Sci U S A 96: 11410-11415, 1999
25. Tallquist M, Kazlauskas A: PDGF signaling in cells and mice. Cytokine Growth Factor Rev 15: 205-213, 2004
26. Vantler M, Caglayan E, Zimmermann WH, Baumer AT, Rosenkranz S: Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells: Only phosphatidylinositol 3′-kinase is important. J Biol Chem 280: 14168-14176, 2005
27. Grammer TC, Blenis J: Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases. Oncogene 14: 1635-1642, 1997
28. Finlay GA, Thannickal VJ, Fanburg BL, Kwiatkowski DJ: Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberin. Cancer Res 65: 10881-10890, 2005
29. Lavigne MC, Malech HL, Holland SM, Leto TL: Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells. Circulation 104: 79-84, 2001
30. Rao GN, Berk BC: Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ Res 70: 593-599, 1992
31. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T: Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270: 296-299, 1995
32. Sundaresan M, Yu ZX, Ferrans VJ, Sulciner DJ, Gutkind JS, Irani K, Goldschmidt-Clermont PJ, Finkel T: Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem J 318: 379-382, 1996
33. Couser WG, Pippin JW, Shankland SJ: Complement (C5b-9) induces DNA synthesis in rat mesangial cells in vitro. Kidney Int 59: 905-912, 2001
34. Kwan J, Wang H, Munk S, Xia L, Goldberg HJ, Whiteside CI: In high glucose protein kinase C-zeta activation is required for mesangial cell generation of reactive oxygen species. Kidney Int 68: 2526-2541, 2005
35. Lassegue B, Sorescu D, Szocs K, Yin Q, Akers M, Zhang Y, Grant SL, Lambeth JD, Griendling KK: Novel gp91(phox) homologues in vascular smooth muscle cells: Nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res 88: 888-894, 2001
36. Pleskova M, Beck KF, Behrens MH, Huwiler A, Fichtlscherer B, Wingerter O, Brandes RP, Mulsch A, Pfeilschifter J: Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. FASEB J 20: 139-141, 2006
37. Gorin Y, Kim NH, Feliers D, Bhandari B, Choudhury GG, Abboud HE: Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox-dependent pathway and independent of phosphoinositide 3-kinase. FASEB J 15: 1909-1920, 2001
38. Colston JT, de la Rosa SD, Strader JR, Anderson MA, Freeman GL: H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts. FEBS Lett 579: 2533-2540, 2005
39. Gorin Y, Ricono JM, Wagner B, Kim NH, Bhandari B, Choudhury GG, Abboud HE: Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Biochem J 381: 231-239, 2004