Oral administration of Taurolidine ameliorates chronic DSS colitis in mice

Journal of Investigative Surgery

Volumn 20, Issue 5, 2007, Pages 273-282

  Chromik, Ansgar Michael ^a   Müller, Annette M ^b   Albrecht, Martin ^a   Rottmann, Sabrina ^a   Otte, Jan Michel ^a   Herdegen, Thomas ^c   Uhl, Waldemar ^a   Mittelkötter, Ulrich ^a  

^a ST JOSEF HOSPITAL   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

C57BL6 mice; Cytokines; Dextran sulfate sodium; Experimental colitis; Inflammatory bowel disease; Real time PCR; Taurolidin; Taurolin; TRD

Indexed keywords

CYCLOOXYGENASE 2; DEXTRAN SULFATE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TAUROLIDINE; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL TRANSLOCATION; CHRONIC DISEASE; COLITIS; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; HISTOPATHOLOGY; INTESTINE CRYPT; LONG TERM CARE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCORING SYSTEM; SURVIVAL; TOXICITY TESTING;

ADMINISTRATION, ORAL; ANIMALS; BACTERIAL TRANSLOCATION; COLITIS; COLON; CYCLOOXYGENASE 2; CYTOKINES; DEXTRAN SULFATE; FEMALE; INFLAMMATORY BOWEL DISEASES; LYMPH NODES; MICE; MICE, INBRED C57BL; TAURINE; THIADIAZINES;

EID: 35748964730     PISSN: 08941939     EISSN: 15210553     Source Type: Journal    
DOI: 10.1080/08941930701598784     Document Type: Article

References (40)

