메뉴 건너뛰기




Volumn 58, Issue 3, 2007, Pages 303-309

Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas

Author keywords

p16; p53; Proliferation; Squamous cell carcinoma; VRK1

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; PROTEIN C JUN; PROTEIN P16; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; VACCINIA RELATED KINASE 1;

EID: 35748961431     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2007.06.023     Document Type: Article
Times cited : (36)

References (35)
  • 2
    • 0030711601 scopus 로고    scopus 로고
    • Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase
    • Nezu J., Oku A., Jones M.H., and Shimane M. Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase. Genomics 45 (1997) 327-331
    • (1997) Genomics , vol.45 , pp. 327-331
    • Nezu, J.1    Oku, A.2    Jones, M.H.3    Shimane, M.4
  • 3
    • 45749089997 scopus 로고    scopus 로고
    • Lazo PA, Vega FM, Sevilla A. Vaccinia-related kinase-1. Afcs Nature Molecule Page; 2005. doi:10.1038/:mp.a003025.003001.
  • 4
    • 0034721101 scopus 로고    scopus 로고
    • The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein
    • Lopez-Borges S., and Lazo P.A. The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein. Oncogene 19 (2000) 3656-3664
    • (2000) Oncogene , vol.19 , pp. 3656-3664
    • Lopez-Borges, S.1    Lazo, P.A.2
  • 5
    • 0036509445 scopus 로고    scopus 로고
    • Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1
    • Barcia R., Lopez-Borges S., Vega F.M., and Lazo P.A. Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1. Arch Biochem Biophys 399 (2002) 1-5
    • (2002) Arch Biochem Biophys , vol.399 , pp. 1-5
    • Barcia, R.1    Lopez-Borges, S.2    Vega, F.M.3    Lazo, P.A.4
  • 6
    • 0036407644 scopus 로고    scopus 로고
    • Molecular mechanism of the interaction between MDM2 and p53
    • Schon O., Friedler A., Bycroft M., Freund S., and Fersht A. Molecular mechanism of the interaction between MDM2 and p53. J Mol Biol 323 (2002) 491-501
    • (2002) J Mol Biol , vol.323 , pp. 491-501
    • Schon, O.1    Friedler, A.2    Bycroft, M.3    Freund, S.4    Fersht, A.5
  • 7
    • 0037057316 scopus 로고    scopus 로고
    • Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21
    • Jabbur J.R., Tabor A.D., Cheng X., Wang H., Uesugi M., Lozano G., and Zhang W. Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Oncogene 21 (2002) 7100-7113
    • (2002) Oncogene , vol.21 , pp. 7100-7113
    • Jabbur, J.R.1    Tabor, A.D.2    Cheng, X.3    Wang, H.4    Uesugi, M.5    Lozano, G.6    Zhang, W.7
  • 8
    • 8644244682 scopus 로고    scopus 로고
    • p53 Stabilization and accumulation induced by human vaccinia-related kinase 1
    • Vega F.M., Sevilla A., and Lazo P.A. p53 Stabilization and accumulation induced by human vaccinia-related kinase 1. Mol Cell Biol 24 (2004) 10366-10380
    • (2004) Mol Cell Biol , vol.24 , pp. 10366-10380
    • Vega, F.M.1    Sevilla, A.2    Lazo, P.A.3
  • 9
    • 0038356612 scopus 로고    scopus 로고
    • Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development
    • Vega F.M., Gonzalo P., Gaspar M.L., and Lazo P.A. Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. FEBS Lett 544 (2003) 176-180
    • (2003) FEBS Lett , vol.544 , pp. 176-180
    • Vega, F.M.1    Gonzalo, P.2    Gaspar, M.L.3    Lazo, P.A.4
  • 11
    • 0031971228 scopus 로고    scopus 로고
    • Multisite phosphorylation and the integration of stress signals at p53
    • Meek D.W. Multisite phosphorylation and the integration of stress signals at p53. Cell Signal 10 (1998) 159-166
    • (1998) Cell Signal , vol.10 , pp. 159-166
    • Meek, D.W.1
  • 12
    • 33745434781 scopus 로고    scopus 로고
    • p53 downregulates its activating vaccinia-related kinase 1 forming a new autoregulatory loop
    • Valbuena A., Vega F.M., Blanco S., and Lazo P.A. p53 downregulates its activating vaccinia-related kinase 1 forming a new autoregulatory loop. Mol Cell Biol 26 (2006) 4782-4793
    • (2006) Mol Cell Biol , vol.26 , pp. 4782-4793
    • Valbuena, A.1    Vega, F.M.2    Blanco, S.3    Lazo, P.A.4
  • 17
    • 0026737950 scopus 로고
    • Accumulation of p53 protein correlates with a poor prognosis in human lung cancer
    • Quinlan D.C., Davidson A.G., Summers C.L., Warden H.E., and Doshi H.M. Accumulation of p53 protein correlates with a poor prognosis in human lung cancer. Cancer Res 52 (1992) 4828-4831
    • (1992) Cancer Res , vol.52 , pp. 4828-4831
    • Quinlan, D.C.1    Davidson, A.G.2    Summers, C.L.3    Warden, H.E.4    Doshi, H.M.5
  • 19
    • 0032786446 scopus 로고    scopus 로고
    • Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance
    • Brambilla E., Moro D., Gazzeri S., and Brambilla C. Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance. J Pathol 188 (1999) 351-360
    • (1999) J Pathol , vol.188 , pp. 351-360
    • Brambilla, E.1    Moro, D.2    Gazzeri, S.3    Brambilla, C.4
  • 21
    • 1542379726 scopus 로고    scopus 로고
