Homologous recombination and the yKu70/80 complex exert opposite roles in resistance against the killer toxin from Pichia acaciae

DNA Repair

Volumn 6, Issue 12, 2007, Pages 1864-1875

  Klassen, Roland ^a   Krampe, Stefan ^a   Meinhardt, Friedhelm ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Histone H2A; Homologous recombination; Killer; Non homologous end joining

Indexed keywords

ANTIGEN; DOUBLE STRANDED DNA; HISTONE H2A; KU ANTIGEN; KU80 PROTEIN; RAD52 PROTEIN; RECQ HELICASE; TOXIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME; CONTROLLED STUDY; DNA STRAND BREAKAGE; FRAGMENTATION REACTION; GENE MUTATION; GENE REPLICATION; HOMOLOGOUS RECOMBINATION; HYPERSENSITIVITY; NONHUMAN; PICHIA; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANTIGENS, NUCLEAR; BASE SEQUENCE; DNA DAMAGE; DNA PRIMERS; DNA-BINDING PROTEINS; ELECTROPHORESIS, GEL, PULSED-FIELD; HISTONES; MYCOTOXINS; PHOSPHORYLATION; PICHIA; RECOMBINATION, GENETIC;

PICHIA ACACIAE; SACCHAROMYCES CEREVISIAE;

EID: 35748980247     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2007.07.010     Document Type: Article

References (51)

