Mycophenolate mofetil in lupus glomerulonephritis: Effectiveness and tolerability

Annals of the New York Academy of Sciences

Volumn 1110, Issue , 2007, Pages 516-524

  Iaccarino, Luca ^a   Arienti, Silvia ^a   Rampudda, Mariaelisa ^a   Canova, Mariagrazia ^a   Atzeni, Fabiola ^b   Sarzi Puttini, Piercarlo ^b   Doria, Andrea ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Immunosuppressants; Lupus nephritis; Mycophenolate mofetil; Prognosis; Secondary prevention; Systemic lupus erythematosus; Therapy

Indexed keywords

AZATHIOPRINE; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; PROTON PUMP INHIBITOR;

BLOATING; CLINICAL TRIAL; CONFERENCE PAPER; DIARRHEA; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG TOLERABILITY; HUMAN; INFECTION; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOMA; MUCOSA INFLAMMATION; NAUSEA; PROTEINURIA; VOMITING;

EID: 35748969116     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1423.055     Document Type: Conference Paper

References (40)

1. DORIA, A., L. IACCARINO, A. GHIRARDELLO, et al. 2006. Long-term prognosis and causes of death in systemic lupus erythematosus. Am. J. Med. 119: 700-706.
2. MELLER, S., B. HOMEY, T. RUZICKA. 2005. Socioeconomic factors in lupus erythematosus. Autoimmun. Rev. 4: 242-246.
3. SCHWARTZ, N., L. SU, L.C. BURKLY, et al. 2006. Urinary TWEAK and the activity of lupus nephritis. J. Autoimmun. 27: 242-250.
4. SEELEN, M.A. & M.R. DAHA. 2006. The role of complement in autoimmune renal disease. Autoimmunity 5: 411-415.
5. DESHMUKH, U.S., H. BAGAVANT & S.M. FU. 2006. Role of anti-DNA antibodies in the pathogenesis of lupus nephritis. Autoimmun. Rev. 5: 414-418.
6. LI, Y., M. TUCCI & S. NARAIN. 2006. Urinary biomarkers in lupus nephritis. Autoimmun. Rev. 5: 383-388.
7. MANGER, K., L. WILDT, J.R. KALDEN, et al. 2006. Prevention of gonadal toxicity and preservation of gonadal function and fertility in young women with systemic lupus erythematosus treated by cyclophosphamide: the PREGO-Study. Autoimmun. Rev. 5: 269-272.
8. IACCARINO, L., M. RAMPUDDA, M. CANOVA, et al. 2007. Mycophenolate mofetil: What is its place in the treatment of autoimmune rheumatic diseases? Autoimmun. Rev. 6: 190-195.
9. DOOLEY, M.A. 2006. Mycophenolate mofetil: what role in the treatment of lupus? Lupus 15: 179-182.
10. CHAN, T.M.F.K. Li, C. S. TANG, et al. 2000. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group. N. Engl. J. Med. 343: 1156-1162.
11. ONG, L.M., L.S. HOOI, T.O. LIM, et al. 2005. Randomized controlled trial of pulse intravenous cyclophosphamide versus mycophenolate mofetil in the induction therapy of proliferative lupus nephritis. Nephrology 10: 504-510.
12. GINZLER, E.M., M.A. DOOLEY, C. ARANOW, et al. 2005. Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. N. Engl. J. Med. 353: 2219-2228.
13. CONTRERAS, G., V. PARDO, B. LECLERCQ, et al. 2004. Sequential therapies for proliferative lupus nephritis. N. Engl. J. Med. 350: 971-980.
14. DOOLEY, M.A., F.G. COSIO, P.H. NACHMAN, et al. 1999. Mycophenolate mofetil therapy in lupus nephritis: clinical observations. J. Am. Soc. Nephrol. 10: 833-839.
15. LI, L., H. WANG, S. LIN, et al. 2002. Mycophenolate mofetil treatment for diffuse proliferative lupus nephritis: a multicenter clinical trial in China. Zhonghua. Nei. Ke. Za. Zhi. 41: 476-479.
16. KINGDON, E.J., A.G. MCLEAN, E. PSIMENOU, et al. 2001. The safety and efficacy of MMF in lupus nephritis: a pilot study. Lupus 10: 606-611.
17. DING, L., M. ZHAO, W. ZOU, et al. 2004. Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis: a histopathological study. Lupus 13: 113-118.
18. KAPITSINOU, P.P., J.N. BOLETIS, F.N. SKOPOULI, et al. 2004. Lupus nephritis: treatment with mycophenolate mofetil. Rheumatology 43: 377-380.
