Pharmacogenetic study of cholesteryl ester transfer protein gene and simvastatin treatment in hypercholesterolaemic subjects

Expert Opinion on Pharmacotherapy

Volumn 8, Issue 15, 2007, Pages 2459-2463

  Anagnostopoulou, Katherine ^a   Kolovou, Genovefa ^a   Kostakou, Peggy ^a   Mihas, Constantinos ^b   Mikhailidis, Dimitri ^c   Cokkinos, Dennis V ^a  

^a ONASSIS CARDIAC SURGERY CENTER   (Greece)

^b General Hospital of Kimi   (Greece)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Cholesteryl ester transfer protein; Genetic polymorphism; I405V; Simvastatin; TaqIB

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GREECE; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; PHARMACOGENETICS; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 35748960257     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.8.15.2459     Document Type: Article

References (18)

1. OKAMOTO H, YONEMORI F, WAKITANI K, MINOWA T, MAEDA K, SHINKAI H: A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits. Nature (2000) 406:203-207.
2. GUERIN M, LE GOFF W, LASSEL TS, VAN TOL A, STEINER G, CHAPMAN MJ: Atherogenic role of elevated CE transfer from HDL to VLDL (1) and dense LDL in Type 2 diabetes: impact of the degree of hypertriglyceridemia. Arterioscler. Thromb. Vasc. Biol. (2001) 21(2):282-288.
3. BARTER PJ, BREWER HB Jr, CHAPMAN MJ, HENNEKENS CH, RADER DJ, TALL AR: Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler. Thromb. Vasc. Biol. (2003) 23(2):160-167.
4. BOEKHOLDT SM, THOMPSON JF: Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease. J. Lipid Res. (2003) 44(6):1080-1093.
5. DRAYNA D, LAWN R: Multiple RFLPs at the human cholesteryl ester transfer protein (CETP) locus. Nucleic Acids Res. (1987) 15:4698.
6. KUIVENHOVEN JA, DE KNIJFF P, BOER JMA et al.: Heterogeneity at the CETP gene locus: influence on plasma CETP concentrations and HDL cholesterol levels. Arterioscler. Thromb. Vasc. Biol. (1997) 17:560-568.
7. ORDOVAS JM, CUPPLES LA, CORELLA D et al. Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. Arterioscler. Thromb. Vasc. Biol. (2000) 20(5):1323-1329.
8. SZAPARY PO, RADER DJ: The triglyceride-high-density lipoprotein axis: an important target of therapy? Am. Heart J. (2004) 148(2):211-221.
9. LIBEROPOULOS EN, DASKALOPOULOU SS, MIKHAILIDIS DP, WIERZBICKI AS, ELISAF MS: A review of the lipid-related effects of fluvastatin. Curr. Med. Res. Opin. (2005) 21(2):231-244.
10. KOLOVOU GD, FOSTINIS YP, BILIANOU HI, COKKINOS DV: Response of high-density lipoproteins to hypolipidemic drugs according to their initial level. Am. J. Cardiol. (1995) 75(4):293-295.
11. GRUNDY SM, CLEEMAN JI, MERZ CN et al.; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION; AMERICAN HEART ASSOCIATION: Implications of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines. Circulation (2004) 110(2):227-239.
12. KOLOVOU G, ANAGNOSTOPOULOU K, KOSTAKOU P et al.: Association between the taqib polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia. Clin. Chem. Lab. Med. (2007) (In Press).
13. GUDNASON V, KAKKO S, NICAUD V et al.: Cholesteryl ester transfer protein gene effect on CETP activity and plasma high-density lipoprotein in European populations. The EARS group. Eur. J. Clin. Invest. (1999) 29(2):116-128.
14. KUIVENHOVEN JA, JUKEMA JW, ZWINDERMAN AH et al.: The rote of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The regression growth evaluation statin study group. N. Engl. J. Med. (1998) 338(2):86-93.
15. MOHRSCHLADT MF, VAN DER SMAN-DE BEER F, HOFMAN MK, VAN DER KRABBEN M, WESTENDORP RG, SMELT AH: TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia. Eur. J. Hum. Genet. (2005) 13(7):877-882.
16. VAN VENROOIJ FV, STOLK RP, BANGA JD et al.; DALI STUDY GROUP: Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in Type 2 diabetes. Diabetes Care (2003) 26(4):1216-1223.
17. KOLOVOU GD, ANAGNOSTOPOULOU KK, KARYOFILLIS P et al.: Cholesteryl ester transfer protein gene polymorphisms and severity of coronary stenosis. Clin. Invest. Med. (2006) 29(1):14-19.
18. IZEM L, MORTON RE: Possible role for intracellular cholesteryl ester transfer protein in adipocyte lipid metabolism and storage. J. Biol. Chem. (2007) 282(30):21856-21865.