1. Klassen R., Teichert S., and Meinhardt F. Novel yeast killer toxins provoke S-phase arrest and DNA damage checkpoint activation. Mol. Microbiol. 53 (2004) 263-273
2. Klassen R., and Meinhardt F. Induction of DNA damage and apoptosis in Saccharomyces cerevisiae by a yeast killer toxin. Cell. Microbiol. 7 (2005) 393-401
3. Worsham P.L., and Bolen P.L. Killer toxin production in Pichia acaciae is associated with linear DNA plasmids. Curr. Genet. 18 (1990) 77-80
4. Bolen P.L., Eastman E.M., Cihak P.L., and Hayman G.T. Isolation and sequence analysis of a gene from the linear DNA plasmid pPacl-2 of Pichia acaciae that shows similarity to a killer toxin gene of Kluyveromyces lactis. Yeast 10 (1994) 403-414
5. McCracken D.A., Martin V.J., Stark M.J., and Bolen P.L. The linear-plasmid-encoded toxin produced by the yeast Pichia acaciae: characterization and comparison with the toxin of Kluyveromyces lactis. Microbiology 140 (1994) 425-431
6. Paluszynski J.P., Klassen R., and Meinhardt F. The Pichia acaciae killer system: Genetic analysis of toxin immunity. Appl. Environ. Microbiol. 73 (2007) 4373-4378
7. Santocanale C., and Diffley J.F. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395 (1998) 615-618
8. Lopes M., Cotta-Ramusino C., Pellicioli A., Liberi G., Plevani P., Muzi-Falconi M., Newlon C.S., and Foiani M. The DNA replication checkpoint response stabilizes stalled replication forks. Nature 412 (2001) 557-561
9. Gasch A.P., Huang M., Metzner S., Botstein D., Elledge S.L., and Brown P.O. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol. Biol. Cell 12 (2001) 2987-3003
10. Desany B.A., Alcasabas A.A., Bachant J.B., and Elledge S.J. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev. 12 (1998) 2956-2970
11. Tercero J.A., and Diffley J.F. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 412 (2001) 553-557
12. Reiter J., Herker E., Madeo F., and Schmitt M.J. Viral killer toxins induce caspase-mediated apoptosis in yeast. J. Cell. Biol. 168 (2005) 353-358
13. Klassen R., Jablonowski D., Stark M.J.R., Schaffrath R., and Meinhardt F. Mating type locus control of killer toxins from Kluyveromyces lactis and Pichia acaciae. FEMS Yeast Res. 6 (2006) 404-413
14. Gietz R.D., and Schiestl R.H. Transforming yeast with DNA. Methods Mol. Cell. Biol. 5 (1995) 255-269
15. Niedenthal R.K., Riles L., Johnston M., and Hegemann J.H. Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast. Yeast 12 (1996) 773-786
16. Gueldener U., Heinisch J., Koehler G.J., Voll D., and Hegemann J.H. A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast. Nucl. Acids Res. 30 (2002) e23
17. Downs J.A., Lowndes N.F., and Jackson S.P. A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 408 (2000) 1001-1004
18. Sambrook J., and Russell D.W. Molecular Cloning: A Laboratory Manual. third ed. (2001), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
19. Friis J., and Roman H. The effect of the mating-type alleles on intragenic recombination in yeast. Genetics 59 (1968) 33-36
20. Heude M., and Fabre F. a/alpha-control of DNA repair in the yeast Saccharomyces cerevisiae: genetic and physiological aspects. Genetics 133 (1993) 489-498
21. Clikeman J.A., Khalsa G.J., Barton S.L., and Nickoloff J.A. Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms. Genetics 157 (2001) 579-589
22. Valencia M., Bentele M., Vaze M.B., Herrmann G., Kraus E., Lee S.E., Schar P., and Haber J.E. NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae. Nature 414 (2001) 666-669
23. Pâques F., and Haber J.E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63 (1999) 349-404
24. Symington L.S. Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol. Mol. Biol. Rev. 66 (2002) 630-670
25. Krogh B.O., and Symington L.S. Recombination proteins in yeast. Annu. Rev. Genet. 38 (2004) 233-271
26. Astrom S.U., Okamura S.M., and Rine J. Yeast cell-type regulation of DNA repair. Nature 397 (1999) 310
27. Milne G.T., Jin S., Shannon K.B., and Weaver D.T. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 16 (1996) 4189-4198
28. Dudasova Z., Dudas A., and Chovanec M. Non-homologous end-joining factors of Saccharomyces cerevisiae. FEMS Microbiol. Rev. 28 (2004) 581-601
29. Daley J.M., Palmbos P.L., Wu D., and Wilson T.E. Nonhomologous end joining in yeast. Annu. Rev. Genet. 39 (2005) 431-451
30. Herrmann G., Lindahl T., and Schar P. Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4. EMBO J. 17 (1998) 4188-4198
31. Shroff R., Arbel-Eden A., Pilch D., Ira G., Bonner W.M., Petrini J.H., Haber J.E., and Lichten M. Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr. Biol. 14 (2004) 1703-1711
32. Lisby M., Rothstein R., and Mortensen U.H. Rad52 forms DNA repair and recombination centers during S phase. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 8276-8282
33. Lisby M., Mortensen U.H., and Rothstein R. Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre. Nat. Cell. Biol. 5 (2003) 572-577
34. Geigl E., and Eckardt-Schupp F. Chromosome-specific identification and quantification of S1 nuclease-sensitive sites in yeast chromatin by pulsed-field gel electrophoresis. Mol. Microbiol. 4 (1990) 801-810
35. Moore C.W., McKoy J., Dardalhon M., Davermann D., Martinez M., and Averbeck D. DNA damage-inducible and RAD52-independent repair of DNA double-strand breaks in Saccharomyces cerevisiae. Genetics 154 (2000) 1085-1099
36. Ramey C.J., Howar S., Adkins M., Linger J., Spicer J., and Tyler J.K. Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1. Mol. Cell. Biol. 24 (2004) 10313-10327
37. Green B.M., and Li J.J. Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage. Mol. Biol. Cell. 16 (2005) 421-432
38. Mullen J.R., Kaliraman V., Ibrahim S.S., and Brill S.J. Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics 157 (2001) 103-118
39. Kaliraman V., Mullen J.R., Fricke W.M., Bastin-Shanower S.A., and Brill S.J. Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev. 15 (2001) 2730-2740
40. Cobb J.A., and Bjergbaek L. RecQ helicases: lessons from model organisms. Nucleic Acids Res. 34 (2006) 4106-4114
41. Kaliraman V., and Brill S.J. Role of SGS1 and SLX4 in maintaining rDNA structure in Saccharomyces cerevisiae. Curr. Genet. 41 (2002) 389-400
42. Fricke W.M., and Brill S.J. Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Genes Dev. 17 (2003) 1768-1778
43. Symington L.S. Focus on recombinational DNA repair. EMBO Rep. 6 (2005) 512-517
44. Frei C., and Gasser S.M. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. Genes Dev. 14 (2000) 81-96
45. Cobb J.A., Bjergbaek L., Shimada K., Frei C., and Gasser S.M. DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J. 22 (2003) 4325-4336
46. Cobb J.A., Schleker T., Rojas V., Bjergbaek L., Tercero J.A., and Gasser S.M. Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. Genes Dev. 19 (2005) 3055-3069
47. Bjergbaek L., Cobb J.A., Tsai-Pflugfelder M., and Gasser S.M. Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance. EMBO J. 24 (2005) 405-417
48. Hsiang Y.H., Lihou M.G., and Liu L.F. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res. 49 (1989) 5077-5082
49. Deng C., Brown J.A., You D., and Brown J.M. Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae. Genetics 170 (2005) 591-600
50. Adachi N., So S., and Koyama H. Loss of nonhomologous end joining confers camptothecin resistance in DT40 cells. Implications for the repair of topoisomerase I-mediated DNA damage. J. Biol. Chem. 279 (2004) 37343-37348
51. Schürer K.A., Rudolph C., Ulrich H.D., and Kramer W. Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from homologous recombination, but not from postreplicative repair. Genetics 166 (2004) 1673-1686