1. van Montfrans, C., Peppelenbosch, M., Velde, A A te and van Deventer, S. (2002) Inflammatory signal transduction in Crohn's disease and novel therapeutic approaches. Biochem Pharmacol, 64, pp. 789-795.
2. Rogler, G. (2004) Update in inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol, 20, pp. 311-317.
3. Allon, M. (2004) Dialysis catheter-related bacteremia: Treatment and prophylaxis. Am J Kidney Dis, 44, pp. 779-791.
4. Reith, H. B. (1997) [Therapy of peritonitis today. Surgical management and adjuvant therapy strategies]. Langenbecks Arch Chir, 382, p. S14.
5. Koldehoff, M. and Zakrzewski, J. L. (2004) Taurolidine is effective in the treatment of central venous catheter-related bloodstream infections in cancer patients. Int J Antimicrob Agents, 24, pp. 491-495.
6. Dofferhoff, A. S., Esselink, M. T., de Vries-Hospers, H. G., van Zanten, A., Bom, V. J., Weits, J. and Vellenga, E. (1993) The release of endotoxin from antibiotic-treated Escherichia coli and the production of tumour necrosis factor by human monocytes. J Antimicrob Chemother, 31, pp. 373-384.
7. Pfirrmann, R. W. and Leslie, G. B. (1979) The anti-endotoxin activity of taurolin in experimental animals. J Appl Bacteriol., 46, pp. 97-102.
8. Calabresi, P., Goulette, F. A. and Darnowski, J. W. (2001) Taurolidine: Cytotoxic and mechanistic evaluation of a novel antineoplastic agent. Cancer Res, 61, pp. 6816-6821.
9. Bedrosian, I., Sofia, R. D., Wolff, S. M. and Dinarello, C. A. (1991) Taurolidine, an analogue of the amino acid taurine, suppresses interleukin 1 and tumor necrosis factor synthesis in human peripheral blood mononuclear cells. Cytokine, 3, pp. 568-575.
10. Sendt, W., Mansouri, E., Schmitt-Graeff, A., Wolff-Vorbeck, G. and Schoffel, U. (2002) Influence of antiseptic agents on interleukin-8 release and transmigration of polymorphonuclear neutrophils in a human in vitro model of peritonitis. Surg Infect (Larchmt), 3, pp. 235-244.
11. Rosman, C., Westerveld, G. J., van Oeveren, W., Kooi, K. and Bleichrodt, R. P. (1996) Effect of intraperitoneal antimicrobials on the concentration of bacteria, endotoxin, and tumor necrosis factor in abdominal fluid and plasma in rats. Eur Surg Res, 28, pp. 351-360.
12. Rosman, C., Westerveld, G. J., Kooi, K. and Bleichrodt, R. P. (1999) Local treatment of generalised peritonitis in rats; Effects on bacteria, endotoxin and mortality. Eur J Surg, 165, pp. 1072-1079.
13. Watson, R. W., Redmond, H. P., Carthy, J Mc and Bouchier-Hayes, D. (1995) Taurolidine, an antilipopolysaccharide agent, has immunoregulatory properties that are mediated by the amino acid taurine. J Leukocyte Biol, 58, pp. 299-306.
14. Okayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y. and Nakaya, R. (1990) A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology, 98, pp. 694-702.
15. Strober, W., Fuss, I. J. and Blumberg, R. S. (2002) The immunology of mucosal models of inflammation. Annu Rev Immunol, 20, pp. 495-549.
16. Cooper, H. S., Murthy, S. N., Shah, R. S. and Sedergran, D. J. (1993) Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest., 69, pp. 238-249.
17. Murthy, S. N., Cooper, H. S., Shim, H., Shah, R. S., Ibrahim, S. A. and Sedergran, D. J. (1993) Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig Dis Sci., 38, pp. 1722-1734.
18. Gardiner, K. R., Anderson, N. H., McCaigue, M. D., Erwin, P. J., Halliday, M. I. and Rowlands, B. J. (1994) Enteral and parenteral anti-endotoxin treatment in experimental colitis. Hepatogastroenterology, 41, pp. 554-558.
19. Steinbach-Lebbin, C., Ganz, A. J., Chang, A. and Waser, P. G. (1982) [Pharmacokinetics of taurolin]. Arzneim Forschung, 32, pp. 1542-1546.
20. Shanahan, F. (2005) Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases I. Pathophysiological basis and prospects for probiotic therapy in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol, 288, p. G417.
21. Sartor, R. B. (2004) Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: Antibiotics, probiotics, and prebiotics. Gastroenterology, 126, pp. 1620-1633.
22. Ardizzone, S. and Porro, G Bianchi (2005) Biologic therapy for inflammatory bowel disease. Drugs, 65, pp. 2253-2286.
23. Melgar, S., Karlsson, A. and Michaelsson, E. (2005) Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: Correlation between symptoms and inflammation. Am J Physiol Gastrointest Liver Physiol, 288, p. G1328.
24. Chromik, A. M., Muller, A. M., Korner, J., Belyaev, O., Holland-Letz, T., Schmitz, F., Herdegen, T., Uhl, W. and Mittelkotter, U. (2007) Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice. J Invest Surg, 20, pp. 23-33.
25. Egger, B., Procaccino, F., Lakshmanan, J., Reinshagen, M., Hoffmann, P., Patel, A., Reuben, W., Gnanakkan, S., Liu, L., Barajas, L. and Eysselein, V. E. (1997) Mice lacking transforming growth factor alpha have an increased susceptibility to dextran sulfate-induced colitis. Gastroenterology, 113, pp. 825-832.
26. Schultz, M., Strauch, U. G., Linde, H. J., Watzl, S., Obermeier, F., Gottl, C., Dunger, N., Grunwald, N., Scholmerich, J. and Rath, H. C. (2004) Preventive effects of Escherichia coli strain Nissle 1917 on acute and chronic intestinal inflammation in two different murine models of colitis. Clin Diagn Lab Immunol, 11, pp. 372-378.
27. Osman, N., Adawi, D., Ahrne, S., Jeppsson, B. and Molin, G. (2004) Modulation of the effect of dextran sulfate sodium-induced acute colitis by the administration of different probiotic strains of Lactobacillus and Bifidobacterium. Dig Dis Sci., 49, pp. 320-327.
28. Osman, N., Adawi, D., Molin, G., Ahrne, S., Berggren, A. and Jeppsson, B. (2006) Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats. BMC Gastroenterol, 6, p. 31.
29. Sakuraba, H., Ishiguro, Y., Yamagata, K., Tagawa, Y., Iwakura, Y., Sekikawa, K., Munakata, A. and Nakane, A. (2004) Transforming growth factor-beta regulates susceptibility of epithelial apoptosis in murine model of colitis. Ann NY Acad Sci, 1029, pp. 382-384.
30. Okayama, M., Hayashi, S., Aoi, Y., Nishio, H., Kato, S. and Takeuchi, K. (2007) Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. Dig Dis Sci
31. Tsubouchi, R., Hayashi, S., Aoi, Y., Nishio, H., Terashima, S., Kato, S. and Takeuchi, K. (2006) Healing impairment effect of cyclooxygenase inhibitors on dextran sulfate sodium-induced colitis in rats. Digestion, 74, pp. 91-100.
32. Martin, A. R., Villegas, I. and de la Lastra, C Alarcon (2005) The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice. Inflamm Res, 54, pp. 145-151.
33. Jacobi, C. A., Menenakos, C. and Braumann, C. (2005) Taurolidine - A new drug with anti-tumor and anti-angiogenic effects. Anticancer Drugs, 16, pp. 917-921.
34. Mudter, J. and Neurath, M. F. (2003) Mucosal T cells: Mediators or guardians of inflammatory bowel disease?. Curr Opin Gastroenterol, 19, pp. 343-349.
35. Atreya, R., Mudter, J., Finotto, S., Mullberg, J., Jostock, T., Wirtz, S., Schutz, M., Bartsch, B., Holtmann, M., Becker, C., Strand, D., Czaja, J., Schlaak, J. F., Lehr, H. A., Autschbach, F., Schurmann, G., Nishimoto, N., Yoshizaki, K., Ito, H., Kishimoto, T., Galle, P. R., Rose-John, S. and Neurath, M. F. (2000) Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo. Nat Med, 6, pp. 583-588.
36. Kamada, N., Inoue, N., Hisamatsu, T., Okamoto, S., Matsuoka, K., Sato, T., Chinen, H., Hong, K. S., Yamada, T., Suzuki, Y., Suzuki, T., Watanabe, N., Tsuchimoto, K. and Hibi, T. (2005) Nonpathogenic Escherichia coli strain Nissle1917 prevents murine acute and chronic colitis. Inflamm Bowel Dis., 11, pp. 455-463.
37. Giulietti, A., Overbergh, L., Valckx, D., Decallonne, B., Bouillon, R. and Mathieu, C. (2001) An overview of real-time quantitative PCR: Applications to quantify cytokine gene expression. Methods, 25, pp. 386-401.
38. Arita, M., Yoshida, M., Hong, S., Tjonahen, E., Glickman, J. N., Petasis, N. A., Blumberg, R. S. and Serhan, C. N. (2005) Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci USA, 102, pp. 7671-7676.
39. Overbergh, L., Giulietti, A., Valckx, D., Decallonne, R., Bouillon, R. and Mathieu, C. (2003) The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J Biomol Tech, 14, pp. 33-43.
40. Obermeier, F., Dunger, N., Deml, L., Herfarth, H., Scholmerich, J. and Falk, W. (2002) CpG motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium-treated mice. Eur J Immunol, 32, pp. 2084-2092.