    • Characterization of three paralogous members of the mammalian vaccinia related kinase family
    • Nichols R.J., and Traktman P. Characterization of three paralogous members of the mammalian vaccinia related kinase family. J Biol Chem 279 (2004) 7934-7946
    • (2004) J Biol Chem , vol.279 , pp. 7934-7946
    • Nichols, R.J.1    Traktman, P.2
  • 22
    • 33646680749 scopus 로고    scopus 로고
    • The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines
    • Blanco S., Klimcakova L., Vega F.M., and Lazo P.A. The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines. FEBS J 273 (2006) 2487-2504
    • (2006) FEBS J , vol.273 , pp. 2487-2504
    • Blanco, S.1    Klimcakova, L.2    Vega, F.M.3    Lazo, P.A.4
  • 23
    • 0035135235 scopus 로고    scopus 로고
    • Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology
    • Hirsch F.R., Franklin W.A., Gazdar A.F., and Bunn Jr. P.A. Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology. Clin Cancer Res 7 (2001) 5-22
    • (2001) Clin Cancer Res , vol.7 , pp. 5-22
    • Hirsch, F.R.1    Franklin, W.A.2    Gazdar, A.F.3    Bunn Jr., P.A.4
  • 24
    • 0002866241 scopus 로고    scopus 로고
    • Colorectal tumors
    • Kinzler K.W., and Vogesltein B. (Eds), McGraw-Hill, New York
    • Kinzler K.W., and Vogesltein B. Colorectal tumors. In: Kinzler K.W., and Vogesltein B. (Eds). The genetic basis of human cancer (1998), McGraw-Hill, New York 565-587
    • (1998) The genetic basis of human cancer , pp. 565-587
    • Kinzler, K.W.1    Vogesltein, B.2
  • 25
    • 0025817813 scopus 로고
    • Maintenance of p53 alterations throughout breast cancer progression
    • Davidoff A.M., Kerns B.J., Iglehart J.D., and Marks J.R. Maintenance of p53 alterations throughout breast cancer progression. Cancer Res 51 (1991) 2605-2610
    • (1991) Cancer Res , vol.51 , pp. 2605-2610
    • Davidoff, A.M.1    Kerns, B.J.2    Iglehart, J.D.3    Marks, J.R.4
  • 26
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives C., and Hall P.A. The p53 pathway. J Pathol 187 (1999) 112-126
    • (1999) J Pathol , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 28
    • 0035810054 scopus 로고    scopus 로고
    • Regulation of the G2/M transition by p53
    • Taylor W.R., and Stark G.R. Regulation of the G2/M transition by p53. Oncogene 20 (2001) 1803-1815
    • (2001) Oncogene , vol.20 , pp. 1803-1815
    • Taylor, W.R.1    Stark, G.R.2
  • 29
    • 0036145018 scopus 로고    scopus 로고
    • Multiple roles of the tumor suppressor p53
    • Bargonetti J., and Manfredi J.J. Multiple roles of the tumor suppressor p53. Curr Opin Oncol 14 (2002) 86-91
    • (2002) Curr Opin Oncol , vol.14 , pp. 86-91
    • Bargonetti, J.1    Manfredi, J.J.2
  • 30
    • 5344259041 scopus 로고    scopus 로고
    • c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)
    • Sevilla A., Santos C.R., Barcia R., Vega F.M., and Lazo P.A. c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK). Oncogene 23 (2004) 8950-8958
    • (2004) Oncogene , vol.23 , pp. 8950-8958
    • Sevilla, A.1    Santos, C.R.2    Barcia, R.3    Vega, F.M.4    Lazo, P.A.5
  • 31
    • 3042639759 scopus 로고    scopus 로고
    • Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK
    • Sevilla A., Santos C.R., Vega F.M., and Lazo P.A. Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. J Biol Chem 279 (2004) 27458-27465
    • (2004) J Biol Chem , vol.279 , pp. 27458-27465
    • Sevilla, A.1    Santos, C.R.2    Vega, F.M.3    Lazo, P.A.4
  • 32
    • 33745450085 scopus 로고    scopus 로고
    • The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus
    • Nichols R.J., Wiebe M.S., and Traktman P. The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus. Mol Biol Cell 17 (2006) 2451-2464
    • (2006) Mol Biol Cell , vol.17 , pp. 2451-2464
    • Nichols, R.J.1    Wiebe, M.S.2    Traktman, P.3
  • 33
    • 0035487104 scopus 로고    scopus 로고
    • The INK4a/ARF network in tumour suppression
    • Sherr C.J. The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol 2 (2001) 731-737
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 731-737
    • Sherr, C.J.1
  • 34
    • 0242495787 scopus 로고    scopus 로고
    • Identification of target genes of the p16INK4A-pRB-E2F pathway
    • Vernell R., Helin K., and Muller H. Identification of target genes of the p16INK4A-pRB-E2F pathway. J Biol Chem 278 (2003) 46124-46137
    • (2003) J Biol Chem , vol.278 , pp. 46124-46137
    • Vernell, R.1    Helin, K.2    Muller, H.3
  • 35
    • 33748670457 scopus 로고    scopus 로고
    • The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
    • Christophorou M.A., Ringshausen I., Finch A.J., Swigart L.B., and Evan G.I. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 443 (2006) 214-217
    • (2006) Nature , vol.443 , pp. 214-217
    • Christophorou, M.A.1    Ringshausen, I.2    Finch, A.J.3    Swigart, L.B.4    Evan, G.I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.