Injuries from needles contaminated with hepatitis C virus. How high is the risk of seroconversion for medical personnel really?;Verletzungen mit hepatitis-C-virus-kontaminierten nadeln. Wie hoch ist das risiko einer serokonversion bei medizinischem personal wirklich?

Internist

Volumn 48, Issue 10, 2007, Pages 1165-1172

  Kubitschke, A ^a   Bader, C ^a   Tillmann, H L ^b   Manns, M P ^a   Kuhn, S ^a   Wedemeyer, H ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Hepatitis C; Medical personnel; Needle injury; Seroconversion

Indexed keywords

ARTICLE; ASIA; CONTROLLED STUDY; EUROPE; FOLLOW UP; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MEDICAL PERSONNEL; MEDICAL SCHOOL; NEEDLESTICK INJURY; RISK FACTOR; SEROCONVERSION; VIRAL CONTAMINATION; VIREMIA;

CARRIER STATE; CROSS-CULTURAL COMPARISON; CROSS-SECTIONAL STUDIES; DISEASE TRANSMISSION, PATIENT-TO-PROFESSIONAL; EUROPE; FOLLOW-UP STUDIES; GENOME, VIRAL; HEPACIVIRUS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS C; HEPATITIS C ANTIBODIES; HUMANS; INCIDENCE; NEEDLESTICK INJURIES; OCCUPATIONAL DISEASES; POLYMERASE CHAIN REACTION; RISK ASSESSMENT;

EID: 35748968173     PISSN: 00209554     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00108-007-1912-z     Document Type: Article

References (59)