19. FERRO, M.L., M.Y. KARIM, I.C. ABBIS, et al. 2003. Mycophenolate mofetil: a potential treatment for reducing proteinuria associated with membranous lupus nephritis. Arthritis. Rheum. 48: S588.
20. BORBA, E.F., L.K. GUEDES, R.B. CHRISTMANN, et al. 2006. Mycophenolate mofetil is effective in reducing lupus glomerulonephritis proteinuria. Rheumatol. Int. 26: 1078-1083.
21. HU, W., Z. LIU, H., CHEN, et al. 2002. Mycophenolate mofetil vs cyclophosphamide therapy for patients with diffuse proliferative lupus nephritis. Chin. Med. J. 115: 705-709.
22. FALK, R.J. 2000. Treatment of lupus nephritis: a work in progress. New. Engl. J. Med. 343: 1182-1183.
23. CHAN, T.M., W.S. WONG, C.S. LAU, et al. 2001. Follow-up of patients with diffuse proliferative lupus nephritis treated with prednisolone and mycophenolate mofetil [abstract]. J. Am. Soc. Nephrol. 12: 195A.
24. CHAN, T.M., K.C. TSE, C.S. TANG, et al. 2005. Long term study of mycophenolate mofetil as continuous induction and manteinance treatment for diffuse proliferative lupus nephritis. J. Am. Soc. Nephrol. 16: 1076-1084.
25. BOUMPAS, D.T., H.A. III Austin, E.M. VAUGHN, et al. 1992. Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis. Lancet 340: 741-45.
26. ILLEI, G.G., H.A. AUSTIN, M. CRANE, et al. 2001. Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis. Ann. Intern. Med. 135: 248-257.
27. ILLEI, G.G., K. TAKADA, D. PARKIN, et al. 2002. Renal flares are common in patients with severe proliferative lupus nephritis treated with pulse immunosuppressive therapy. Long-term follow-up of a cohort of 145 patients participating in randomized controlled trials. Arthritis. Rheum. 46: 995-1002.
28. GOURLEY, M.F., H.A. III AUSTIN, D. SCOTT, et al. 1996. Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. A randomized, controlled trial. Ann. Intern. Med. 125: 549-557.
29. DORIA, A., L. IACCARINO, S. ARIENTI, et al. 2006. Mycophenolate mofetil and systemic lupus erythematosus. Lupus 15(Suppl.): 44-54.
30. PISONI, C.N., F.J. SANCHEZ, Y. KARIM, et al. 2005. Mycophenolate mofetil in systemic lupus erythematosus: efficacy and tolerability in 86 patients. J. Rheumatol. 32: 1047-1052.
31. RISKALLA, M.M., E.C. SOMERS, R.A. FATICA, et al. 2003. Tolerability of mycophenalte mofetil in patients with systemic lupus erythematosus. J. Rheumatol. 30: 1508-1512.
32. TSE, K.C., C.S.O. TANG, W.I. LIO, et al. 2006. Quality of life comparison between corticosteroid-and- mycophenolate mofetil and corticosteroid-and-oral cyclophosphamide in the treatment of severe lupus nephritis. Lupus. 15: 371-379.
33. OPELZ, G. & B. DOHLER. 2004. Lymphomas after solid organ transplantation: a collaborative transplant study report. Am. J. Transplant. 4: 222-230.
34. BERNATSKY, S., R. RAMSEY-GOLDMAN, R. RAJAN, et al. 2005. Non-Hodgkin's lymphoma in systemic lupus erythematosus. Ann. Rheum. Dis. 64: 1507-1509.
35. THE TRICONTINENTAL MYCOPHENOLATE MOFETIL RENAL TRANSPLANTATION STUDY GROUP. 1996. A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplant. Transplantation 61: 1029-1037.
36. ROBSON, R., J.M. CECKA, G. OPELZ, et al. 2005. Prospective registry-based observational study of the long-term risk of malignancies in renal transplant patients treated with mycophenolate mofetil. Am. J. Transpl. 5: 2954-2960.
37. U.S. RENAL TRANSPLANT MYCOPHENOLATE MOFETIL STUDY GROUP. 1999. Mycophenolate mofetil in cadaveric renal transplantation. Am. J. Kidney. Dis. 34: 296-303.
38. SNANOUDJ, R., A. DURRBACH, V. LEBLOND, et al. 2003. Primary brain lymphomas after kidney transplantation: presentation and outcome. Transplantation 76: 930-937.
39. DASGUPTA, N., A.C. GELBER, F. RACKE, et al. 2005. Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis. Lupus 14: 910-913.
40. FINELLI, P.F., K. NAIK, J.A. DIG IUSEPPE, et al. 2006. Primary lymphoma of CND, mycophenolate mofetil and lupus. Lupus 15: 886-888.