1. Manns MP, Wedemeyer H, Meyer S et al.; Kompetenznetz Hepatitis (2004) Diagnostik, Verlauf und Therapie der Hepatitis-B(-D)-Virusinfektion, der akuten und chronischen Hepatitis-C-Virusinfektion sowie der viralen Hepatitis bei Kindern und Jugendlichen - Ergebnisse einer evidenzbasierten Konsensuskonferenz der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten und des Kompetenznetz Hepatitis. Z Gastroenterol 42: 677-678
2. The Global Burden of Hepatitis C Working Group (2004) Global burden of disease (GBD) for hepatitis C. J Clin Pharmacol 44: 20-29
3. Arai Y, Noda K, Enomoto N et al. (1996) A prospective study of hepatitis C virus infection after needlestick accidents. Liver 16: 331-334
4. Baldo V, Floreani A, Dal Vecchio L et al. (2002) Occupational risk of blood-borne viruses in healthcare workers: a 5-year surveillance program. Infect Control Hosp Epidemiol 23: 325-327
5. Chung H, Kudo M, Kumada T et al. (2003) Risk of HCV transmission after needlestick injury, and the efficacy of short-duration interferon administration to prevent HCV transmission to medical personnel. J Gastroenterol 38: 877-879
6. De Carli G, Puro V, Ippolito G (2003) Risk of hepatitis C virus transmission following percutaneous exposure in healthcare workers. Infection 31 (Suppl 2): 22-27
7. Gurtler L (2002) [Hepatitis C in Germany. More than 5000 new infections annually]. MMW Fortschr Med 144: 26-28
8. Hamid SS, Farooqui B, Rizvi Q et al. (1999) Risk of transmission and features of hepatitis C after needlestick injuries. Infect Control Hosp Epidemiol 20: 63-64
9. Hasan F, Askar H, Al Khalidi J et al. (1999) Lack of transmission of hepatitis C virus following needlestick accidents. Hepatogastroenterology 46: 1678-1681
10. Hernandez ME, Bruguera M, Puyuelo T et al. (1992) Risk of needle-stick injuries in the transmission of hepatitis C virus in hospital personnel. J Hepatol 16: 56-58
11. Ippolito G, Puro V, Petrosillo N et al. (1999) Surveillance of occupational exposure to bloodborne pathogens in health care workers: the Italian national programme. Euro Surveill 4: 33-36
12. Jaeckel E, Cornberg M, Wedemeyer H et al. (2001) Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med 345: 1452-1457
13. Kim SK, Cornberg M, Wang XZ et al. (2005) Private specificities of CD8 T cell responses control patterns of heterologous immunity. J Exp Med 201: 523-533
14. Kiyosawa K, Sodeyama T, Tanaka E et al. (1991) Hepatitis C in hospital employees with needlestick injuries. Ann Intern Med 115: 367-369
15. Kosgeroglu N, Ayranci U, Vardareli E et al. (2004) Occupational exposure to hepatitis infection among Turkish nurses: frequency of needle exposure, sharps injuries and vaccination. Epidemiol Infect 132: 27-33
16. Kralj N (2002) Nadelstichverletzungen im Gesundheitsdienst: Vorkommen, Folgen und Vorbeugung. Zahnärztliche Mitteilungen 19: 34-36
17. Kubitschke A, Bahr MJ, Aslan N et al. (2007) Induction of hepatitis C virus (HCV)-specific T cells by needle stick injury in the absence of HCV-viraemia. Eur J Clin Invest 37: 54-64
18. Lanphear BP, Linnemann CC Jr, Cannon CG et al. (1994) Hepatitis C virus infection in healthcare workers: risk of exposure and infection. Infect Control Hosp Epidemiol 15: 745-750
19. Manns MP, Wedemeyer H, Cornberg M (2006) Treating viral hepatitis C: efficacy, side effects, and complications. Gut 55: 1350-1359
20. Marranconi F, Mecenero V, Pellizzer GP et al. (1992) HCV infection after accidental needlestick injury in health-care workers. Infection 20: 111
21. Mehta A, Rodrigues C, Ghag S et al. (2005) Needlestick injuries in a tertiary care centre in Mumbai, India. J Hosp Infect 60: 368-373
22. Meyer MF, Wedemeyer H, Monazahian M et al. (2006) Prevalence of hepatitis C in a German prison for young men in relation to country of birth. Epidemiol Infect 7:1-7
23. Mihaly I, Telegdy L, Ibranyi E et al. (2001) Prevalence, genotype distribution and outcome of hepatitis C infections among the employees of the Hungarian Central Hospital for infectious diseases. J Hosp Infect 49: 239-244
24. Mitsui T, Iwano K, Masuko K et al. (1992) Hepatitis C virus infection in medical personnel after needlestick accident. Hepatology 16: 1109-1114
25. Mitsui T, Iwano K, Suzuki S et al. (1989) Combined hepatitis B immune globulin and vaccine for postexposure prophylaxis of accidental hepatitis B virus infection in hemodialysis staff members: comparison with immune globulin without vaccine in historical controls. Hepatology 10: 324-327
26. Miyajima I, Sata M, Murashima S et al. (1997) Prevalence of hepatitis C antibodies in health care personnel. Kansenshogaku Zasshi 71: 103-107
27. Mizuno Y, Suzuki K, Mori M et al. (1997) Study of needlestick accidents and hepatitis C virus infection in healthcare workers by molecular evolutionary analysis. J Hosp Infect 35: 149-154
28. Moens G, Vranckx R, De Greef L et al. (2000) Prevalence of hepatitis C antibodies in a large sample of Belgian healthcare workers. Infect Control Hosp Epidemiol 21: 209-212
29. Mülder K (2005) Nadelstichverletzungen - Der bagatellisierte., Massenunfall". Dtsch Arztebl 102: 558-561
30. Nukaya H, Ohno T, Sakakibara K et al. (2007) Accidental exposure to HCV antibody-positive blood in hospital and pre-emptive one-shot interferon alpha-2b treatment. Hepatol Res 37: 179-185
31. Oh HS, Yi SE, Choe KW (2005) Epidemiological characteristics of occupational blood exposures of healthcare workers in a university hospital in South Korea for 10 years. J Hosp Infect 60: 269-275
32. Okamoto N, Mizokami M, Kano H et al. (1991) [Risk of hepatitis C virus infection by needlestick among medical employees]. Kansenshogaku Zasshi 65: 1470-1475
33. Post JJ, Pan Y, Freeman AJ et al. (2004) Clearance of hepatitis C viremia associated with cellular immunity in the absence of seroconversion in the hepatitis C incidence and transmission in prisons study cohort. J Infect Dis 189: 1846-1855
34. Potthoff A, Schueler A, Wedemeyer H et al. (2003) Epidemiologie der Vriushepatitis A, B und C. In: Selmair H, Manns MP (Hrsg) Virushepatitis als Berufskrankheit. ecomed, Landsberg, S 13-22
35. Proietti L, Malaponte G, Libra M et al. (2005) Analysis of hepatitis C virus infection among health-care workers: an observational study. Minerva Gastroenterol Dietol 51: 255-259
36. Puro V, Petrosillo N, Ippolito G (1995) Risk of hepatitis C seroconversion after occupational exposures in health care workers. Italian Study Group on Occupational Risk of HIV and Other Bloodborne Infections. Am J Infect Control 23: 273-277
37. Puro V, Petrosillo N, Ippolito G et al. (1995) Occupational hepatitis C virus infection in Italian health care workers. Italian Study Group on Occupational Risk of Bloodborne Infections. Am J Public Health 85: 1272-1275
38. Rehermann B, Nascimbeni M (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5: 215-229
39. Rehman K, Khan AA, Haider Z et al. (1996) Prevalence of seromarkers of HBV and HCV in health care personnel and apparently healthy blood donors. J Pak Med Assoc 46: 152-154
40. Santantonio T, Fasano M, Sinisi E et al. (2005) Efficacy of a 24-week course of PEG-interferon alpha-2b monotherapy in patients with acute hepatitis C after failure of spontaneous clearance. J Hepatol 42: 329-333
41. Schreier E, Höhne M (2001) Hepatitis C - Epidemiologie und Prävention. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz 44: 554-561
42. Seeff LB, Hoofnagle JH (2002) National Institutes of Health Consensus Development Conference: management of hepatitis C: 2002. Hepatology 36 (Suppl 1): S1-S2
43. Shata MT, Tricoche N, Perkus M et al. (2003) Exposure to low infective doses of HCV induces cellular immune responses without consistently detectable viremia or seroconversion in chimpanzees. Virology 314: 601-616
44. Shiao J, Guo L, McLaws ML (2002) Estimation of the risk of bloodborne pathogens to health care workers after a needlestick injury in Taiwan. Am J Infect Control 30: 15-20
45. Simmonds P, Bukh J, Combet C et al. (2005) Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology 42: 962-973
46. Sodeyama T, Kiyosawa K, Urushihara A et al. (1993) Detection of hepatitis C virus markers and hepatitis C virus genomic-RNA after needlestick accidents. Arch Intern Med 153: 1565-1572
47. Stellini R, Calzini AS, Gussago A et al. (1993) Low prevalence of anti-HCV antibodies in hospital workers. Eur J Epidemiol 9: 674-675
48. Sulkowski MS, Ray SC, Thomas DL (2002) Needlestick transmission of hepatitis C. JAMA 287: 2406-2413
49. Takagi H, Uehara M, Kakizaki S et al. (1998) Accidental transmission of HCV and treatment with interferon. J Gastroenterol Hepatol 13: 238-243
50. Thierfelder W, Hellenbrand W, Meisel H et al. (2001) Prevalence of markers for hepatitis A, B and C in the German population. Results of the German National Health Interview and Examination Survey 1998. Eur J Epidemiol 17: 429-435
51. Thomson M, Nascimbeni M, Havert MB et al. (2003) The clearance of hepatitis C virus infection in chimpanzees may not necessarily correlate with the appearance of acquired immunity. J Virol 77: 862-870
52. Tillmann HL, Heringlake S, Trautwein C et al. (1998) Antibodies against the GB virus C envelope 2 protein before liver transplantation protect against GB virus C de novo infection. Hepatology 28: 379-384
53. Urbani S, Amadei B, Fisicaro P et al. (2005) Heterologous T cell immunity in severe hepatitis C virus infection. J Exp Med 201: 675-680
54. Varma M, Mehta G (2000) Needle stick injuries among medical students. J Indian Med Assoc 98: 436-438
55. Wedemeyer H, Cornberg M, Manns MP (2003) Immunopathogenesis and therapy of hepatitis C. In: Gershwin ME, Vierling JM, Manns MP (Eds) Liver Immunology. Hanley & Belfus, Philadelphia, pp 223-248
56. Wedemeyer H, Mizukoshi E, Davis AR et al. (2001) Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells. J Virol 75: 11392-11400
57. Wiegand J, Buggisch P, Boecher W et al. (2006) Early monotherapy with pegylated interferon alpha-2b for acute hepatitis C infection: The HEP-NET acute-HCV-II study. Hepatology 43: 250-256
58. Yazdanpanah Y, De Carli G, Migueres B et al. (2005) Risk factors for hepatitis C virus transmission to health care workers after occupational exposure: a european case-control study. Clin Infect Dis 41: 1423-1430
59. Zeuzem S (2004) Standardtherapie der akuten und chronischen Hepatitis C. Z Gastroenterol 42: 714-720